Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients

Patients with frontal lobe lesions, amnesic patients with Korsakoff's syndrome, other (non-Korsakoff) amnesic patients, and control subjects were given tests of memory for temporal order. In the first experiment, subjects were presented with a list of 15 words and then asked to reproduce the list order from a random array of the words. In the second experiment, they were asked to arrange in chronological order a random display of 15 factual events that occurred between 1941 and 1985. In both experiments, patients with frontal lobe lesions were impaired in placing the items in the correct temporal order, despite normal item memory (i.e. normal recall and recognition memory for the words and facts). The two groups of amnesic patients exhibited impaired memory for temporal order as well as impaired item memory. Patients with Korsakoff's syndrome exhibited poorer temporal order memory than the other amnesic patients, despite similar levels of item memory. These findings demonstrate that patients with frontal lobe lesions have difficulty organizing information temporally. Patients with Korsakoff's syndrome, who have both diencephalic and frontal damage, have memory impairment together with a disproportionate deficit in memory for temporal order.

[1]  R. Church,et al.  Attention and the frontal cortex as examined by simultaneous temporal processing , 1988, Neuropsychologia.

[2]  D. Neary,et al.  Long term memory for famous voices in amnesic and normal subjects , 1980, Neuropsychologia.

[3]  Antonio Incisa della Rocchetta,et al.  Classification and Recall of Pictures After Unilateral Frontal or Temporal Lobectomy , 1986, Cortex.

[4]  Felicia A. Huppert,et al.  Recognition Memory in Amnesic Patients: Effect of Temporal Context and Familiarity of Material , 1976, Cortex.

[5]  Raymond P. Kesner,et al.  Dissociation of item and order spatial memory in rats following medial prefrontal cortex lesions , 1987, Neuropsychologia.

[6]  L Weiskrantz,et al.  Neuroanatomy of memory and amnesia: a case for multiple memory systems. , 1987, Human neurobiology.

[7]  Daniel L. Schacter,et al.  Retrieval without Recollection: An Experimental Analysis of Source Amnesia , 1984 .

[8]  Arthur P. Shimamura,et al.  Memory and metamemory: Comparisons between patients with frontal lobe lesions and amnesic patients , 1989, Psychobiology.

[9]  B. Milner,et al.  Frontal lobes and the temporal organization of memory. , 1985, Human neurobiology.

[10]  A P Shimamura,et al.  Cognitive impairment following frontal lobe damage and its relevance to human amnesia. , 1989, Behavioral neuroscience.

[11]  A. Mayes,et al.  Human organic memory disorders , 1988 .

[12]  C. Reynolds,et al.  Wechsler memory scale-revised , 1988 .

[13]  Tim Shallice,et al.  The Involvement of the Frontal Lobes in Cognitive Estimation , 1978, Cortex.

[14]  E. Tulving.  Elements of episodic memory , 1983 .

[15]  L R Squire,et al.  A neuropsychological study of fact memory and source amnesia. , 1987, Journal of experimental psychology. Learning, memory, and cognition.

[16]  Brenda Milner,et al.  Differential effects of frontal-lobe lesions on cognitive estimation and spatial memory , 1984, Neuropsychologia.

[17]  R. Lazar,et al.  Effects of frontal lobe lesions on hypothesis sampling during concept formation , 1983, Neuropsychologia.

[18]  Benton J. Underwood,et al.  Temporal Codes for Memories: Issues and Problems , 1976 .

[19]  D. Schacter.  Memory, amnesia, and frontal lobe dysfunction , 1987, Psychobiology.

[20]  W. Lishman,et al.  Selective memory loss and global intellectual deficits in alcoholic Korsakoff's syndrome , 1987, Psychological Medicine.

[21]  P. R. Meudell,et al.  Regency and Frequency Judgements in Alcoholic Amnesics and Normal People with Poor Memory , 1985, Cortex.

[22]  E. Tulving,et al.  Episodic and semantic memory , 1972 .

[23]  D. Amaral,et al.  Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging , 1989, Nature.

[24]  L. Squire,et al.  Cognitive impairment following frontal lobe damage and its relevance to human amnesia. , 1989 .

[25]  Arthur P. Shimamura,et al.  The neurology of memory: quantitative assessment of retrograde amnesia in two groups of amnesic patients , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[26]  A. Pickering,et al.  Is Organic Amnesia Caused by a Selective Deficit in Remembering Contextual Information? , 1985, Cortex.

[27]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[28]  L. Squire,et al.  Korsakoff's syndrome: radiological (CT) findings and neuropsychological correlates , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[29]  E. A. Berg,et al.  A simple objective technique for measuring flexibility in thinking. , 1948, The Journal of general psychology.

[30]  Characterizing amnesic patients for neurobehavioral study. , 1986 .

[31]  Bruce T Volpe,et al.  Temporal order judgments with amnesia , 1982, Brain and Cognition.

[32]  L. Squire,et al.  Characterizing amnesic patients for neurobehavioral study. , 1986, Behavioral neuroscience.

[33]  Arthur P. Shimamura,et al.  Source memory impairment in patients with frontal lobe lesions , 1989, Neuropsychologia.

[34]  A. Luria.  Higher Cortical Functions in Man , 1980, Springer US.

[35]  H. Kucera,et al.  Computational analysis of present-day American English , 1967 .

[36]  L. Squire.  Comparisons between forms of amnesia: some deficits are unique to Korsakoff's syndrome. , 1982, Journal of experimental psychology. Learning, memory, and cognition.

[37]  L. Squire.  CHAPTER 7 – Memory and the Brain* , 1986 .

[38]  N Butters,et al.  Short-term visual and auditory memory disorders after parietal and frontal lobe damage. , 1970, Cortex; a journal devoted to the study of the nervous system and behavior.

[39]  L R Squire,et al.  Memory and metamemory: a study of the feeling-of-knowing phenomenon in amnesic patients. , 1986, Journal of experimental psychology. Learning, memory, and cognition.

[40]  K. Poeck,et al.  The influence of stretched speech presentation on token test performance of aphasic and right brain damaged patients , 1981, Neuropsychologia.

[41]  R. B. Freeman,et al.  A Verbal Long Term Memory Deficit in Frontal Lobe Damaged Patients , 1986, Cortex.