Synthesis and Evaluation of Anticancer Activity of O-allylchalcone

A large number of novel O-allylchalcones were synthesized by Claisen Schmidt condensation reaction of O-allylvanillin 3 with appropriate substituted acetophenones 4a-h. These model chalcones 5a-h and their precursor O-allylvanillin were screened for their in vitro cytotoxic activity against four human cancer cell lines. The most potent compound in this series with the IC 50 values below or around 10 µM were 5f against THP-1 cells (10.42 µM) and 5g against THP-1 (4.76 µM), DU-145 (5.21 µM), HL60 (7.90 µM), Hep-G2 (10.12 µM) and MCF-7 (10.32 µM).

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