Analysis of chromosomal aberrations, sister chromatid exchanges and micronuclei among power linesmen with long-term exposure to 50-Hz electromagnetic fields

Chromosomal aberrations, sister chromatid exchanges (SCEs), replication indices and micronuclei in peripheral blood lymphocytes were analysed among 27 nonsmoking power linesmen with considerable long-term exposure to 50-Hz electromagnetic (EM) fields, and among 27 nonsmoking telephone lines-men serving as a reference group, pairwise matched with the exposed workers for age and geographical region. Blood samples from the two groups were collected, cultured and analysed in parallel. No differences between the groups were observed on analysis of SCEs, replication indices or micronuclei. However, the mean rate of lymphocytes with chromatid-type breaks was higher among the power linesmen (0.96% gaps excluded, 1.41% gaps included) than among the reference group (0.44% and 0.70%, respectively). The excess of aberrant cells was concentrated among those power linesmen who had smoked earlier in their life. Although the interpretation is somewhat complicatedy the confounding effect of previous smoking, these results suggest that exposure to 50-Hz EM fields is associated with a slight increase in chromatid breaks.

[1]  A. Ahlbom,et al.  Cancer morbidity among workers in the telecommunications industry. , 1985, British journal of industrial medicine.

[2]  N. Pearce,et al.  LEUKAEMIA IN ELECTRICAL WORKERS IN NEW ZEALAND , 1985, The Lancet.

[3]  A Ahlbom,et al.  Mortality experience of electrical engineers. , 1985, British journal of industrial medicine.

[4]  K. H. Mild,et al.  Chromosomal effects in lymphocytes of 400 kV-substation workers , 1988, Radiation and environmental biophysics.

[5]  S. Nordström,et al.  Reproductive hazards among workers at high voltage substations. , 1983, Bioelectromagnetics.

[6]  E. Pukkala,et al.  Incidence of leukaemia and brain tumours in Finnish workers exposed to ELF magnetic fields , 1990, International archives of occupational and environmental health.

[7]  S. Milham,et al.  Mortality from leukemia in workers exposed to electrical and magnetic fields. , 1982, The New England journal of medicine.

[8]  M M Cohen,et al.  Effect of low-level, 60-Hz electromagnetic fields on human lymphoid cells: I. Mitotic rate and chromosome breakage in human peripheral lymphocytes. , 1986, Bioelectromagnetics.

[9]  S. Nordström,et al.  Clastogenic effects in human lymphocytes of power frequency electric fields: In vivo and in vitro studies , 1984, Radiation and environmental biophysics.

[10]  M. Penttilä,et al.  Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster. , 1980, Toxicology letters.

[11]  W. Wright,et al.  LEUKAEMIA IN WORKERS EXPOSED TO ELECTRICAL AND MAGNETIC FIELDS , 1982, The Lancet.

[12]  M. Bender,et al.  Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. , 1988, Mutation research.

[13]  G R Howe,et al.  A follow-up study of a ten-percent sample of the Canadian labor force. I. Cancer mortality in males, 1965-73. , 1983, Journal of the National Cancer Institute.

[14]  MichelP. Coleman,et al.  LEUKAEMIA INCIDENCE IN ELECTRICAL WORKERS , 1983, The Lancet.

[15]  K. Husgafvel‐Pursiainen,et al.  Toluene-exposed workers and chromosome aberrations. , 1980, Journal of toxicology and environmental health.

[16]  M M Cohen,et al.  The effect of low-level 60-Hz electromagnetic fields on human lymphoid cells. II. Sister-chromatid exchanges in peripheral lymphocytes and lymphoblastoid cell lines. , 1986, Mutation research.

[17]  G. Obe,et al.  Effects of 50-hertz electromagnetic fields on proliferation and on chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens. , 1989, Mutation research.

[18]  R Hauf,et al.  Analysis of structural chromosome changes and SCE after occupational long-term exposure to electric and magnetic fields from 380 kV-systems , 1981, Radiation and environmental biophysics.

[19]  Samuel Milham,et al.  SILENT KEYS: LEUKAEMIA MORTALITY IN AMATEUR RADIO OPERATORS , 1985, The Lancet.

[20]  D A Savitz,et al.  Leukemia in occupational groups with presumed exposure to electrical and magnetic fields. , 1985, The New England journal of medicine.

[21]  J. M. García-Sagredo,et al.  Effect on SCE in Human chromosomes in vitro of low‐level pulsed magnetic field , 1990, Environmental and molecular mutagenesis.

[22]  B Knave,et al.  Cancer in the electric power industry. , 1986, British journal of industrial medicine.

[23]  A. Vistnes,et al.  Chromosome aberrations in lymphocytes of high-voltage laboratory cable splicers exposed to electromagnetic fields. , 1993, Scandinavian journal of work, environment & health.

[24]  M. Mcdowall,et al.  LEUKAEMIA MORTALITY IN ELECTRICAL WORKERS IN ENGLAND AND WALES , 1983, The Lancet.

[25]  Tore Tynes,et al.  Electromagnetic fields and male breast cancer , 1990, The Lancet.

[26]  P C Dischinger,et al.  Occupational exposure to electromagnetic fields and the occurrence of brain tumors. An analysis of possible associations. , 1985, Journal of occupational medicine. : official publication of the Industrial Medical Association.