A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy

[1]  B. Salehi,et al.  Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits , 2021, Frontiers in Pharmacology.

[2]  B. Salehi,et al.  Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence , 2021, Frontiers in Pharmacology.

[3]  C. Tonelli,et al.  The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action , 2020, Frontiers in Pharmacology.

[4]  D. Calina,et al.  The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies , 2020, Journal of clinical medicine.

[5]  M. Sharifi-Rad,et al.  Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases , 2020, Frontiers in Physiology.

[6]  R. Tulsawani,et al.  Loss of Protection by Antiepileptic Drugs in Lipopolysaccharide-primed Pilocarpine-induced Status Epilepticus is Mediated via Inflammatory Signalling , 2020, Neuroscience.

[7]  M. Sharifi-Rad,et al.  Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds , 2020, International journal of environmental research and public health.

[8]  B. Salehi,et al.  Rosmarinus plants: Key farm concepts towards food applications , 2020, Phytotherapy research : PTR.

[9]  B. Salehi,et al.  Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases , 2020, Journal of clinical medicine.

[10]  D. Calina,et al.  Cannabinoids in the Pathophysiology of Skin Inflammation , 2020, Molecules.

[11]  B. Salehi,et al.  Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited , 2020, Biomolecules.

[12]  PRELIMINARY SCREENING OF A CLASSICAL UNANI FORMULATION MAJOON NAJAH FOR ANTICONVULSANT ACTIVITY , 2019, International Journal of Pharmaceutical Research.

[13]  J. Sharifi‐Rad,et al.  A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse , 2019, Journal of clinical medicine.

[14]  P. Iwanowski,et al.  Advances in the Potential Biomarkers of Epilepsy , 2019, Front. Neurol..

[15]  R. Macdonald,et al.  A structural look at GABAA receptor mutations linked to epilepsy syndromes , 2019, Brain Research.

[16]  Tyler Bahr,et al.  The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review , 2019, Evidence-based complementary and alternative medicine : eCAM.

[17]  Dong Woon Kim,et al.  Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy , 2019, Advances in nutrition.

[18]  Z. Selamoğlu,et al.  Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential , 2019, Molecules.

[19]  B. Salehi,et al.  Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties , 2019, Biomolecules.

[20]  L. Borgelt,et al.  Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes , 2019, The Annals of pharmacotherapy.

[21]  Jasenko Zivanov,et al.  GABAA receptor signalling mechanisms revealed by structural pharmacology , 2019, Nature.

[22]  O. Devinsky,et al.  Long‐term cannabidiol treatment in patients with Dravet syndrome: An open‐label extension trial , 2018, Epilepsia.

[23]  A. Satish,et al.  EVALUATION OF THE ANTICONVULSANT ACTIVITY OF ETHANOL EXTRACT OF PSIDIUM GUAJAVA (GUAVA LEAVES) IN ALBINO MICE , 2019 .

[24]  B. Salehi,et al.  Epibatidine: A Promising Natural Alkaloid in Health , 2018, Biomolecules.

[25]  A. Zaitsev,et al.  Seizure-Induced Potentiation of AMPA Receptor-Mediated Synaptic Transmission in the Entorhinal Cortex , 2018, Front. Cell. Neurosci..

[26]  Seda Savranoglu Kulabas,et al.  Ameliorative potential of Lavandula stoechas in metabolic syndrome via multitarget interactions. , 2018, Journal of ethnopharmacology.

[27]  Anup D. Patel,et al.  Long‐term safety and treatment effects of cannabidiol in children and adults with treatment‐resistant epilepsies: Expanded access program results , 2018, Epilepsia.

[28]  A. Mukherjee,et al.  Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress , 2018 .

[29]  B. Salehi,et al.  Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. , 2018, Microbiological research.

[30]  Anup D. Patel,et al.  Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome , 2018, The New England journal of medicine.

