Angular signal radiography.

Microscopy techniques using visible photons, x-rays, neutrons, and electrons have made remarkable impact in many scientific disciplines. The microscopic data can often be expressed as the convolution of the spatial distribution of certain properties of the specimens and the inherent response function of the imaging system. The x-ray grating interferometer (XGI), which is sensitive to the deviation angle of the incoming x-rays, has attracted significant attention in the past years due to its capability in achieving x-ray phase contrast imaging with low brilliance source. However, the comprehensive and analytical theoretical framework is yet to be presented. Herein, we propose a theoretical framework termed angular signal radiography (ASR) to describe the imaging process of the XGI system in a classical, comprehensive and analytical manner. We demonstrated, by means of theoretical deduction and synchrotron based experiments, that the spatial distribution of specimens' physical properties, including absorption, refraction and scattering, can be extracted by ASR in XGI. Implementation of ASR in XGI offers advantages such as simplified phase retrieval algorithm, reduced overall radiation dose, and improved image acquisition speed. These advantages, as well as the limitations of the proposed method, are systematically investigated in this paper.

[1]  R Bellotti,et al.  Imaging the ultrasmall-angle x-ray scattering distribution with grating interferometry. , 2012, Physical review letters.

[2]  Atsushi Momose,et al.  Four-dimensional X-ray phase tomography with Talbot interferometry and white synchrotron radiation: dynamic observation of a living worm. , 2011, Optics express.

[3]  Han Wen,et al.  Fourier X-ray scattering radiography yields bone structural information. , 2009, Radiology.

[4]  Kejun Kang,et al.  Quantitative grating-based x-ray dark-field computed tomography , 2009 .

[5]  Ziyu Wu,et al.  Single-shot x-ray phase imaging with grating interferometry and photon-counting detectors. , 2014, Optics letters.

[6]  O. Bunk,et al.  Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources , 2006 .

[7]  M. Wernick,et al.  A physical model of multiple-image radiography , 2006, Physics in medicine and biology.

[8]  Yakov I Nesterets,et al.  Some simple rules for contrast, signal-to-noise and resolution in in-line x-ray phase-contrast imaging. , 2008, Optics express.

[9]  Han Wen,et al.  Motionless phase stepping in X-ray phase contrast imaging with a compact source , 2013, Proceedings of the National Academy of Sciences.

[10]  Piero Pianetta,et al.  Recent advances in synchrotron-based hard x-ray phase contrast imaging , 2013 .

[11]  Franz Pfeiffer,et al.  Grating-based X-ray phase contrast for biomedical imaging applications. , 2013, Zeitschrift fur medizinische Physik.

[12]  Li Zhang,et al.  Low-dose multiple-information retrieval algorithm for X-ray grating-based imaging , 2011 .

[13]  Ziyu Wu,et al.  Low-dose, simple, and fast grating-based X-ray phase-contrast imaging , 2010, Proceedings of the National Academy of Sciences.

[14]  L D Chapman,et al.  Common characteristics shared by different differential phase contrast imaging methods. , 2014, Applied optics.

[15]  Ke Li,et al.  Grating based x-ray differential phase contrast imaging without mechanical phase stepping. , 2014, Optics express.

[16]  Ziyu Wu,et al.  Reconstruction of the refractive index gradient by x-ray diffraction enhanced computed tomography , 2006, Physics in medicine and biology.

[17]  Wei Huang,et al.  Computed tomography algorithm based on diffraction-enhanced imaging setup , 2005 .

[18]  Cheng-Ying Chou,et al.  An extended diffraction-enhanced imaging method for implementing multiple-image radiography , 2007, Physics in medicine and biology.

[19]  Jun Li,et al.  Multiple‐image radiography for human soft tissue , 2006, Journal of anatomy.

[20]  A. Bravin,et al.  A simplified approach for computed tomography with an X-ray grating interferometer. , 2011, Optics express.

[21]  F. Pfeiffer,et al.  Trimodal low-dose X-ray tomography , 2012, Proceedings of the National Academy of Sciences.

[22]  Atsushi Momose,et al.  Demonstration of X-Ray Talbot Interferometry , 2003 .

[23]  Yan Wang,et al.  A novel crystal-analyzer phase retrieval algorithm and its noise property. , 2015, Journal of synchrotron radiation.

[24]  Jimpei Harada,et al.  X-ray phase contrast imaging by compact Talbot-Lau interferometer with a single transmission grating. , 2014, Optics letters.

[25]  Luigi Rigon,et al.  A three-image algorithm for hard x-ray grating interferometry. , 2013, Optics express.

[26]  Atsushi Momose,et al.  Phase Tomography by X-ray Talbot Interferometry for Biological Imaging , 2006 .

[27]  Atsushi Momose,et al.  High-speed X-ray phase imaging and X-ray phase tomography with Talbot interferometer and white synchrotron radiation. , 2009, Optics express.

[28]  Atsushi Momose,et al.  Differential Phase X-ray Imaging Microscopy with X-ray Talbot Interferometer , 2008 .

[29]  Miles N. Wernick,et al.  Extraction of extinction, refraction and absorption properties in diffraction enhanced imaging , 2003 .

[30]  O. Bunk,et al.  Hard-X-ray dark-field imaging using a grating interferometer. , 2008, Nature materials.

[31]  Franz Pfeiffer,et al.  X-ray phase imaging with a grating interferometer. , 2005, Optics express.

[32]  P. C. Diemoz,et al.  Theoretical comparison of three X-ray phase-contrast imaging techniques: propagation-based imaging, analyzer-based imaging and grating interferometry. , 2012, Optics express.

[33]  Tadashi Hattori,et al.  X-ray phase imaging: from synchrotron to hospital , 2014, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.