Multimodal polymeric contrast agents for MRI and fluorescence imaging in the management of cancer

The multimodal polymeric contrast agents for MRI and fluorescence imaging in the management of cancer are discussed. The paper presents preliminary data that suggest that a simple experimental protocol can provide at least an index of the permeability parameter if not the absolute permeability itself.

[1]  Viktor Novikov,et al.  Tumor microvascular changes in antiangiogenic treatment: Assessment by magnetic resonance contrast media of different molecular weights , 2004, Journal of magnetic resonance imaging : JMRI.

[2]  O Nalcioglu,et al.  Investigation of longitudinal vascular changes in control and chemotherapy‐treated tumors to serve as therapeutic efficacy predictors , 1999, Journal of magnetic resonance imaging : JMRI.

[3]  Ralph Weissleder,et al.  A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. , 2003, Cancer research.

[4]  D Artemov,et al.  Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts. , 2001, Neoplasia.

[5]  D M Shames,et al.  Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small-molecular contrast media. , 1998, AJR. American journal of roentgenology.

[6]  N. van Bruggen,et al.  Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. , 1998, Cancer investigation.

[7]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[8]  Anthony J. Durkin,et al.  In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration. , 2003, Applied optics.

[9]  E. Conant,et al.  Optical imaging as an adjunct to sonograph in differentiating benign from malignant breast lesions. , 2000, Journal of biomedical optics.

[10]  E. Uzgiris The Role of Molecular Conformation on Tumor Uptake of Polymeric Contrast Agents , 2004, Investigative radiology.

[11]  J. Ripoll,et al.  In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green. , 2003, Medical physics.