Hypertension and acute myocardial infarction: an overview.

History of hypertension is a frequent finding in patients with acute myocardial infarction (AMI) and its recurring association with female sex, diabetes, older age, less frequent smoking and more frequent vascular comorbidities composes a risk profile quite distinctive from the normotensive ischemic counterpart.Antecedent hypertension associates with higher rates of death and morbid events both during the early and long-term course of AMI, particularly if complicated by left ventricular dysfunction and/or congestive heart failure. Renin-angiotensin-aldosterone system blockade, through either angiotensin-converting enzyme inhibition, angiotensin II receptor blockade or aldosterone antagonism, exerts particular benefits in that high-risk hypertensive subgroup.In contrast to the negative implications carried by antecedent hypertension, higher systolic pressure at the onset of chest pain associates with lower mortality within 1 year from coronary occlusion, whereas increased blood pressure recorded after hemodynamic stabilization from the acute ischemic event bears inconsistent relationships with recurring coronary events in the long-term follow-up.Whether antihypertensive treatment in post-AMI hypertensive patients prevents ischemic relapses is uncertain. As a matter of fact, excessive diastolic pressure drops may jeopardize coronary perfusion and predispose to new acute coronary events, although the precise cause-effect mechanisms underlying this phenomenon need further evaluation.

[1]  X. Jouven,et al.  Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic Review and Meta-Analysis , 2011, Circulation.

[2]  M. Zubaid,et al.  The prevalence and outcome of hypertension in patients with acute coronary syndrome in six Middle-Eastern countries , 2011, Blood pressure.

[3]  KerstinDudas,et al.  Trends in Out-of-Hospital Deaths Due to Coronary Heart Disease in Sweden (1991 to 2006) , 2011 .

[4]  B. Gersh,et al.  Population Trends in the Incidence and Outcomes of Acute Myocardial Infarction , 2011 .

[5]  C. Cannon,et al.  What Is the Optimal Blood Pressure in Patients After Acute Coronary Syndromes?: Relationship of Blood Pressure and Cardiovascular Events in the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction (PROVE IT-TIMI) 22 Trial , 2010, Circulation.

[6]  A. Gavazzi,et al.  Prevention of left ventricular remodelling after acute myocardial infarction: an update. , 2010, Recent patents on cardiovascular drug discovery.

[7]  L. Wallentin,et al.  Medication in relation to ST-segment elevation myocardial infarction in patients with a first myocardial infarction: Swedish Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA). , 2010, Archives of internal medicine.

[8]  M. Fredrikson,et al.  Association between admission supine systolic blood pressure and 1-year mortality in patients admitted to the intensive care unit for acute chest pain. , 2010, JAMA.

[9]  W. Elliott The J-Curve Between Blood Pressure and Coronary Artery Disease or Essential Hypertension: Exactly How Essential? , 2010 .

[10]  W. Elliott Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document , 2010 .

[11]  Myeong Chan Cho,et al.  Clinical Effects of Hypertension on the Mortality of Patients with Acute Myocardial Infarction , 2009, Journal of Korean medical science.

[12]  J. Herlitz,et al.  Acute coronary syndromes--the prognostic impact of hypertension, diabetes and its combination on long-term outcome. , 2009, International journal of cardiology.

[13]  S. Yusuf,et al.  Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study , 2009, Journal of hypertension.

[14]  B. Hemmelgarn,et al.  Meta-analysis of adverse cardiovascular outcomes associated with antecedent hypertension after myocardial infarction. , 2009, The American journal of cardiology.

[15]  Giuseppe Mancia,et al.  Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document , 2009, Blood pressure.

[16]  J. F. van der Heijden [Sudden death after a myocardial infarction]. , 2009, Nederlands tijdschrift voor geneeskunde.

[17]  I. Palacios,et al.  Sex Differences in Medical Care and Early Death After Acute Myocardial Infarction , 2008, Circulation.

[18]  S. Solomon,et al.  Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study. , 2008, JACC. Cardiovascular imaging.

