Ghrelin: Central Actions and Potential Implications in Neurodegenerative Diseases

[1]  M. Traebert,et al.  Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus , 2003, Neuroscience Letters.

[2]  Michael Esterman,et al.  The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis , 2003, Neuron.

[3]  Noboru Murakami,et al.  The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. , 2002, Gastroenterology.

[4]  D. Galimberti,et al.  Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. , 2002, The Journal of endocrinology.

[5]  S. Whitebread,et al.  Ghrelin Acts on Leptin‐Responsive Neurones in the Rat Arcuate Nucleus , 2002, Journal of neuroendocrinology.

[6]  Y. Taché,et al.  Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus , 2002, Neuroscience Letters.

[7]  E. Dellinger,et al.  Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. , 2002, The New England journal of medicine.

[8]  G. Frost,et al.  Ghrelin enhances appetite and increases food intake in humans. , 2001, The Journal of clinical endocrinology and metabolism.

[9]  R. Batterham,et al.  Ghrelin causes hyperphagia and obesity in rats. , 2001, Diabetes.

[10]  K. Moriyama,et al.  A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. , 2001, The Journal of clinical endocrinology and metabolism.

[11]  C. Bowers Unnatural growth hormone-releasing peptide begets natural ghrelin. , 2001, The Journal of clinical endocrinology and metabolism.

[12]  M. Nakazato,et al.  Ghrelin acts in the central nervous system to stimulate gastric acid secretion. , 2001, Biochemical and biophysical research communications.

[13]  M. Nakazato,et al.  A role for ghrelin in the central regulation of feeding , 2001, Nature.

[14]  F. Casanueva,et al.  Ghrelin-induced growth hormone secretion in humans. , 2000, European journal of endocrinology.

[15]  S. Dickson,et al.  Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats , 2000, Journal of neuroendocrinology.

[16]  S. Bloom,et al.  The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. , 2000, Endocrinology.

[17]  A. Pomés,et al.  Adenosine: A partial agonist of the growth hormone secretagogue receptor. , 2000, Biochemical and biophysical research communications.

[18]  L. Thim,et al.  Adenosine is an agonist of the growth hormone secretagogue receptor. , 2000, Endocrinology.

[19]  Dickson,et al.  Growth Hormone Secretagogue Activation of the Arcuate Nucleus and Brainstem Occurs Via a Non‐Noradrenergic Pathway , 2000, Journal of neuroendocrinology.

[20]  M. Nakazato,et al.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach , 1999, Nature.

[21]  J. Rømer,et al.  Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat , 1999, Neuroendocrinology.

[22]  T. McDonald,et al.  Administration of a nonpeptidyl growth hormone secretagogue, L-163, 255, changes somatostatin pattern, but has no effect on patterns of growth hormone-releasing factor in the hypophyseal-portal circulation of the conscious pig. , 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[23]  M. Korbonits,et al.  The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. , 1999, The Journal of clinical endocrinology and metabolism.

[24]  Navarra,et al.  The Effect of Growth Hormone Secretagogues and Neuropeptide Y on Hypothalamic Hormone Release from Acute Rat Hypothalamic Explants , 1999, Journal of neuroendocrinology.

[25]  Roy G. Smith,et al.  A New Orphan Receptor Involved in Pulsatile Growth Hormone Release , 1999, Trends in Endocrinology & Metabolism.

[26]  G. Leng,et al.  An electrophysiological and morphological investigation of the projections of growth hormone-releasing peptide-6-responsive neurons in the rat arcuate nucleus to the median eminence and to the paraventricular nucleus , 1999, Neuroscience.

[27]  L. Lönn,et al.  Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. , 1998, The Journal of clinical endocrinology and metabolism.

[28]  Smith,et al.  The Nonpeptide Growth Hormone Secretagogue, MK‐0677, Activates Hypothalamic Arcuate Nucleus Neurons in vivo , 1998, Journal of neuroendocrinology.

[29]  Roy G. Smith,et al.  Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. , 1997, Molecular endocrinology.

[30]  Roy G. Smith,et al.  Peptidomimetic regulation of growth hormone secretion. , 1997, Endocrine reviews.

[31]  Roy G. Smith,et al.  Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. , 1997, Brain research. Molecular brain research.

[32]  A. Steiger,et al.  Somatostatin Impairs Sleep in Elderly Human Subjects , 1997, Neuropsychopharmacology.

[33]  H. Tamura,et al.  Microinjection of rat GH but not human IGF-I into a defined area of the hypothalamus inhibits endogenous GH secretion in rats. , 1997, The Journal of endocrinology.

[34]  M. Phillips,et al.  Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. , 1997, Molecular endocrinology.

[35]  S. Dickson,et al.  Printed in U.S.A. Copyright © 1997 by The Endocrine Society Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH , 2022 .

[36]  J. Herman,et al.  Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis , 1997, Trends in Neurosciences.

