Place of Colistin-Rifampicin Association in the Treatment of Multidrug-Resistant Acinetobacter Baumannii Meningitis: A Case Study

Treatment of Acinetobacter baumannii meningitis is an important challenge due to the accumulation of resistance of this bacteria and low meningeal diffusion of several antimicrobial requiring use of an antimicrobial effective combination to eradicate these species. We report a case of Acinetobacter baumannii multidrug-resistant nosocomial meningitis which was successfully treated with intravenous and intrathecal colistin associated with rifampicin.

[1]  A. Andreou,et al.  Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis and meningitis with intraventricular colistin after application of a loading dose: a case series. , 2013, International journal of antimicrobial agents.

[2]  Matteo Bassetti,et al.  New treatment options against gram-negative organisms , 2011, Critical care.

[3]  Lisa L Maragakis,et al.  Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  F. Pérez,et al.  Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters: assessment of different treatments. , 2008, The Journal of antimicrobial chemotherapy.

[5]  J. Balík,et al.  Comparison of postsurgical and community acquired bacterial meningitis--analysis of 372 cases within a nationwide survey. , 2007, Neuro endocrinology letters.

[6]  E. Alp,et al.  Acinetobacter baumannii meningitis in post-neurosurgical patients: clinical outcome and impact of carbapenem resistance. , 2007, The Journal of antimicrobial chemotherapy.

[7]  P. Kisac,et al.  Postsurgical meningitis caused by Acinetobacter baumannii associated with high mortality. , 2007, Neuro endocrinology letters.

[8]  G. Bersani,et al.  Mood disorder in a patient with Smith-Magenis syndrome: a case report. , 2007, Neuro endocrinology letters.

[9]  J. Pachón,et al.  Prevention of rifampicin resistance in Acinetobacter baumannii in an experimental pneumonia murine model, using rifampicin associated with imipenem or sulbactam. , 2006, The Journal of antimicrobial chemotherapy.

[10]  D. Hospenthal,et al.  Treatment of multidrug resistant Acinetobacter , 2005, Current opinion in infectious diseases.

[11]  M. Falagas,et al.  Nephrotoxicity of intravenous colistin: a prospective evaluation. , 2005, International journal of antimicrobial agents.

[12]  M. Falagas,et al.  Colistin treatment in patients with ICU-acquired infections caused by multiresistant Gram-negative bacteria: the renaissance of an old antibiotic. , 2005, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[13]  Hsin-Pai Chen,et al.  Clinical significance of Acinetobacter species isolated from cerebrospinal fluid , 2005, Scandinavian journal of infectious diseases.

[14]  M. Athanasiou,et al.  Intravenous colistin in the treatment of sepsis from multiresistant Gram-negative bacilli in critically ill patients , 2003, Critical care.

[15]  J. Garnacho-Montero,et al.  Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  J. Pachón,et al.  Cerebrospinal Fluid Penetration and Pharmacokinetic/Pharmacodynamic Parameters of Intravenously Administered Colistin in a Case of Multidrug-Resistant Acinetobacter baumannii Meningitis , 2002, European Journal of Clinical Microbiology and Infectious Diseases.

[17]  E. Giamarellos‐Bourboulis,et al.  Interactions of colistin and rifampin on multidrug-resistant Acinetobacter baumannii. , 2001, Diagnostic microbiology and infectious disease.

[18]  A. Kapil,et al.  Nosocomial infections due to Acinetobacter baumannii in a neurosurgery ICU. , 2001, Neurology India.

[19]  Víctor Asensi,et al.  Meningitis postquirúrgica por Acinetobacter baumannii: estudio de 22 casos y revisión de la literatura , 2001 .

[20]  A. Levin,et al.  Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. , 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[21]  V. Caviness,et al.  Acute bacterial meningitis in adults. A review of 493 episodes. , 1993, The New England journal of medicine.