[19]  A. Parkhomenko,et al.  History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure , 2008, Hypertension.

[20]  E. Barrett-Connor,et al.  Prevalence of Angina in Women Versus Men: A Systematic Review and Meta-Analysis of International Variations Across 31 Countries , 2008, Circulation.

[21]  G. Melina,et al.  Differences between diabetic and non-diabetic hypertensive patients with first acute non-ST elevation myocardial infarction and predictors of in-hospital complications , 2008, Journal of cardiovascular medicine.

[22]  S. Solomon,et al.  Effect of Antecedent Hypertension and Follow-Up Blood Pressure on Outcomes After High-Risk Myocardial Infarction , 2008, Hypertension.

[23]  P. Ferdinandy,et al.  Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning , 2007, Pharmacological Reviews.

[24]  S. Pringle,et al.  The cardiovascular risk factor, left ventricular hypertrophy, is highly prevalent in stable, treated angina pectoris. , 2007, American journal of hypertension.

[25]  C. Bulpitt,et al.  On-treatment diastolic blood pressure and prognosis in systolic hypertension. , 2007, Archives of internal medicine.

[26]  A. Ahlbom,et al.  Primary risk factors influence risk of recurrent myocardial infarction/death from coronary heart disease: results from the Stockholm Heart Epidemiology Program (SHEEP) , 2007, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[27]  D. Rizzoni,et al.  Inappropriate Left Ventricular Mass Changes During Treatment Adversely Affects Cardiovascular Prognosis in Hypertensive Patients , 2007, Hypertension.

[28]  A. Camm,et al.  Prognostic value of blood pressure measured during hospitalization after acute myocardial infarction: an insight from survival trials , 2007, Journal of hypertension.

[29]  G. Mancia,et al.  Dogma Disputed: Can Aggressively Lowering Blood Pressure in Hypertensive Patients with Coronary Artery Disease Be Dangerous? , 2006, Annals of Internal Medicine.

[30]  E. Antman,et al.  Association of a History of Systemic Hypertension With Mortality, Thrombotic, and Bleeding Complications Following Non‐ST‐Segment Elevation Acute Coronary Syndrome , 2006, Journal of clinical hypertension.

[31]  G. Parodi,et al.  Heart Failure and Left Ventricular Remodeling After Reperfused Acute Myocardial Infarction in Patients With Hypertension , 2006, Hypertension.

[32]  J. Núñez,et al.  Influencia del antecedente de hipertensión arterial en los pacientes ingresados por síndrome coronario agudo sin elevación del segmento ST , 2006 .

[33]  J. Núñez,et al.  [Influence of antecedent of hypertension in patients with acute coronary syndrome without ST elevation]. , 2006, Medicina clinica.

[34]  J. Valencia,et al.  Clinical course of acute myocardial infarction in the hypertensive patient in Eastern Spain: the PRIMVAC registry. , 2006, Heart & lung : the journal of critical care.

[35]  Mark Woodward,et al.  Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies , 2005, BMJ : British Medical Journal.

[36]  L. Newby,et al.  Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical trials. , 2005, American heart journal.

[37]  M. Simoons,et al.  An unusual case of right ventricular dilatation , 2005, Heart.

[38]  G. Mancia,et al.  The association of hypertension and diabetes: prevalence, cardiovascular risk and protection by blood pressure reduction , 2005, Acta Diabetologica.

[39]  M. Barbagallo,et al.  In-hospital complications of acute myocardial infarction in hypertensive subjects. , 2005, American journal of hypertension.

[40]  T. Kahan,et al.  Left ventricular hypertrophy in hypertension: its arrhythmogenic potential , 2005, Heart.

[41]  S. Yusuf,et al.  Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study , 2004, The Lancet.

[42]  G. Lamas,et al.  Antecedent hypertension and the effect of captopril on the risk of adverse cardiovascular outcomes after acute myocardial infarction with left ventricular systolic dysfunction: Insights from the Survival and Ventricular Enlargement Trial. , 2004, American heart journal.

