The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy

[1]  T. Hyslop,et al.  Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. , 2010, Cancer research.

[2]  J. Manley,et al.  Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches , 2009, Nature Reviews Molecular Cell Biology.

[3]  A. Krainer,et al.  Cooperative-Binding and Splicing-Repressive Properties of hnRNP A1 , 2009, Molecular and Cellular Biology.

[4]  C. Beattie,et al.  Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? , 2009, Nature Reviews Neuroscience.

[5]  L. Gangwani,et al.  A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy , 2009, RNA biology.

[6]  C. Lorson,et al.  Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy. , 2009, Human molecular genetics.

[7]  S. Richard,et al.  Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis , 2009, Journal of Cell Biology.

[8]  S. Richard,et al.  An Adaptor Role for Cytoplasmic Sam68 in Modulating Src Activity during Cell Polarization , 2009, Molecular and Cellular Biology.

[9]  I-Fan Wang,et al.  TDP-43 Overexpression Enhances Exon 7 Inclusion during the Survival of Motor Neuron Pre-mRNA Splicing* , 2008, Journal of Biological Chemistry.

[10]  M. Ares,et al.  Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis , 2008, Molecular and Cellular Biology.

[11]  R. Lu,et al.  The RNA Binding Protein hnRNP Q Modulates the Utilization of Exon 7 in the Survival Motor Neuron 2 (SMN2) Gene , 2008, Molecular and Cellular Biology.

[12]  L. Tsai,et al.  Restoring Bcl-xL levels benefits a mouse model of spinal muscular atrophy , 2008, Neurobiology of Disease.

[13]  K. Lukong,et al.  Motor coordination defects in mice deficient for the Sam68 RNA-binding protein , 2008, Behavioural Brain Research.

[14]  Lili Wan,et al.  SMN Deficiency Causes Tissue-Specific Perturbations in the Repertoire of snRNAs and Widespread Defects in Splicing , 2008, Cell.

[15]  C. Robson,et al.  The RNA‐binding and adaptor protein Sam68 modulates signal‐dependent splicing and transcriptional activity of the androgen receptor , 2008, The Journal of pathology.

[16]  Y. Hua,et al.  Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice. , 2008, American journal of human genetics.

[17]  J. Manley,et al.  hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing. , 2007, Human molecular genetics.

[18]  Guey-Shin Wang,et al.  Splicing in disease: disruption of the splicing code and the decoding machinery , 2007, Nature Reviews Genetics.

[19]  Grazia Gallo,et al.  Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound , 2007, Journal of leukocyte biology.

[20]  C. Sette,et al.  The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells , 2007, Oncogene.

[21]  L. Pellizzoni.  Chaperoning ribonucleoprotein biogenesis in health and disease , 2007, EMBO reports.

[22]  C. Chalfant,et al.  The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x , 2007, The Journal of cell biology.

[23]  Brenda F Baker,et al.  Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon , 2007, PLoS biology.

[24]  M. Fenton,et al.  Cutting Edge: Differential Inhibition of TLR Signaling Pathways by Cell-Permeable Peptides Representing BB Loops of TLRs1 , 2007, The Journal of Immunology.

[25]  J. Manley,et al.  An intronic element contributes to splicing repression in spinal muscular atrophy , 2007, Proceedings of the National Academy of Sciences.

[26]  C. Lorson,et al.  Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[27]  J. Yong,et al.  The SMN complex: an assembly machine for RNPs. , 2006, Cold Spring Harbor symposia on quantitative biology.

[28]  Elisa de Stanchina,et al.  Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. , 2006, American journal of human genetics.

[29]  U. Monani.  Spinal Muscular Atrophy: A Deficiency in a Ubiquitous Protein; a Motor Neuron-Specific Disease , 2005, Neuron.

[30]  Michael R Green,et al.  Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. , 2005, Molecular cell.

[31]  Juan Valcárcel,et al.  Building specificity with nonspecific RNA-binding proteins , 2005, Nature Structural &Molecular Biology.

[32]  F. Clark,et al.  Understanding alternative splicing: towards a cellular code , 2005, Nature Reviews Molecular Cell Biology.

[33]  C. Sette,et al.  Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-κB* , 2005, Journal of Biological Chemistry.

[34]  D. Shalloway,et al.  Sam68 exerts separable effects on cell cycle progression and apoptosis , 2004, BMC Cell Biology.

[35]  K. Lukong,et al.  Sam68, the KH domain-containing superSTAR. , 2003, Biochimica et biophysica acta.

[36]  D. Black.  Mechanisms of alternative pre-messenger RNA splicing. , 2003, Annual review of biochemistry.

[37]  J. Venables,et al.  tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCγ1 and Sam68 , 2003, Oncogene.

[38]  J. Manley,et al.  A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy , 2003, Nature Genetics.

[39]  P. Herrlich,et al.  Signal-dependent regulation of splicing via phosphorylation of Sam68 , 2002, Nature.

[40]  A. Krainer,et al.  Listening to silence and understanding nonsense: exonic mutations that affect splicing , 2002, Nature Reviews Genetics.

[41]  A. Krainer,et al.  Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1 , 2002, Nature Genetics.

[42]  P. Herrlich,et al.  Heterogeneous Ribonucleoprotein A1 Is Part of an Exon-specific Splice-silencing Complex Controlled by Oncogenic Signaling Pathways* , 2000, The Journal of Biological Chemistry.

[43]  S. Stamm,et al.  Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2). , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[44]  U. Monani,et al.  The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy. , 2000, Human molecular genetics.

[45]  S. Stamm,et al.  Htra 2-b 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 ( SMN 2 ) , 2000 .

[46]  J. McPherson,et al.  A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2. , 1999, Human molecular genetics.

[47]  C. Lorson,et al.  A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[48]  D. Shalloway,et al.  Specificity and Determinants of Sam68 RNA Binding , 1997, The Journal of Biological Chemistry.

[49]  S. Richard,et al.  Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain , 1997, Molecular and cellular biology.

[50]  Arnold Munnich,et al.  Correlation between severity and SMN protein level in spinal muscular atrophy , 1997, Nature Genetics.

[51]  Y. Kawasaki,et al.  Identification of a novel nuclear localization signal in Sam68 , 1997, FEBS letters.

[52]  A. Aiyar,et al.  Site-directed mutagenesis using overlap extension PCR. , 1996, Methods in molecular biology.

[53]  S. Richard,et al.  p62 Association with RNA Is Regulated by Tyrosine Phosphorylation (*) , 1995, The Journal of Biological Chemistry.

[54]  E. Taylor,et al.  Cell Motility , 1986, Journal of Cell Science.

[55]  J. Pearn.  CLASSIFICATION OF SPINAL MUSCULAR ATROPHIES , 1980, The Lancet.

[56]  M. Bjørneboe,et al.  KUPFFER CELLS AND CIRRHOSIS , 1975, The Lancet.