Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta‐analysis

Background  Low‐grade inflammation has been increasingly implicated in the pathophysiology of irritable bowel syndrome (IBS). Imbalances of pro‐ and anti‐inflammatory cytokines and polymorphisms in cytokine genes have been reported in IBS; however, these findings have not been consistently observed. This may be due to small sample sizes and differences in ethnicities. Therefore, we performed a meta‐analysis on the studies that investigated cytokine gene polymorphisms in IBS patients compared to healthy controls.

[1]  S. Ng,et al.  Inflammatory bowel disease in Asia: A systematic review , 2012, Journal of gastroenterology and hepatology.

[2]  N. Rezaei,et al.  Cytokines and irritable bowel syndrome: where do we stand? , 2012, Cytokine.

[3]  W. Shih,et al.  Serum and Colonic Mucosal Immune Markers in Irritable Bowel Syndrome , 2012, The American Journal of Gastroenterology.

[4]  M. Schmulson,et al.  Lower Serum IL-10 Is an Independent Predictor of IBS Among Volunteers in Mexico , 2012, The American Journal of Gastroenterology.

[5]  S. Ng,et al.  Genetics of inflammatory bowel disease in Asia: Systematic review and meta‐analysis , 2011, Inflammatory bowel diseases.

[6]  M. Heitkemper,et al.  Pro‐inflammatory chemokine C‐C motif ligand 16 (CCL‐16) dysregulation in irritable bowel syndrome (IBS): a pilot study , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[7]  I. Roberts-Thomson,et al.  Cells, cytokines and inflammatory bowel disease: a clinical perspective , 2011, Expert review of gastroenterology & hepatology.

[8]  M. Storr,et al.  Prednisolone and budesonide for short- and long-term treatment of microscopic colitis: systematic review and meta-analysis. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[9]  M. Wouters.  New insight in the pathogenesis of functional gastrointestinal disorders: association between genetics and colonic transit , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[10]  M. Surette,et al.  Mesalazine (5‐aminosalicylic acid) alters faecal bacterial profiles, but not mucosal proteolytic activity in diarrhoea‐predominant irritable bowel syndrome , 2011, Alimentary pharmacology & therapeutics.

[11]  P. Enck,et al.  Post-infectious irritable bowel syndrome--a review of the literature. , 2011, Zeitschrift fur Gastroenterologie.

[12]  M. Yang,et al.  A meta-analysis on the association between three promoter variants of TNF-α and Crohn’s disease , 2011, Molecular Biology Reports.

[13]  T. Yao,et al.  Decreased Interleukin-10 Secretion by Peripheral Blood Mononuclear Cells in Children With Irritable Bowel Syndrome , 2011, Journal of pediatric gastroenterology and nutrition.

[14]  U. Ghoshal,et al.  Post‐infectious irritable bowel syndrome: The past, the present and the future , 2011, Journal of gastroenterology and hepatology.

[15]  N. Rezaei,et al.  Lack of Association between Interleukin 12 C(-1188)A Polymorphism and Irritable Bowel Syndrome , 2011, Avicenna journal of medical biotechnology.

[16]  R. Sabat,et al.  Biology of interleukin-10. , 2010, Cytokine & growth factor reviews.

[17]  P. Scully,et al.  Plasma Cytokine Profiles in Females With Irritable Bowel Syndrome and Extra-Intestinal Co-Morbidity , 2010, The American Journal of Gastroenterology.

[18]  T. Dinan,et al.  IBS: an epigenetic perspective , 2010, Nature Reviews Gastroenterology &Hepatology.

[19]  I. Sung,et al.  G protein β3 subunit, interleukin‐10, and tumor necrosis factor‐α gene polymorphisms in Koreans with irritable bowel syndrome , 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[20]  J. Qiu,et al.  Meta‐analysis: polymorphisms in TNF‐α gene promoter and Crohn’s disease , 2010, Alimentary pharmacology & therapeutics.

[21]  J. Ashok Kumar,et al.  Cytokine gene polymorphisms in irritable bowel syndrome in Indian population--a pilot case control study. , 2010, Tropical gastroenterology : official journal of the Digestive Diseases Foundation.