[43]  G. Lamas,et al.  Effect of antecedent systemic hypertension on subsequent left ventricular dilation after acute myocardial infarction (from the Survival and Ventricular Enlargement trial). , 2004, The American journal of cardiology.

[44]  B. Brendorp,et al.  Importance of a history of hypertension for the prognosis after acute myocardial infarction‐‐‐for the bucindolol evaluation in acute myocardial infarction trial (BEAT) study group , 2004, Clinical cardiology.

[45]  J. Cruickshank Antihypertensive Treatment and the J-curve , 2000, Cardiovascular Drugs and Therapy.

[46]  V. Boyko,et al.  Hospital and 1-year outcome after acute myocardial infarction in patients with diabetes mellitus and hypertension , 2003, Journal of Human Hypertension.

[47]  K. Eagle,et al.  Comparison of patients with acute coronary syndrome with and without systemic hypertension. , 2003, The American journal of cardiology.

[48]  A. Moss,et al.  History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients , 2003, Hypertension.

[49]  S. Solomon,et al.  Left ventricular hypertrophy and the risk of subsequent left ventricular remodeling following myocardial infarction. , 2003, The American journal of cardiology.

[50]  R. Collins,et al.  Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies , 2002, The Lancet.

[51]  J. Ferrières,et al.  Hypertension control at hospital discharge after acute coronary event: influence on cardiovascular prognosis—the PREVENIR study , 2002, Heart.

[52]  S. Yusuf Two decades of progress in preventing vascular disease , 2002, The Lancet.

[53]  B. Psaty,et al.  Predictors of subsequent coronary events, stroke, and death among survivors of first hospitalized myocardial infarction. , 2002, Journal of clinical epidemiology.

[54]  C. Frampton,et al.  Antecedent hypertension and heart failure after myocardial infarction. , 2002, Journal of the American College of Cardiology.

[55]  M. Nieminen,et al.  For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group , 2022 .

[56]  P. Toutouzas,et al.  In-hospital mortality of habitual cigarette smokers after acute myocardial infarction; the "smoker's paradox" in a countrywide study. , 2001, European heart journal.

[57]  P. Okin,et al.  Prognostic implications of left ventricular hypertrophy. , 2001, American heart journal.

[58]  E Picano,et al.  Diagnosis of myocardial ischemia in hypertensive patients. , 2001, Journal of hypertension.

[59]  V. Palmieri,et al.  Diastolic Dysfunction in Arterial Hypertension , 2001, Journal of clinical hypertension.

[60]  Ivar AURSNES, Knud Landmark More Non-Q-wave Myocardial Infarctions but Similar Infarct Sizes in Patients with Hypertension , 2000, Blood pressure.

[61]  S. Ball,et al.  The prognostic significance of a history of systemic hypertension in patients randomised to either placebo or ramipril following acute myocardial infarction: evidence from the AIRE study , 1999, Journal of Human Hypertension.

[62]  V. Boyko,et al.  Relation of early and one-year outcome after acute myocardial infarction to systemic arterial blood pressure on admission. , 1999, The American journal of cardiology.

[63]  A. Bignamini,et al.  Effects of the administration of an angiotensin-converting enzyme inhibitor during the acute phase of myocardial infarction in patients with arterial hypertension. SMILE Study Investigators. Survival of Myocardial Infarction Long-term Evaluation. , 1999, American journal of hypertension.

[64]  E. Arnesen,et al.  Preinfarction blood pressure and smoking are determinants for a fatal outcome of myocardial infarction: a prospective analysis from the Finnmark Study. , 1998, Archives of internal medicine.

[65]  P. Palatini,et al.  Prognostic significance of hypertension and albuminuria for early mortality after acute myocardial infarction , 1998, Journal of hypertension.

[66]  L. Køber,et al.  Long-term prognosis after acute myocardial infarction in patients with a history of arterial hypertension , 1998 .

[67]  L. Køber,et al.  Long-term prognosis after acute myocardial infarction in patients with a history of arterial hypertension. TRACE study group. , 1998, European heart journal.

