Influence of Prostaglandins

The anorexia associated with acute and chronic inflammatory or infectious conditions is poorly understood. Our objectives were to explore the anorexigenic effects of interleukin-1 (IL-1) in the rat. Recombinant human (rh) IL-1,6, murine (rm) IL-la and to a lesser extent rhIL-la significantly reduced food intake at 24.0 gg/kg i.p. but not at lower doses, in young (200-250 g) meal-fed rats on chow diets. The anorexic effect appears to be mediated by prostaglandins since pretreatment with ibuprofen completely blocked it, and a fish oil based diet abolished it, in comparison to corn oil or chow diets. Fish oil feeding also decreased basal and IL-1 stimulated prostaglandin E2 production by tissues in vitro (liver, brain, peritoneal macrophages) and in the whole body. Constant intravenous infusions of lower doses of IL-1 also diminished food intake, though intravenous boluses did not (reflecting rapid renal clearance). Chronic daily administration of IL-1 caused persistent inhibition of food intake for 7-17 d in chow and corn oil fed rats, but had no effect in fish oil fed rats. There was an attenuation of the effect (tachyphylaxis) after 7 d in corn oil and chow fed rats, but slowed weight gain and lower final weights were observed after 17-32 d of daily IL-1. Old (18-20 mo Fisher 344) rats showed less sensitivity to IL-1 induced anorexia. In conclusion, IL-1 is anorexigenic in the rat, but this is influenced by the structural form of IL-1, the route and chronicity of administration, the source of dietary fat, and the age of the animal. The ability of prior fat intake to influence the anorexic response to IL-1 represents a novel nutrient-nutrient interaction with potential therapeutic implications.

[1]  P. Weber,et al.  The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. , 1989, The New England journal of medicine.

[2]  C. Dinarello,et al.  Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits. , 1988, The American journal of physiology.

[3]  A. Cerami,et al.  Detection of circulating tumor necrosis factor after endotoxin administration. , 1988, The New England journal of medicine.

[4]  T. Ikejima,et al.  Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. , 1988, The Journal of clinical investigation.

[5]  L. Moldawer,et al.  Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines. , 1988, The American journal of physiology.

[6]  M. Lumpkin.  The regulation of ACTH secretion by IL-1. , 1987, Science.

[7]  S. Meydani,et al.  A fish oil diet retards experimental amyloidosis, modulates lymphocyte function, and decreases macrophage arachidonate metabolism in mice. , 1987, Journal of immunology.

[8]  P. Libby,et al.  Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. , 1987, Journal of immunology.

[9]  K. Feingold,et al.  Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo. , 1987, The Journal of clinical investigation.

[10]  J. Elias,et al.  Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor. , 1987, Journal of immunology.

[11]  J. Kremer,et al.  Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, controlled, crossover study. , 1987, Annals of internal medicine.

[12]  B. Beutler,et al.  Cachectin: more than a tumor necrosis factor. , 1987, The New England journal of medicine.

[13]  A. Vander,et al.  Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats , 1986, Physiology & Behavior.

[14]  A. Theologides.  Anorexins, asthenins, and cachectins in cancer. , 1986, The American journal of medicine.

[15]  A. C. Webb,et al.  Multiple biological activities of human recombinant interleukin 1. , 1986, The Journal of clinical investigation.

[16]  B. Beutler,et al.  Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1 , 1986, The Journal of experimental medicine.

[17]  A. Vander,et al.  Suppression of food intake during infection: is interleukin-1 involved? , 1985, The American journal of clinical nutrition.

[18]  J. Wang,et al.  Body composition studies in patients with the acquired immunodeficiency syndrome. , 1985, The American journal of clinical nutrition.

[19]  A. Dalgleish,et al.  SLIM DISEASE: A NEW DISEASE IN UGANDA AND ITS ASSOCIATION WITH HTLV-III INFECTION , 1985, The Lancet.

[20]  W. Langhans,et al.  Different Metabolites Might Reduce Food Intake by the Mitochondrial Generation of Reducing Equivalents , 1985, Appetite.

[21]  Robert A. Lewis,et al.  Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function , 1985 .

[22]  D. Robinson,et al.  Dietary fish oil augments the induction of arthritis in rats immunized with type II collagen. , 1984, Journal of immunology.

[23]  C. Dinarello,et al.  Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/interleukin 1. , 1982, Journal of immunology.

[24]  S. Meydani,et al.  Effect of zinc deficiency on prostaglandin synthesis in different organs of the rat. , 1982, The Journal of nutrition.

[25]  M. Russek.  Current status of the hepatostatic theory of food intake control , 1981, Appetite.

[26]  W. Powell.  Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. , 1980, Prostaglandins.

[27]  A. Robert.  Cytoprotection by prostaglandins. , 1979, Gastroenterology.

[28]  M. Kluger,et al.  Protein deficiency: its effects on body temperature in health and disease states. , 1979, The American journal of clinical nutrition.

[29]  I. Hornstein.  Impact of infection on nutritional status: introductory remarks , 1977 .

[30]  D. Quartermain,et al.  Short-term and long-term components in the regulation of food intake: evidence for a modulatory role of carbohydrate status. , 1977, The American journal of clinical nutrition.

[31]  J. Pace,et al.  The effect of bacterial infections on ketone concentrations in rat liver and blood and on free fatty acid concentrations in rat blood. , 1976, Metabolism: clinical and experimental.

[32]  A. Robert.  An intestinal disease produced experimentally by a prostaglandin deficiency. , 1975, Gastroenterology.

[33]  K. Larsen.  Creatinine assay by a reaction-kinetic principle. , 1972, Clinica chimica acta; international journal of clinical chemistry.

[34]  G. Leveille.  The long-term effects of meal-eating on lipogenesis, enzyme activity, and longevity in the rat. , 1972, The Journal of nutrition.

[35]  J. Tepperman,et al.  Effects of antecedent food intake pattern on hepatic lipogenesis. , 1958, The American journal of physiology.

[36]  C. Dinarello.  Interleukin-1 and its biologically related cytokines. , 1989, Advances in immunology.

[37]  R. Chlebowski.  Significance of altered nutritional status in acquired immune deficiency syndrome (AIDS). , 1985, Nutrition and cancer.

[38]  Sullivan Ac,et al.  Mechanisms of appetite modulation by drugs. , 1985 .

[39]  P. Hotez,et al.  Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: the role of cachectin (tumor necrosis factor). , 1985, Immunology letters.

[40]  W. Beisel,et al.  Metabolic response to infection. , 1975, Annual review of medicine.