Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins

[1]  F. Quiocho,et al.  PI-SCEI, A HOMING ENDONUCLEASE WITH PROTEIN SPLICING ACTIVITY , 1998 .

[2]  S. Pietrokovski,et al.  Modular organization of inteins and C‐terminal autocatalytic domains , 1998, Protein science : a publication of the Protein Society.

[3]  Thomas L. Madden,et al.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. , 1997, Nucleic acids research.

[4]  F. Quiocho,et al.  Crystal Structure of PI-SceI, a Homing Endonuclease with Protein Splicing Activity , 1997, Cell.

[5]  G J Olsen,et al.  Compilation and analysis of intein sequences. , 1997, Nucleic acids research.

[6]  P. Beachy,et al.  Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development , 1996, Science.

[7]  F. Perler,et al.  The mechanism of protein splicing and its modulation by mutation. , 1996, The EMBO journal.

[8]  T. Bürglin,et al.  Warthog and Groundhog, novel families related to Hedgehog , 1996, Current Biology.

[9]  Eugene V Koonin,et al.  Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain , 1996, Cell.

[10]  A G Murzin,et al.  Structural classification of proteins: new superfamilies. , 1996, Current opinion in structural biology.

[11]  G. Chang,et al.  Crystal Structure of the Lactose Operon Repressor and Its Complexes with DNA and Inducer , 1996, Science.

[12]  J. Thornton,et al.  PROMOTIF—A program to identify and analyze structural motifs in proteins , 1996, Protein science : a publication of the Protein Society.

[13]  Jack Benner,et al.  Activation of Glycosylasparaginase , 1996, The Journal of Biological Chemistry.

[14]  D Eisenberg,et al.  3D domain swapping: A mechanism for oligomer assembly , 1995, Protein science : a publication of the Protein Society.

[15]  A. Murzin,et al.  A protein catalytic framework with an N-terminal nucleophile is capable of self-activation , 1995, Nature.

[16]  U Heinemann,et al.  Circular permutations of protein sequence: not so rare? , 1995, Trends in biochemical sciences.

[17]  J. J. Lee,et al.  Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. , 1995, Development.

[18]  R. Moon,et al.  Patterning activities of vertebrate hedgehog proteins in the developing eye and brain , 1995, Current Biology.

[19]  R. Moon,et al.  Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. , 1995, Development.

[20]  P. Beachy,et al.  Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage , 1995, Current Biology.

[21]  Marc Tessier-Lavigne,et al.  Induction of midbrain dopaminergic neurons by Sonic hedgehog , 1995, Neuron.

[22]  A. Taylor,et al.  Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila , 1995, Current Biology.

[23]  A. McMahon,et al.  Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants , 1995, Nature.

[24]  T. Jessell,et al.  Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis , 1995, Cell.

[25]  M. Tessier-Lavigne,et al.  Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway , 1995, Cell.

[26]  R B Russell,et al.  Swaposins: circular permutations within genes encoding saposin homologues. , 1995, Trends in biochemical sciences.

[27]  A. McMahon,et al.  Proteolytic processing yields two secreted forms of sonic hedgehog , 1995, Molecular and cellular biology.

[28]  E V Koonin,et al.  A protein splice-junction motif in hedgehog family proteins. , 1995, Trends in biochemical sciences.

[29]  Stephen C. Ekker,et al.  The product of hedgehog autoproteolytic cleavage active in local and long-range signalling , 1995, Nature.

[30]  J. J. Lee,et al.  Autoproteolysis in hedgehog protein biogenesis. , 1994, Science.

[31]  S. Pietrokovski,et al.  Conserved sequence features of inteins (protein introns) and their use in identifying new inteins and related proteins , 1994, Protein science : a publication of the Protein Society.

[32]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[33]  M. Schumacher,et al.  Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. , 1994, Science.

[34]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[35]  H. Erickson,et al.  Crystallization of a fragment of human fibronectin: Introduction of methionine by site‐directed mutagenesis to allow phasing via selenomethionine , 1994, Proteins.

[36]  N. Neff,et al.  Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature. , 1994, Nucleic acids research.

[37]  S. Winistorfer,et al.  Recombinant circle PCR and recombination PCR for site-specific mutagenesis without PCR product purification. , 1992, BioTechniques.

[38]  W. Hendrickson Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. , 1991, Science.

[39]  P. Kraulis A program to produce both detailed and schematic plots of protein structures , 1991 .

[40]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[41]  G D Schuler,et al.  A workbench for multiple alignment construction and analysis , 1991, Proteins.

[42]  D. Moras,et al.  Cardiotoxin VII4 from Naja mossambica mossambica. The refined crystal structure. , 1990, Journal of molecular biology.

[43]  W A Hendrickson,et al.  Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three‐dimensional structure. , 1990, The EMBO journal.

[44]  R M Stroud,et al.  The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor. , 1986, Protein engineering.

[45]  A Wlodawer,et al.  Crystallization of nerve growth factor from mouse submaxillary glands. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Z. Otwinowski,et al.  Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[47]  A. McMahon,et al.  The world according to hedgehog. , 1997, Trends in genetics : TIG.

[48]  I. Saira Mian,et al.  Statistic Modeling, Phylogenetic Analysis and Strjucture Prediction of a Protein Splicing Domain Common to Infeins and Hedgehog Proteins , 1997, J. Comput. Biol..

[49]  Andrew P. McMahon,et al.  The world according to bedgebog , 1997 .

[50]  V. Biou,et al.  [31] Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement. , 1997, Methods in enzymology.

[51]  S F Altschul,et al.  Local alignment statistics. , 1996, Methods in enzymology.

[52]  Axel T. Brunger,et al.  X-PLOR Version 3.1: A System for X-ray Crystallography and NMR , 1992 .

[53]  W. Wooster,et al.  Crystal structure of , 2005 .