Correlation Trait Loci (CTL) mapping: phenotype network inference subject to genotype

CTL mapping is complementary to the proven quantitative trait locus (QTL) mapping method which maps/associates each separately observed phenotype against genotype. CTL mapping, in contrast, associates correlation differences observed between two phenotypes at a time, subject to the genotype. In other words, QTL mapping treats phenotypes independently while CTL mapping connects phenotypes. CTL show very similar profiles to QTL, but get interesting when they differ (see figure 1).