Dynamic optimization of fed-batch fermentation with constraint on wastewater discharge

Fed-batch cultures appear frequently in fermentation process in which the cell growth or product formation is sensitive to the concentration of the limiting substrate. Compared to batch cultures and continuous cultures, the operation in fed-batch mode provides an excellent means of regulating the substrate feed rate to optimize the productivity while at the same time obviating the production of unnecessary by-products. Since high concentration of substrate at the beginning of the fermentation inhibits production, fedbatch is an ideal operation mode to obtain a high production.

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