[68]  D. Levy,et al.  Antecedent hypertension confers increased risk for adverse outcomes after initial myocardial infarction. , 1997, Hypertension.

[69]  L. Wilhelmsen,et al.  Serum cholesterol and long-term prognosis in middle-aged men with myocardial infarction and angina pectoris. A 16-year follow-up of the Primary Prevention Study in Göteborg, Sweden. , 1997, European heart journal.

[70]  E. Barrett-Connor Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel Keys Lecture. , 1997, Circulation.

[71]  R. Virmani,et al.  Effect of hypertension and cardiac hypertrophy on coronary artery morphology in sudden cardiac death. , 1996, Circulation.

[72]  R. Califf,et al.  Relation of Increased Arterial Blood Pressure to Mortality and Stroke in the Context of Contemporary Thrombolytic Therapy for Acute Myocardial Infarction , 1996, Annals of Internal Medicine.

[73]  J. Ranstam,et al.  Incidence of myocardial infarction in elderly men being treated with antihypertensive drugs: population based cohort study , 1996, BMJ.

[74]  A. Maggioni,et al.  Prognostic value of a history of hypertension in 11483 patients with acute myocardial infarction treated with thrombolysis , 1996 .

[75]  A. Maggioni,et al.  Prognostic value of a history of hypertension in 11,483 patients with acute myocardial infarction treated with thrombolysis. GISSI-2 Investigators. Gruppo Italiano per lo Studio della, Sopravvivena nell'Infarto Miocardico. , 1996, Journal of hypertension.

[76]  J. Herlitz,et al.  Five-year prognosis after acute myocardial infarction in relation to a history of hypertension. , 1996, American journal of hypertension.

[77]  J. Cutler,et al.  Blood Pressure and Mortality Among Men With Prior Myocardial Infarction , 1995 .

[78]  P. Macfarlane,et al.  Factors determining case fatality in myocardial infarction "who dies in a heart attack"? , 1995, British heart journal.

[79]  P Whelton,et al.  Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. , 1995, Hypertension.

[80]  J. Cutler,et al.  Blood pressure and mortality among men with prior myocardial infarction. Multiple Risk Factor Intervention Trial Research Group. , 1995, Circulation.

[81]  J. Remes Neuroendocrine activation after myocardial infarction. , 1994, British heart journal.

[82]  A. Maggioni,et al.  A simple electrocardiographic predictor of the outcome of patients with acute myocardial infarction treated with a thrombolytic agent. A Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2)-Derived Analysis. , 1994, Journal of the American College of Cardiology.

[83]  L. Rossi,et al.  Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease. , 1994, The American journal of cardiology.

[84]  D. O'Gorman,et al.  The Coronary Circulation in Cardiac Hypertrophy , 1993, Journal of cardiovascular pharmacology.

[85]  D. Reed,et al.  Determinants of the prognosis after a first myocardial infarction in a migrant Japanese population. The Honolulu Heart Program. , 1993, Circulation.

[86]  P. Ganz,et al.  Hypertension and Left Ventricular Hypertrophy Are Associated With Impaired Endothelium‐Mediated Relaxation in Human Coronary Resistance Vessels , 1993, Circulation.

[87]  J. Herlitz,et al.  Prognosis in hypertensives with acute myocardial infarction , 1992, Journal of hypertension.

[88]  U. Goldbourt,et al.  Long-term prognosis after acute myocardial infarction in patients with left ventricular hypertrophy on the electrocardiogram☆ , 1992 .

[89]  S. Behar,et al.  Long-term prognosis after acute myocardial infarction in patients with left ventricular hypertrophy on the electrocardiogram. SPRINT Study Group. , 1992, The American journal of cardiology.

[90]  R. D'Agostino,et al.  Relation of low diastolic blood pressure to coronary heart disease death in presence of myocardial infarction: the Framingham Study. , 1991, BMJ.

[91]  C. Mulrow,et al.  The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous? , 1991, JAMA.

[92]  R. Collins,et al.  Blood pressure, stroke, and coronary heart disease Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context , 1990, The Lancet.

