Fully Convolutional Multi-Scale ScSE-DenseNet for Automatic Pneumothorax Segmentation in Chest Radiographs

Automatic pneumothorax segmentation on chest X-ray images is very crucial for diagnosis and treatment as large pneumothorax could be fatal. The pneumothorax segmentation is challenging, as some small pneumothoraces can be subtle, and may overlap with the ribs and clavicles. Meanwhile, the shape variation of pneumothorax is also very large, which also makes the segmentation more difficult. In this paper, we propose a novel automated pneumothorax segmentation framework which consists of three modules: 1) a fully convolutional DenseNet (FC-DenseNet), 2) a spatial and channel squeeze and excitation module (scSE), and 3) a multi-scale module. In order to improve boundary segmentation accuracy, a novel spatial weighted cross-entropy loss function is proposed, which penalize the target, background and contour pixels with different weights. Extensive experiments are conducted on the 2213 chest X-ray images of testing data and the results suggest that proposed segmentation algorithm outperforms the state-of-the-art methods in terms of mean pixel-wise accuracy (MPA) of $0.93\pm 0.13$ and dice similarity coefficient (DSC) of $0.92\pm 0.14$ etc. Accordingly, the effectiveness of our method is corroborated.

[1]  Roberto Cipolla,et al.  SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[2]  George Papandreou,et al.  Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation , 2018, ECCV.

[3]  Jian Sun,et al.  Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification , 2015, 2015 IEEE International Conference on Computer Vision (ICCV).

[4]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[5]  Yoshua Bengio,et al.  The One Hundred Layers Tiramisu: Fully Convolutional DenseNets for Semantic Segmentation , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW).

[6]  Hung-Min Sun,et al.  Effective Pneumothorax Detection for Chest X-Ray Images Using Local Binary Pattern and Support Vector Machine , 2018, Journal of healthcare engineering.

[7]  Ganapathy Krishnamurthi,et al.  Fully convolutional multi‐scale residual DenseNets for cardiac segmentation and automated cardiac diagnosis using ensemble of classifiers , 2018, Medical Image Anal..

[8]  Nassir Navab,et al.  Concurrent Spatial and Channel Squeeze & Excitation in Fully Convolutional Networks , 2018, MICCAI.

[9]  Kun Yu,et al.  DenseASPP for Semantic Segmentation in Street Scenes , 2018, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[10]  A. Arnold,et al.  Management of spontaneous pneumothorax: British Thoracic Society pleural disease guideline 2010 , 2010, Thorax.