Permanent Cardiac Replacement by A Total Artificial Heart: Experimental Background and Current Problems

I could not be more delighted. Nearly 13 years after the implantation of an artificial heart into Dr Barney Clark in 1982, the Utah-type artificial heart (first called the Jarvik heart, then the Symbion heart, and now the CardioWest heart) has returned to Utah. On 12 April 1995 James W. Long implanted this artificial heart in Alvin Marsden at the LDS Hospital in Salt Lake City. It was my privilege to visit with him 10 days later.

[1]  L Smith,et al.  Development on the implantation of a total nuclear-powered artificial heart system. , 1974, Transactions - American Society for Artificial Internal Organs.

[2]  W. Kolff,et al.  The intracorporeal mechanical heart. , 1966, Vascular diseases.

[3]  J. Copeland,et al.  Thromboembolic complications of the Jarvik-7 total artificial heart: case report. , 1986, Artificial organs.

[4]  S. W. Kim Platelet adhesion and prevention at blood-polymer interface. , 1987, Artificial organs.

[5]  D B Olsen,et al.  Prototype Continuous Flow Ventricular Assist Device Supported on Magnetic Bearings. , 1996, Artificial organs.

[6]  A. Gristina,et al.  Biomaterial-centered infection: microbial adhesion versus tissue integration. , 1987, Science.

[7]  S. W. Kim,et al.  Heparinized polyurethanes: in vitro and in vivo studies. , 1985, Journal of biomedical materials research.

[8]  Y. Kim,et al.  In vitro studies of immobilized heparin and sulfonated polyurethane using epifluorescent video microscopy. , 1995, ASAIO journal (1992).

[9]  Teruo Okano,et al.  PGE1-Heparin conjugate releasing polymers , 1985 .

[10]  H P Heimes,et al.  Completely Integrated Wearable TAH-drive Unit , 1982, The International journal of artificial organs.

[11]  O. Frazier,et al.  The Orthotopic Univentricular Artificial Heart , 1989 .

[12]  D B Olsen,et al.  The artificial heart in human subjects. , 1984, Journal of Thoracic and Cardiovascular Surgery.

[13]  T. Akutsu,et al.  Results obtained with artificial hearts driven by the N.A.S.A. servomechanism and the pathologic physiology of artificial hearts. , 1962, Transactions - American Society for Artificial Internal Organs.

[14]  A. Paccagnella,et al.  Properties of a new carbon film for biomedical applications. , 1986, The International journal of artificial organs.

[15]  W. Kolff,et al.  AN ELECTRONIC-MECHANICAL CONTROL FOR AN INTRATHORACIC ARTIFICIAL HEART. , 1963, The American journal of medical electronics.

[16]  T. Akutsu,et al.  ARTIFICIAL HEART WITH ANTI-VACUUM BELLOWS , 1962 .

[17]  W. Kolff,et al.  A prosthetic heart with hemispherical ventricles designed for low hemolytic action. , 1970, Transactions - American Society for Artificial Internal Organs.

[18]  T. Akutsu,et al.  Pendulum type of artificial heart within the chest: preliminiary report. , 1960, American heart journal.

[19]  A R Jonsen,et al.  Artificial heart and assist devices: directions, needs, costs, societal and ethical issues. , 1985, Artificial organs.

[20]  W J Kolff,et al.  The tenth Hastings lecture. Experiences and practical considerations for the future of artificial hearts and of mankind. , 2008, Artificial organs.

[21]  P Litwak,et al.  In vivo evaluations of a new thromboresistant polyurethane for artificial heart blood pumps. , 1988, The Journal of thoracic and cardiovascular surgery.

[22]  T. Akutsu,et al.  A SPECIAL RECIPROCATING PUMP TO DRIVE AN ARTIFICIAL HEART INSIDE THE CHEST. , 1964, The Journal of thoracic and cardiovascular surgery.

[23]  D B Olsen,et al.  In vitro development of automatic control for the actively filled electrohydraulic heart. , 1988, Artificial organs.

[24]  R. Pichel,et al.  A cardiac output monitor and diagnostic unit for pneumatically driven artificial hearts. , 1984, Artificial organs.

[25]  W. Kolff The artificial heart: research, development or invention? , 1969, Diseases of the chest.

[26]  D B Olsen,et al.  Response of the human body to the first permanent implant of the Jarvik-7 Total Artificial Heart. , 1983, Transactions - American Society for Artificial Internal Organs.