[93]  D. Levy,et al.  Prognostic significance of the electrocardiogram after Q wave myocardial infarction. The Framingham Study. , 1990, Circulation.

[94]  J. Ghali,et al.  Left ventricular hypertrophy is associated with worse survival independent of ventricular function and number of coronary arteries severely narrowed. , 1990, The American journal of cardiology.

[95]  O. Frank,et al.  Women and tobacco. , 1990, World health forum.

[96]  R. Kleiger,et al.  Clinical significance and prognostic importance of left ventricular hypertrophy in non-Q-wave acute myocardial infarction. , 1988, The American journal of cardiology.

[97]  P. Macfarlane,et al.  The role of risk factors in heart attacks occurring in men with pre-existing ischaemic heart disease. , 1988, British heart journal.

[98]  S. Willich,et al.  Factors leading to shorter survival after acute myocardial infarction in patients ages 65 to 75 years compared with younger patients. , 1988, The American journal of cardiology.

[99]  R. D'Agostino,et al.  Hypertension, Antihypertensive Treatment, and Sudden Coronary Death The Framingham Study , 1988, Hypertension.

[100]  M. Pepi,et al.  Cardiac hypertrophy in hypertension. Repolarization abnormalities elicited by rapid lowering of pressure. , 1988, Hypertension.

[101]  M. Sprynger,et al.  Hemodynamic profile of patients with acute myocardial infarction at risk of infarct expansion. , 1987, The American journal of cardiology.

[102]  J. Cruickshank,et al.  BENEFITS AND POTENTIAL HARM OF LOWERING HIGH BLOOD PRESSURE , 1987, The Lancet.

[103]  E. Barrett-Connor,et al.  Prognostic Factors for Mortality in a Population-based Study of Men and Women With a History of Heart Disease , 1986 .

[104]  S. Forman Blood pressure in survivors of myocardial infarction , 1984 .

[105]  Blood pressure in survivors of myocardial infarction. The Coronary Drug Project Research Group. , 1984, Journal of the American College of Cardiology.

[106]  M. Hobbs,et al.  Long-term prognosis after recovery from myocardial infarction: a nine year follow-up of the Perth Coronary Register. , 1983, Circulation.

[107]  L. Elveback,et al.  Coronary heart disease in residents of Rochester, Minnesota, 1950-1975. III. Effect of hypertension and its treatment on survival of patients with coronary artery disease. , 1983, Mayo Clinic proceedings.

[108]  Daniel L. McGee,et al.  Blood pressure and survival after myocardial infarction: the Framingham study. , 1980, The American journal of cardiology.

[109]  A. Vedin,et al.  Influence of a myocardial infarction on blood pressure and serum cholesterol. , 2009, Acta medica Scandinavica.

[110]  I. Stewart RELATION OF REDUCTION IN PRESSURE TO FIRST MYOCARDIAL INFARCTION IN PATIENTS RECEIVING TREATMENT FOR SEVERE HYPERTENSION , 1979, The Lancet.

[111]  T. Gibson Blood pressure levels in acute myocardial infarction. , 1978, American heart journal.

[112]  I. Salti,et al.  PHENYTOIN IN BENIGN INSULINOMA , 1976, The Lancet.

[113]  C. W. Frank,et al.  Prognosis of women with newly diagnosed coronary heart disease--a comparison with course of disease among men. , 1973, American journal of public health.

[114]  C. W. Frank,et al.  Prognosis of men after first myocardial infarction: mortality and first recurrence in relation to selected parameters. , 1968, American journal of public health and the nation's health.

[115]  T. Killip,et al.  Treatment of myocardial infarction in a coronary care unit. A two year experience with 250 patients. , 1967, The American journal of cardiology.

[116]  S. Pell,et al.  IMMEDIATE MORTALITY AND FIVE-YEAR SURVIVAL OF EMPLOYED MEN WITH A FIRST MYOCARDIAL INFARCTION. , 1964, The New England journal of medicine.