[31]  I. Scheffer,et al.  Epilepsy , 2018, Nature Reviews Disease Primers.

[32]  Eric Marsh,et al.  Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial , 2018, The Lancet.

[33]  A. Asadi-Pooya.  Lennox-Gastaut syndrome: a comprehensive review , 2018, Neurological Sciences.

[34]  R. Khan,et al.  Anticonvulsant Effects of Trigonella foenum-Graecum L. in Strychnine Induced Epilepsy Model , 2017 .

[35]  D. Friedman,et al.  Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open‐label clinical study with cannabidiol , 2017, Epilepsia.

[36]  Dinesh Y. Gawande,et al.  Anticonvulsant activity and acute neurotoxic profile of Achyranthes aspera Linn. , 2017, Journal of ethnopharmacology.

[37]  Tongtong Ge,et al.  The effects of herbal medicine on epilepsy , 2017, Oncotarget.

[38]  E. Wirrell,et al.  Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel. , 2017, Pediatric neurology.

[39]  K. Lundstrom,et al.  Interaction of Plant Extracts with Central Nervous System Receptors , 2017, Medicines.

[40]  A. Bhandari,et al.  Antiepileptic activity of Murraya Koenigii Leaf Extracts , 2016 .

[41]  S. Nabavi,et al.  Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases , 2016, Pharmacological reports : PR.

[42]  Peng Li,et al.  Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo , 2016, Front. Pharmacol..

[43]  P. Mazumder,et al.  Antiepileptic Activity of Methanol Extract of Butea monosperma (Lam.)Kuntze and its Isoalted Bioactive Compound in Experimentally InducedConvulsion in Swiss Albino Mice , 2016 .

[44]  M. Carles,et al.  A pharmacological basis of herbal medicines for epilepsy , 2015, Epilepsy & Behavior.

[45]  C. Bladen,et al.  Anticonvulsant mechanisms of piperine, a piperidine alkaloid , 2015, Channels.

[46]  A. Becker,et al.  Methanol extract of Ficus platyphylla ameliorates seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice. , 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[47]  R. M. de Freitas,et al.  The Role of Flavonoids on Oxidative Stress in Epilepsy , 2015, Oxidative medicine and cellular longevity.

[48]  Ji-min Cao,et al.  Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming α subunit , 2014, Acta Pharmacologica Sinica.

[49]  R. Ramani,et al.  Antiepileptic activity of leaves of Leucas aspera. , 2014 .

[50]  Surajit Banerjee,et al.  X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors , 2014, Nature.

[51]  A. Becker,et al.  The anxiolytic effects of a Valerian extract is based on Valerenic acid , 2014, BMC Complementary and Alternative Medicine.

[52]  Benjamin J. Whalley,et al.  Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders , 2014, Epilepsia.

[53]  T. Snutch,et al.  Low threshold T‐type calcium channels as targets for novel epilepsy treatments , 2014, British journal of clinical pharmacology.

[54]  J. H. Cross,et al.  ILAE Official Report: A practical clinical definition of epilepsy , 2014, Epilepsia.

[55]  R. Verpoorte,et al.  What is in a name? The need for accurate scientific nomenclature for plants. , 2014, Journal of ethnopharmacology.

[56]  T. Heinbockel,et al.  Identification of both GABAA receptors and voltage-activated Na+ channels as molecular targets of anticonvulsant α-asarone , 2014, Front. Pharmacol..

[57]  N. Mirazi,et al.  Acute administration of ginger (Zingiber officinale rhizomes) extract on timed intravenous pentylenetetrazol infusion seizure model in mice , 2014, Epilepsy Research.

[58]  O. Kudlacek,et al.  Mechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[59]  P. Forgó,et al.  Diterpene Alkaloids from the Roots of Aconitum moldavicum and Assessment of Nav 1.2 Sodium Channel Activity of Aconitum Alkaloids , 2014, Planta Medica.

