Metrological Issues in Molecular Radiotherapy

The therapeutic effect from molecular radiation therapy (MRT), on both tumour and normal tissue, is determined by the radiation absorbed dose. Recent research indicates that as a consequence of biological variation across patients the absorbed dose can vary, for the same administered activity, by as much as two orders of magnitude. The international collaborative EURAMET-EMRP project “Metrology for molecular radiotherapy (MetroMRT)” is addressing this problem. The overall aim of the project is to develop methods of calibrating and verifying clinical dosimetry in MRT. In the present paper an overview of the metrological issues in molecular radiotherapy is provided.

[1]  K. Kossert.  Activity standardization by means of a new TDCR-Cerenkov counting technique. , 2010, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[2]  D. Bailey,et al.  Quantitative (90)Y image reconstruction in PET. , 2012, Medical physics.

[3]  Renaud Lhommel,et al.  Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[4]  Glenn D. Flux,et al.  A dose-effect correlation for radioiodine ablation in differentiated thyroid cancer , 2010, European Journal of Nuclear Medicine and Molecular Imaging.

[5]  N Lanconelli,et al.  Differences among Monte Carlo codes in the calculations of voxel S values for radionuclide targeted therapy and analysis of their impact on absorbed dose evaluations. , 2009, Medical physics.

[6]  M. D’Arienzo,et al.  Three-dimensional patient-specific dosimetry in radioimmunotherapy with 90Y-ibritumomab-tiuxetan. , 2012, Cancer biotherapy & radiopharmaceuticals.

[7]  M. Cox.  Modelling Clinical Decay Data Using Exponential Functions , 2011 .

[8]  S. Walrand,et al.  Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging? , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[9]  K. Koral,et al.  Accurate dosimetry in 131I radionuclide therapy using patient-specific, 3-dimensional methods for SPECT reconstruction and absorbed dose calculation. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  C. Thiam,et al.  Application of a stochastic TDCR model based on Geant4 for Cherenkov primary measurements. , 2010, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[11]  Michael G Stabin,et al.  OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  K. Kandagatla,et al.  Beta voxel S values for internal emitter dosimetry. , 2003, Medical physics.

[13]  Michael Ljungberg,et al.  An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[14]  H. Kestler,et al.  Molecular radiotherapy: the NUKFIT software for calculating the time-integrated activity coefficient. , 2013, Medical physics.

[15]  Michael Lassmann,et al.  Clinical radionuclide therapy dosimetry: the quest for the “Holy Gray” , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[16]  S. Standard.  GUIDE TO THE EXPRESSION OF UNCERTAINTY IN MEASUREMENT , 2006 .

[17]  P. Cassette,et al.  Radionuclide metrology using liquid scintillation counting , 2007 .

[18]  Michael G Stabin,et al.  Uncertainties in Internal Dose Calculations for Radiopharmaceuticals , 2008, Journal of Nuclear Medicine.

[19]  Jm Pereira,et al.  IMAGE QUANTIFICATION FOR RADIATION DOSE CALCULATIONS—LIMITATIONS AND UNCERTAINTIES , 2010, Health physics.

[20]  K. Abbas,et al.  Development of a primary standard for calibration of (64)Cu activity measurement systems. , 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[21]  C. Baldockb,et al.  Development of activity standard for 90 Y microspheres , 2005 .

[22]  L. Xing,et al.  Iterative image reconstruction for CBCT using edge-preserving prior. , 2008, Medical physics.

[23]  S. Vandenberghe,et al.  Comparison of yttrium-90 quantitative imaging by TOF and non-TOF PET in a phantom of liver selective internal radiotherapy , 2011, Physics in medicine and biology.

[24]  M. D’Arienzo,et al.  90Y-PET for the assessment of microsphere biodistribution after selective internal radiotherapy , 2012, Nuclear medicine communications.

[25]  M. D’Arienzo,et al.  90Y PET-based dosimetry after selective internal radiotherapy treatments , 2012, Nuclear medicine communications.