Bioreversibly crosslinked polyplexes of PEI and high molecular weight PEG show extended circulation times in vivo.
暂无分享,去创建一个
Oliver Germershaus | Michael Neu | T. Kissel | M. Neu | Oliver Germershaus | M. Béhé | Thomas Kissel | Martin Behe | O. Germershaus | Michael Neu
[1] A. Schätzlein,et al. PEI-based vesicle-polymer hybrid gene delivery system with improved biocompatibility. , 2004, International journal of pharmaceutics.
[2] C. Ahn,et al. Biodegradable poly(ethylenimine) for plasmid DNA delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.
[3] Yuichi Yamasaki,et al. Freeze-dried formulations for in vivo gene delivery of PEGylated polyplex micelles with disulfide crosslinked cores to the liver. , 2005, Journal of controlled release : official journal of the Controlled Release Society.
[4] A. Aigner,et al. Efficiency of polyethylenimines and polyethylenimine-graft-poly (ethylene glycol) block copolymers to protect oligonucleotides against enzymatic degradation. , 2004, European journal of pharmaceutics and biopharmaceutics.
[5] Thomas Kissel,et al. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. , 2003, Biomaterials.
[6] S. Armes,et al. Influence of polymer architecture on the structure of complexes formed by PEG-tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide. , 2002, Journal of controlled release : official journal of the Controlled Release Society.
[7] L. Marky,et al. A Thermodynamic Characterization of the Interaction of a Cationic Copolymer with DNA , 2001 .
[8] A. Kabanov,et al. Interpolyelectrolyte and block ionomer complexes for gene delivery: physico-chemical aspects. , 1998, Advanced drug delivery reviews.
[9] L. Seymour,et al. Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo , 2001, Gene Therapy.
[10] L. Seymour,et al. Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors. , 2002, Journal of the American Chemical Society.
[11] Gert Storm,et al. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system , 1995 .
[12] U. Bakowsky,et al. Stabilized nanocarriers for plasmids based upon cross-linked poly(ethylene imine). , 2006, Biomacromolecules.
[13] W. Tseng,et al. The role of dextran conjugation in transfection mediated by dextran‐grafted polyethylenimine , 2004, The journal of gene medicine.
[14] D. Fischer,et al. Effect of poly(ethylene imine) molecular weight and pegylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[15] A. Mikos,et al. Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. , 1999, Journal of biomedical materials research.
[16] R. Duncan,et al. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. , 1999, International journal of pharmaceutics.
[17] L. Monaco,et al. Nanoscopic structure of DNA condensed for gene delivery. , 1997, Nucleic acids research.
[18] H. Too,et al. Polyethylene glycol modified polyethylenimine for improved CNS gene transfer: effects of PEGylation extent. , 2003, Biomaterials.
[19] J. Kopeček,et al. Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. , 2003, Bioconjugate chemistry.
[20] Wenjin Guo,et al. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. , 2001, Bioconjugate chemistry.
[21] D. Fischer,et al. Synthesis, Characterization, and Biocompatibility of Polyethylenimine-graft-poly(ethylene glycol) Block Copolymers , 2002 .
[22] Yuichi Yamasaki,et al. Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression. , 2004, Journal of the American Chemical Society.
[23] J. Behr,et al. A model for non‐viral gene delivery: through syndecan adhesion molecules and powered by actin , 2004, The journal of gene medicine.
[24] D. Scherman,et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[25] Mark E. Davis,et al. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. , 2004, European journal of cell biology.
[26] M. Davies,et al. The macrostopper route: A new synthesis concept leading exclusively to diblock copolymers with enhanced DNA condensation potential , 2002 .
[27] Kenneth A Howard,et al. Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.
[28] K. Gupta,et al. Polyethylenimine nanoparticles as efficient transfecting agents for mammalian cells. , 2006, Journal of controlled release : official journal of the Controlled Release Society.
[29] L. Barrett,et al. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery , 1999, Gene Therapy.
[30] D. Fischer,et al. A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity , 1999, Pharmaceutical Research.
[31] K. Ulbrich,et al. Polymer‐coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction , 2004, The journal of gene medicine.
[32] Y. Li,et al. Characterization of commercially available and synthesized polyethylenimines for gene delivery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.
[33] D. Fischer,et al. Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. , 2002, Bioconjugate chemistry.
[34] K. Mechtler,et al. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. , 1996, Human gene therapy.
[35] J. Kopeček,et al. PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. , 2005, Bioconjugate chemistry.
[36] Nicholas A Peppas,et al. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. , 2006, International journal of pharmaceutics.
[37] M. Ogris,et al. PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery , 1999, Gene Therapy.
[38] Clive J Roberts,et al. Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. , 2002, Bioconjugate chemistry.
[39] M. Glodde,et al. Physiochemical properties of low and high molecular weight poly(ethylene glycol)-grafted poly(ethylene imine) copolymers and their complexes with oligonucleotides. , 2006, Biomacromolecules.
[40] W. Seeger,et al. Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. , 2005, Journal of controlled release : official journal of the Controlled Release Society.
[41] D. Fischer,et al. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives , 2005, The journal of gene medicine.
[42] H. von Briesen,et al. Human serum albumin-polyethylenimine nanoparticles for gene delivery. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[43] K. Ulbrich,et al. Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo , 2002, The journal of gene medicine.
[44] O. Ludkovski,et al. Stabilized plasmid-lipid particles for systemic gene therapy , 2000, Gene Therapy.
[45] Martin C Garnett,et al. The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes. , 2004, Journal of controlled release : official journal of the Controlled Release Society.
[46] M. Whitlow,et al. Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: a comparison of conjugation chemistries and compounds. , 1999, Bioconjugate chemistry.
[47] Y. Oh,et al. Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexes , 2001, Gene Therapy.
[48] T. Kissel,et al. Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. , 2006, Bioconjugate chemistry.
[49] Jung-Ki Park,et al. Effect of polyethylene glycol on gene delivery of polyethylenimine. , 2003, Biological & pharmaceutical bulletin.
[50] M. Hashida,et al. The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake , 1995, Pharmaceutical Research.
[51] R. Langer,et al. Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis , 2005, The journal of gene medicine.
[52] D. Fischer,et al. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. , 2003, Journal of controlled release : official journal of the Controlled Release Society.
[53] D. Fischer,et al. The Structure of PEG-Modified Poly(Ethylene Imines) Influences Biodistribution and Pharmacokinetics of Their Complexes with NF-κB Decoy in Mice , 2002, Pharmaceutical Research.
[54] D. Crommelin,et al. Steric stabilization of poly(2‐(dimethylamino)ethyl methacrylate)‐based polyplexes mediates prolonged circulation and tumor targeting in mice , 2004, The journal of gene medicine.
[55] T. Mosmann. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.
[56] Joel A Swanson,et al. Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities. , 2003, Advanced drug delivery reviews.
[57] J. Hagstrom,et al. Caged DNA does not aggregate in high ionic strength solutions. , 1999, Bioconjugate chemistry.
[58] P. Shaw,et al. Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation. , 1999, Life sciences.
[59] D. Lauffenburger,et al. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. , 2000, Biotechnology and bioengineering.