[22]  A. Garg,et al.  Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis. , 2010, Gastroenterology.

[23]  N. Rezaei,et al.  T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome , 2010, Inflammation.

[24]  L. Öhman,et al.  Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions , 2010, Nature Reviews Gastroenterology &Hepatology.

[25]  K. Gwee.  Post-Infectious Irritable Bowel Syndrome, an Inflammation-Immunological Model with Relevance for Other IBS and Functional Dyspepsia , 2010, Journal of neurogastroenterology and motility.

[26]  G. Barbara,et al.  Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof‐of‐concept study , 2009, Alimentary pharmacology & therapeutics.

[27]  L. Öhman,et al.  T-Cell Activation in Patients With Irritable Bowel Syndrome , 2009, The American Journal of Gastroenterology.

[28]  J. Ceuppens,et al.  Immune dysfunction in patients with functional gastrointestinal disorders , 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[29]  P. Scully,et al.  Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses , 2009, Biological Psychiatry.

[30]  M. Boivin,et al.  Mechanism of cytokine modulation of epithelial tight junction barrier. , 2009, Frontiers in bioscience.

[31]  N. Rezaei,et al.  Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome , 2009, Journal of Clinical Immunology.

[32]  Zong-hai Lu,et al.  Effect of the Polymorphism of Tumor Necrosis Factor-α-308 G/A Gene Promoter on the Susceptibility to Ulcerative Colitis: A Meta-Analysis , 2008, Digestion.

[33]  E. Mayer.  Clinical practice. Irritable bowel syndrome. , 2008, The New England journal of medicine.

[34]  T. Dinan,et al.  Mucosal cytokine imbalance in irritable bowel syndrome , 2008, Scandinavian journal of gastroenterology.

[35]  Gerald Holtmann,et al.  Immune activation in patients with irritable bowel syndrome. , 2007, Gastroenterology.

[36]  M. Sata,et al.  Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase , 2006, Mediators of inflammation.

[37]  P. Scully,et al.  Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? , 2006, Gastroenterology.

[38]  B. Connor.  Sequelae of traveler's diarrhea: focus on postinfectious irritable bowel syndrome. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[39]  H. Verspaget,et al.  Role of Tumor Necrosis Factor-α and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome , 2005, The American Journal of Gastroenterology.

[40]  S. Collins,et al.  Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. , 2005, Gastroenterology.

[41]  F. Shanahan,et al.  Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. , 2005, Gastroenterology.

[42]  O. Nielsen,et al.  Involvement of interleukin-4 and -10 in inflammatory bowel disease , 1996, Digestive Diseases and Sciences.

[43]  H. Verspaget,et al.  Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. , 2005, The American journal of gastroenterology.

[44]  G. Holtmann,et al.  Are There Alterations of Neuroendocrine and Cellular Immune Responses to Nutrients in Women with Irritable Bowel Syndrome? , 2004, American Journal of Gastroenterology.

[45]  P. Whorwell,et al.  Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? , 2003, Gut.

[46]  J. Gauldie,et al.  IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[47]  J. Satsangi,et al.  Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. , 2000, Genes and immunity.

[48]  P. Hasleton,et al.  Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. , 1998, Transplantation.

[49]  V. Pravica,et al.  Genotyping for polymorphisms in interferon-γ, interleukin-10, transforming growth factor-β1 and tumour necrosis factor-α genes: a technical report , 1998 .

[50]  V. Pravica,et al.  Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta 1 and tumour necrosis factor-alpha genes: a technical report. , 1998, Transplant immunology.

[51]  M. Suthanthiran.  Clinical application of molecular biology: a study of allograft rejection with polymerase chain reaction. , 1997, The American journal of the medical sciences.

[52]  T. Kucharzik,et al.  Circulating antiinflammatory cytokine IL‐10 in patients with inflammatory bowel disease (IBD) , 1995, Clinical and experimental immunology.

[53]  S. Schreiber,et al.  Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. , 1995, Gastroenterology.

[54]  A. Kulkarni,et al.  Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. , 1993, The American journal of pathology.

[55]  G. Sturniolo,et al.  [Irritable bowel syndrome]. , 1988, Giornale di clinica medica.