Electrochemical bisphenol A sensor based on N-doped graphene sheets.

Bisphenol A (BPA), which could disrupt endocrine system and cause cancer, has been considered as an endocrine disruptor. Therefore, it is very important and necessary to develop a sensitive and selective method for detection of BPA. Herein, nitrogen-doped graphene sheets (N-GS) and chitosan (CS) were used to prepare electrochemical BPA sensor. Compared with graphene, N-GS has favorable electron transfer ability and electrocatalytic property, which could enhance the response signal towards BPA. CS also exhibits excellent film forming ability and improves the electrochemical behavior of N-GS modified electrode. The sensor exhibits a sensitive response to BPA in the range of 1.0×10(-8)-1.3×10(-6) mol L(-1) with a low detection limit of 5.0×10(-9) mol L(-1) under the optimal conditions. Finally, this proposed sensor was successfully employed to determine BPA in water samples with satisfactory results.

[1]  Y. Liu,et al.  Nitrogen-doped graphene as efficient metal-free electrocatalyst for oxygen reduction in fuel cells. , 2010, ACS nano.

[2]  P. Ajayan,et al.  Synthesis of nitrogen-doped graphene films for lithium battery application. , 2010, ACS nano.

[3]  S. Woo,et al.  Electrochemical oxygen reduction on nitrogen doped graphene sheets in acid media , 2010 .

[4]  Huanshun Yin,et al.  Preparation and characteristic of cobalt phthalocyanine modified carbon paste electrode for bisphenol A detection , 2009 .

[5]  R. Ito,et al.  Determination of bisphenol A in river water and body fluid samples by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[6]  Dan Wu,et al.  Ultrasensitive electrochemical immunoassay for BRCA1 using BMIM·BF₄-coated SBA-15 as labels and functionalized graphene as enhancer. , 2011, Biomaterials.

[7]  T. Łuczak.  Preparation and characterization of the dopamine film electrochemically deposited on a gold template and its applications for dopamine sensing in aqueous solution , 2008 .

[8]  Liang Fang,et al.  Controllable N-doping of graphene. , 2010, Nano letters.

[9]  W. Lu,et al.  Improved synthesis of graphene oxide. , 2010, ACS nano.

[10]  Xiaohui Zhou,et al.  Chitosan–Fe3O4 nanocomposite based electrochemical sensors for the determination of bisphenol A , 2011 .

[11]  S. Rossi,et al.  Enzymatic determination of BPA by means of tyrosinase immobilized on different carbon carriers. , 2007, Biosensors & bioelectronics.

[12]  J. Yonekubo,et al.  Leaching of bisphenol A (BPA) to seawater from polycarbonate plastic and its degradation by reactive oxygen species. , 2003, Chemosphere.

[13]  J. Haginaka,et al.  Simultaneous determination of bisphenol A and its halogenated derivatives in river water by combination of isotope imprinting and liquid chromatography-mass spectrometry. , 2006, Journal of chromatography. A.

[14]  Yuanyuan Yang,et al.  Bisphenol A sensing based on surface molecularly imprinted, ordered mesoporous silica , 2011 .

[15]  J. Miyawaki,et al.  Preparation of nitrogen-doped graphene sheets by a combined chemical and hydrothermal reduction of graphene oxide. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[16]  H. Nohta,et al.  Liquid chromatographic determination of bisphenols based on intramolecular excimer-forming fluorescence derivatization , 2003 .

[17]  Xianggang Liu,et al.  Sensitivity and selectivity determination of BPA in real water samples using PAMAM dendrimer and CoTe quantum dots modified glassy carbon electrode. , 2010, Journal of hazardous materials.

[18]  Simultaneous nitrogen doping and reduction of graphene oxide. , 2009, Journal of the American Chemical Society.

[19]  Huanshun Yin,et al.  Electrochemical determination of bisphenol A at Mg–Al–CO3 layered double hydroxide modified glassy carbon electrode , 2010 .

[20]  Huang-Hao Yang,et al.  A graphene platform for sensing biomolecules. , 2009, Angewandte Chemie.

[21]  F. Peeters,et al.  Electric Field Activated Hydrogen Dissociative Adsorption to Nitrogen-Doped Graphene , 2010 .

[22]  Zhenghe Xu,et al.  Electrochemical detection of bisphenol A mediated by [Ru(bpy)(3)](2+) on an ITO electrode. , 2010, Journal of hazardous materials.

[23]  Florence Chapuis-Hugon,et al.  Role of molecularly imprinted polymers for selective determination of environmental pollutants--a review. , 2008, Analytica chimica acta.

[24]  Jinquan Yang,et al.  Mesoporous silica-based electrochemical sensor for sensitive determination of environmental hormone bisphenol A. , 2009, Analytica chimica acta.

[25]  Jing Xu,et al.  Amperometric biosensor based on tyrosinase immobilized onto multiwalled carbon nanotubes-cobalt phthalocyanine-silk fibroin film and its application to determine bisphenol A. , 2010, Analytica chimica acta.

[26]  Weijie Shi,et al.  Amperometric determination of bisphenol A in milk using PAMAM-Fe3O4 modified glassy carbon electrode , 2011 .

[27]  R. Car,et al.  Single Sheet Functionalized Graphene by Oxidation and Thermal Expansion of Graphite , 2007 .

[28]  Yunhui Yang,et al.  Alpha-1-fetoprotein antibody functionalized Au nanoparticles: Catalytic labels for the electrochemical detection of α-1-fetoprotein based on TiO2 nanoparticles synthesized with ionic liquid , 2009 .

[29]  C. Borrás,et al.  Electrochemical behavior of phenol in alkaline media at hydrotalcite-like clay/anionic surfactants/glassy carbon modified electrode , 2006 .

[30]  Lei Fu,et al.  Synthesis of Nitrogen‐Doped Graphene Using Embedded Carbon and Nitrogen Sources , 2011, Advanced materials.

[31]  Ursula Gundert-Remy,et al.  Bisphenol A levels in blood depend on age and exposure. , 2009, Toxicology letters.

[32]  Laura N. Vandenberg,et al.  Human exposure to bisphenol A (BPA). , 2007, Reproductive toxicology.

[33]  Yuyan Shao,et al.  Nitrogen-doped graphene and its application in electrochemical biosensing. , 2010, ACS nano.