[60]  Peng Li,et al.  Medicinal compounds with antiepileptic/anticonvulsant activities , 2014, Epilepsia.

[61]  Walter Sandtner,et al.  Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile☆ , 2013, Toxicology and applied pharmacology.

[62]  W. Luyten,et al.  Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. , 2013, ACS chemical neuroscience.

[63]  R. Mohanraj,et al.  VGKC complex antibodies in epilepsy: Diagnostic yield and therapeutic implications , 2013, Seizure.

[64]  P. Forgó,et al.  Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids. , 2013, Fitoterapia.

[65]  Yan-wen Shu,et al.  Curcumin Serves as a Human Kv1.3 Blocker to Inhibit Effector Memory T Lymphocyte Activities , 2013, Phytotherapy research : PTR.

[66]  C. Schwarzer,et al.  GABAA receptor modulation by piperine and a non-TRPV1 activating derivative☆ , 2013, Biochemical pharmacology.

[67]  A. Kimbaris,et al.  Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration , 2013, Epilepsy research and treatment.

[68]  Cheng-Wei Lu,et al.  Tanshinone IIA, a constituent of Danshen, inhibits the release of glutamate in rat cerebrocortical nerve terminals. , 2013, Journal of ethnopharmacology.

[69]  F. Scorza,et al.  Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms , 2013, Pharmacology Biochemistry and Behavior.

[70]  A. Mandegary,et al.  Anticonvulsant Activity and Toxicity of Essential Oil and Methanolic Extract of Zhumeria majdae Rech, a Unique Iranian Plant in Mice , 2012, Neurochemical Research.

[71]  Marjan Nassiri-Asl,et al.  Neuroprotective Effects of Vitexin, a Flavonoid, on Pentylenetetrazole‐Induced Seizure in Rats , 2012, Chemical biology & drug design.

[72]  A. Gorji,et al.  Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain , 2012, BMC Complementary and Alternative Medicine.

[73]  Mahfoozur Rahman,et al.  Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats. , 2012, Journal of ethnopharmacology.

[74]  Shao-qun Luan,et al.  Effects of epigallocatechin-3-gallate on pentylenetetrazole-induced kindling, cognitive impairment and oxidative stress in rats , 2012, Neuroscience Letters.

[75]  H. Fachim,et al.  Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: Evaluating its anticonvulsant and anxiolytic potential , 2012, Epilepsy & Behavior.

[76]  A. Asadi-Pooya,et al.  Old Remedies for Epilepsy: Avicenna’s Medicine , 2012, Iranian Red Crescent medical journal.

[77]  Damanpreet Singh,et al.  Dual protective effect of Passiflora incarnata in epilepsy and associated post-ictal depression. , 2012, Journal of ethnopharmacology.

[78]  P. Sharma,et al.  Antiepileptic activity of aqueous extract of Tricosanthes dioica Roxb . , 2012 .

[79]  G. Gupta,et al.  Anticonvulsant and depressant-like activity of ursolic acid stearoyl glucoside isolated from Lantana camara L. (verbanaceae) , 2012 .

[80]  Sheng-Nan Wu,et al.  Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability , 2012, Psychopharmacology.

[81]  S. Schachter,et al.  The NMDA receptor complex as a therapeutic target in epilepsy: a review , 2011, Epilepsy & Behavior.

[82]  A. Rakotonirina,et al.  Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy , 2011 .

[83]  D. Kang,et al.  Baicalein and wogonin are activators of rat TREK‐2 two‐pore domain K+ channel , 2011, Acta physiologica.

[84]  J. Hanrahan,et al.  Flavonoid modulation of GABAA receptors , 2011, British journal of pharmacology.

[85]  S. Schachter.  Botanicals and herbs: A traditional approach to treating epilepsy , 2009, Neurotherapeutics.

