Therapeutic hypothermia after cardiac arrest--once again.

The authors reexamine the issue of therapeutic hypothermia after cardiac arrest and discuss the outstanding issues. In an addendum they discuss the analytic strategy used in a separate paper with respect to competing risks. (non-author abstract)

[1]  S Greenland,et al.  Basic problems in interaction assessment. , 1993, Environmental health perspectives.

[2]  George A. Wells,et al.  Advanced Cardiac Life Support in Out-of-Hospital Cardiac Arrest , 2004 .

[3]  Lemuel A Moyé,et al.  Multiple Analyses in Clinical Trials: Fundamentals for Investigators , 2003 .

[4]  S. Bernard.  Hypothermia improves outcome from cardiac arrest. , 2005, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[5]  E. Topol,et al.  Clinical trials--multiple treatments, multiple end points, and multiple lessons. , 2003, JAMA.

[6]  Robert Gray,et al.  A Proportional Hazards Model for the Subdistribution of a Competing Risk , 1999 .

[7]  Alan D. Lopez,et al.  Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. , 2002, The New England journal of medicine.

[8]  S. Bernard,et al.  Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. , 2002, The New England journal of medicine.

[9]  R. Glynn,et al.  Methods to evaluate risks for composite end points and their individual components. , 2004, Journal of clinical epidemiology.

[10]  J L Moran,et al.  Reporting of clinical trials using group sequential methods. , 2001, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[11]  J L Moran,et al.  Hypothermia as therapy in cerebral injury. , 2002, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[12]  Karen Smith,et al.  Treatment of Comatose Survivors of Out-of-hospital Cardiac Arrest With Induced Hypothermia , 2003 .

[13]  R. D'Agostino,et al.  Efficacy endpoint selection and multiplicity adjustment methods in clinical trials with inherent multiple endpoint issues , 2003, Statistics in medicine.

[14]  K. Polderman.  Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidence , 2004, Intensive Care Medicine.

[15]  S Greenland,et al.  Tests for interaction in epidemiologic studies: a review and a study of power. , 1983, Statistics in medicine.

[16]  M H Weil,et al.  Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. , 2003, Circulation.

[17]  S. Bernard,et al.  Therapeutic hypothermia after cardiac arrest. , 2006, Neurologic clinics.

[18]  M. Holzer,et al.  The influence of chronic prearrest health conditions on mortality and functional neurological recovery in cardiac arrest survivors. , 1998, The American journal of medicine.

[19]  J L Moran,et al.  Selective digestive decontamination: once again. , 2003, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[20]  Nick Freemantle,et al.  Composite outcomes in randomized trials: greater precision but with greater uncertainty? , 2003, JAMA.

[21]  John Bryant,et al.  Analysis of Cause-Specific Events in Competing Risks Survival Data , 2003, Advances in Survival Analysis.

[22]  K. Polderman,et al.  Application of therapeutic hypothermia in the intensive care unit , 2004, Intensive Care Medicine.

[23]  Y. Michotte,et al.  Mild hypothermia induced by a helmet device: a clinical feasibility study. , 2001, Resuscitation.

[24]  John P. Klein,et al.  Inference for Competing Risks , 2003, Advances in Survival Analysis.

[25]  S. Yusuf,et al.  Strengths and limitations of meta-analysis: larger studies may be more reliable. , 1997, Controlled clinical trials.

[26]  G. Skowronski.  Therapeutic hypothermia after cardiac arrest--not so fast. , 2005, Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine.

[27]  J. Ware,et al.  Therapeutic hypothermia following cardiac arrest: class I evidence? , 2004, Intensive Care Medicine.

[28]  Patricia J. Solomon,et al.  Application of therapeutic hypothermia in the intensive care unit , 2004, Intensive Care Medicine.

[29]  M. Holzer,et al.  Hypothermia for neuroprotection after cardiac arrest: Systematic review and individual patient data meta-analysis , 2005, Critical care medicine.

[30]  S. Chevret,et al.  Improving estimates of event incidence over time in populations exposed to other events: application to three large databases. , 2003, Journal of clinical epidemiology.

[31]  R. Gray.  A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk , 1988 .