A. Grothey, A. Sobrero, J.A. Meyerhardt, T. Yoshino, J. Paul, J. Taieb, I. Souglakos, R. Kerr, R. Labianca, A.F. Shields, F. Bonnetain, T. Yamanaka, I. Boukovinas, Q. Shi, J.P. Meyers, D. Niedzwiecki, V. Torri, D.J. Sargent, T. André, T. Iveson Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA, Medical Oncology Unit, IRCCS San Martino, Genoa, Italy, Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan, Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK, Gastroenterology and Digestive Oncology, Hôpital Européen Georges-Pompidou, Sorbonne Paris Cité Université Paris Descartes, Paris, France, Dept of Medical Oncology, University Hospital of Heraklion (PAGNI), Heraklion, Greece, Dept of Oncology, Churchill Hospital University of Oxford, Oxford, UK, Dept of Oncology, Ospedale Papa Giovanni XXIII, Bergamo, Italy, Dept of Oncology, Karmanos Cancer Institute, Detroit, MI, USA, Methodological and Quality of Life Unit in Oncology (INSERM UMR 1098), University Hospital Jean Minjoz, Besançon, France, Medical Course Biostatistics, Yokohama City University School of Medicine, Yokohama, Japan, Medical Oncology Unit, Bioclinic Thessaloniki, Thessaloniki, Greece, Dept of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA, Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA, Dept of Oncology, IRRCS Mario Negri Institute for Pharmacological Research, Milan, Italy, Medical Oncology, Hopital Saint Antoine, Paris, France, Dept of Medical Oncology, University Hospital Southampton, Southampton, UK