[37]  E. Pellegrini,et al.  Central Administration of a Growth Hormone (GH) Receptor mRNA Antisense Increases GH Pulsatility and Decreases Hypothalamic Somatostatin Expression in Rats , 1996, The Journal of Neuroscience.

[38]  E. van Cauter,et al.  Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. , 1996, The Journal of clinical endocrinology and metabolism.

[39]  R. Dyball,et al.  Retrogradely labelled neurosecretory neurones of the rat hypothalamic arcuate nucleus express Fos protein following systemic injection of GH-releasing peptide-6. , 1996, The Journal of endocrinology.

[40]  S. Ishii,et al.  Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. , 1996, Endocrinology.

[41]  J. Bains,et al.  Electrophysiology of the Circumventricular Organs , 1996, Frontiers in Neuroendocrinology.

[42]  Patrick R. Griffin,et al.  A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release , 1996, Science.

[43]  M. Thorner,et al.  Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults--a clinical research center study. , 1996, The Journal of clinical endocrinology and metabolism.

[44]  J. Kamegai,et al.  Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats. , 1996, Endocrinology.

[45]  I. Clarke,et al.  Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6. , 1996, Domestic animal endocrinology.

[46]  R. Steiner,et al.  Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat. , 1996, Endocrinology.

[47]  E. Vizi,et al.  Hypothalamic α2A-adrenoceptors stimulate growth hormone release in the rat , 1995 .

[48]  M. Herkenham,et al.  Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat , 1995, The Journal of comparative neurology.

[49]  D. Johnston,et al.  Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[50]  G. Leng,et al.  Involvement of the noradrenergic afferents from the nucleus tractus solitarii to the supraoptic nucleus in oxytocin release after peripheral cholecystokinin octapeptide in the rat , 1995, Neuroscience.

[51]  C. Bowers,et al.  Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats. , 1995, Life sciences.

[52]  J. Kamegai,et al.  Growth hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats. , 1994, Endocrinology.

[53]  Alan D. Miller,et al.  The Area Postrema and Vomiting , 1994, Frontiers in Neuroendocrinology.

[54]  V. Lenaerts,et al.  Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. , 1994, Endocrinology.

[55]  G. Dockray,et al.  The G. W. Harris Prize Lecture. The gut endocrine system and its control , 1994, Experimental physiology.

[56]  J. W. Rudy,et al.  DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning. , 1994, Behavioral neuroscience.

[57]  S. Pong,et al.  A nonpeptidyl growth hormone secretagogue. , 1993, Science.

[58]  P. Gross,et al.  Sensory circumventricular organs and brain homeostatic pathways , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[59]  M. Thorner,et al.  Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. , 1993, The Journal of clinical endocrinology and metabolism.

[60]  I. Robinson,et al.  Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons , 1993, Neuroscience.

[61]  J. Kamegai,et al.  Systemic administration of recombinant human growth hormone induces expression of the c-fos gene in the hypothalamic arcuate and periventricular nuclei in hypophysectomized rats. , 1992, Endocrinology.

[62]  I. Merchenthaler,et al.  Neurons with access to the general circulation in the central nervous system of the rat: A retrograde tracing study with fluoro-gold , 1991, Neuroscience.

[63]  T. Day,et al.  Direct catecholaminergic projection from nucleus tractus solitarii to supraoptic nucleus , 1988, Brain Research.

[64]  M. Fanselow,et al.  Contextual conditioning with massed versus distributed unconditional stimuli in the absence of explicit conditional stimuli. , 1988, Journal of experimental psychology. Animal behavior processes.

[65]  F. Momany,et al.  On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. , 1984, Endocrinology.

[66]  L. Swanson,et al.  Central noradrenergic pathways for the integration of hypothalamic neuroendocrine and autonomic responses. , 1981, Science.

[67]  M. Fanselow,et al.  Conditional and unconditional components of post-shock freezing , 1980, The Pavlovian journal of biological science.

[68]  I. Robinson,et al.  Mechanism of Action of GHRP-6 and Nonpeptidyl Growth Hormone Secretagogues , 1996 .

[69]  R. Steiner,et al.  Role of NPY neurones in GH-dependent feedback signalling to the brain. , 1996, Hormone research.

[70]  J. Herman,et al.  Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis. , 1996, Critical reviews in neurobiology.

[71]  S. Pong,et al.  Identification of a new G-protein-linked receptor for growth hormone secretagogues. , 1996, Molecular endocrinology.

[72]  C. Bowers Xenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides , 1996 .

[73]  J. P. Arena,et al.  Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. , 1996, Recent progress in hormone research.

[74]  R. Dyball,et al.  Central actions of peptide and non-peptide growth hormone secretagogues in the rat. , 1995, Neuroendocrinology.

[75]  J. Mcdonald,et al.  High concentrations of neuropeptide Y in pituitary portal blood of rats. , 1987, Neuroendocrinology.

[76]  W. Samson,et al.  Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[77]  F. Momany,et al.  Design, synthesis, and biological activity of peptides which release growth hormone in vitro. , 1981, Endocrinology.