[86]  A. Jalsrai,et al.  Evaluation of the effects of Astragalus mongholicus Bunge saponin extract on central nervous system functions. , 2010, Journal of ethnopharmacology.

[87]  D. Rossi,et al.  Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. , 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[88]  R. Almeida,et al.  Carvacrol, (-)-Borneol and citral reduce convulsant activity in rodents. , 2010 .

[89]  P. Bhutada,et al.  Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice , 2010, Epilepsy & Behavior.

[90]  Marjan Nassiri-Asl,et al.  The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats , 2010, Epilepsy & Behavior.

[91]  Arijit Basu,et al.  Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. , 2010, Journal of ethnopharmacology.

[92]  Benjamin J. Whalley,et al.  Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo , 2010, Journal of Pharmacology and Experimental Therapeutics.

[93]  Zhuo Yang,et al.  Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage‐dependent sodium channels in hippocampal CA1 pyramidal neurons , 2010, Phytotherapy research : PTR.

[94]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.

[95]  Barbara Bloom,et al.  Costs of complementary and alternative medicine (CAM) and frequency of visits to CAM practitioners: United States, 2007. , 2009, National health statistics reports.

[96]  A. Hartman,et al.  The ketogenic diet: Uses in epilepsy and other neurologic illnesses , 2008, Current treatment options in neurology.

[97]  S. Schachter.  Complementary and alternative medical therapies , 2008, Current opinion in neurology.

[98]  Byung-Hwan Lee,et al.  Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes. , 2006, Molecules and cells.

[99]  M. Moshi,et al.  Plants used to treat epilepsy by Tanzanian traditional healers. , 2005, Journal of ethnopharmacology.

[100]  G. Sperk,et al.  Anticonvulsant and Antiepileptogenic Effects Mediated by Adeno-Associated Virus Vector Neuropeptide Y Expression in the Rat Hippocampus , 2004, The Journal of Neuroscience.

[101]  M. Leal,et al.  Long-Lasting Ibogaine Protection against NMDA-Induced Convulsions in Mice , 2000, Neurochemical Research.

[102]  P. Cooper,et al.  Ketogenic diet for epilepsy. , 2003, The Cochrane database of systematic reviews.

[103]  Xinmin Li,et al.  Clinical observation on 930 child epilepsy cases treated with anti-epilepsy capsules. , 2003, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[104]  H. Chiang,et al.  Stimulation of the BKCa channel in cultured smooth muscle cells of human trachea by magnolol , 2002, Thorax.

[105]  A. Gorji,et al.  History of epilepsy in Medieval Iranian medicine , 2001, Neuroscience & Biobehavioral Reviews.

[106]  J. Elferink.  Epilepsy and Its Treatment in the Ancient Cultures of America , 1999, Epilepsia.

[107]  W. Matuja,et al.  Knowledge, attitude and practice (KAP) towards epilepsy in secondary school students in Tanzania. , 1994, The Central African journal of medicine.

[108]  B. Manyam.  Epilepsy in Ancient India , 1992, Epilepsia.

[109]  C. Lai,et al.  History of Epilepsy in Chinese Traditional Medicine , 1991, Epilepsia.

[110]  A. Sacaan,et al.  Anticonvulsant Effects of Some Arab Medicinal Plants , 1987 .

[111]  Valverde Jl.  The aztec herbal of 1552. Martín de la Cruz' "Libellus de medicinalibus indorum herbis"; context of the sources on nahualt materia medica. , 1984 .

[112]  J. Valverde.  The aztec herbal of 1552. Martín de la Cruz' "Libellus de medicinalibus indorum herbis"; context of the sources on nahualt materia medica. , 1984, Veroffentlichungen der Internationalen Gesellschaft fur Geschichte der Pharmazie e. V.

[113]  K. Mattock,et al.  Chinese medicine. , 1976, The Australasian nurses journal.

[114]  M. G. Peterman,et al.  Ketogenic Diet for Epilepsy , 2008 .