Role of Cell Membrane-Vector Interactions in Successful Gene Delivery.
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[1] M. B. Banaszak Holl,et al. Cationic Polymer Intercalation into the Lipid Membrane Enables Intact Polyplex DNA Escape from Endosomes for Gene Delivery. , 2016, Molecular pharmaceutics.
[2] H. Al‐Hashimi,et al. Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. , 2016, Biomacromolecules.
[3] Mauro Ferrari,et al. Principles of nanoparticle design for overcoming biological barriers to drug delivery , 2015, Nature Biotechnology.
[4] Morgan L. Maeder,et al. Delivery and Specificity of CRISPR-Cas9 Genome Editing Technologies for Human Gene Therapy. , 2015, Human gene therapy.
[5] Rachel L Merzel,et al. Quantitative Measurement of Cationic Polymer Vector and Polymer-pDNA Polyplex Intercalation into the Cell Plasma Membrane. , 2015, ACS nano.
[6] Z. Gu,et al. Insight into the efficient transfection activity of a designed low aggregated magnetic polyethyleneimine/DNA complex in serum-containing medium and the application in vivo. , 2015, Biomaterials science.
[7] Daniel G. Anderson,et al. Non-viral vectors for gene-based therapy , 2014, Nature Reviews Genetics.
[8] M. B. Banaszak Holl,et al. Detergent Induction of HEK 293A Cell Membrane Permeability Measured under Quiescent and Superfusion Conditions Using Whole Cell Patch Clamp , 2014, The journal of physical chemistry. B.
[9] N. Ingle,et al. Spatiotemporal cellular imaging of polymer-pDNA nanocomplexes affords in situ morphology and trafficking trends. , 2013, Molecular pharmaceutics.
[10] M. B. Banaszak Holl,et al. Polyplex-induced cytosolic nuclease activation leads to differential transgene expression. , 2013, Molecular pharmaceutics.
[11] S. Pun,et al. Investigation of Polyethylenimine/DNA Polyplex Transfection to Cultured Cells Using Radiolabeling and Subcellular Fractionation Methods. , 2013, Molecular pharmaceutics.
[12] I. Zuhorn,et al. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. , 2013, ACS nano.
[13] Rebecca L. Matz,et al. Polyplex exposure inhibits cell cycle, increases inflammatory response, and can cause protein expression without cell division. , 2013, Molecular pharmaceutics.
[14] Eric C Freeman,et al. Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling , 2013, Journal of biomaterials science. Polymer edition.
[15] U. Schubert,et al. Polyelectrolyte complexes of DNA and linear PEI: formation, composition and properties. , 2012, Langmuir : the ACS journal of surfaces and colloids.
[16] H. Al‐Hashimi,et al. Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release. , 2012, Molecular pharmaceutics.
[17] Juliane Nguyen,et al. Nucleic acid delivery: the missing pieces of the puzzle? , 2012, Accounts of chemical research.
[18] T. Reineke,et al. Exploring the mechanism of plasmid DNA nuclear internalization with polymer-based vehicles. , 2012, Molecular pharmaceutics.
[19] M. Sullivan,et al. Polyplexes traffic through caveolae to the Golgi and endoplasmic reticulum en route to the nucleus. , 2012, Molecular pharmaceutics.
[20] T. Reineke,et al. Membrane and nuclear permeabilization by polymeric pDNA vehicles: efficient method for gene delivery or mechanism of cytotoxicity? , 2012, Molecular pharmaceutics.
[21] T. Andresen,et al. Elucidating the interplay between DNA-condensing and free polycations in gene transfection through a mechanistic study of linear and branched PEI. , 2011, Biomaterials.
[22] Marie C. M. Lin,et al. Revisit complexation between DNA and polyethylenimine - Effect of uncomplexed chains free in the solution mixture on gene transfection. , 2011, Journal of controlled release : official journal of the Controlled Release Society.
[23] N. Ingle,et al. Interaction of poly(ethylenimine)-DNA polyplexes with mitochondria: implications for a mechanism of cytotoxicity. , 2011, Molecular pharmaceutics.
[24] Iseult Lynch,et al. Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. , 2011, Journal of the American Chemical Society.
[25] Vincent M Rotello,et al. Effect of nanoparticle surface charge at the plasma membrane and beyond. , 2010, Nano letters.
[26] J. Brender,et al. Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes. , 2010, Journal of the American Chemical Society.
[27] M. Holl,et al. Polycation-induced cell membrane permeability does not enhance cellular uptake or expression efficiency of delivered DNA. , 2010, Molecular pharmaceutics.
[28] M. Holl,et al. The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway. , 2010, Molecular pharmaceutics.
[29] Seungpyo Hong,et al. Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes. , 2009, The journal of physical chemistry. B.
[30] Joseph M. Wallace,et al. Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes. , 2009, ACS nano.
[31] Seungpyo Hong,et al. The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimers. , 2009, Bioconjugate chemistry.
[32] E. Alton,et al. Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy. , 2009, Advanced drug delivery reviews.
[33] G. Wong,et al. Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids , 2008, Proceedings of the National Academy of Sciences.
[34] G. Wong,et al. Mechanism of A Prototypical Synthetic Membrane-Active Antimicrobial: Efficient Hole-Punching by Targeting Lipids With Negative Spontaneous Curvature Lipids , 2008 .
[35] Yun Zhou,et al. The size of sonoporation pores on the cell membrane , 2008, 2008 IEEE Ultrasonics Symposium.
[36] M. B. Banaszak Holl,et al. Interactions of poly(amidoamine) dendrimers with Survanta lung surfactant: the importance of lipid domains. , 2008, Langmuir : the ACS journal of surfaces and colloids.
[37] I. Andricioaei,et al. Poly(amidoamine) dendrimers on lipid bilayers I: Free energy and conformation of binding. , 2008, The journal of physical chemistry. B.
[38] I. Andricioaei,et al. Poly(amidoamine) dendrimers on lipid bilayers II: Effects of bilayer phase and dendrimer termination. , 2008, The journal of physical chemistry. B.
[39] Kristen N. Duthie,et al. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. , 2008, Nano letters.
[40] V. Ginzburg,et al. Modeling the thermodynamics of the interaction of nanoparticles with cell membranes. , 2007, Nano letters.
[41] Seungpyo Hong,et al. Nanoparticle interaction with biological membranes: does nanotechnology present a Janus face? , 2007, Accounts of chemical research.
[42] W. Hennink,et al. Cellular Uptake of Cationic Polymer-DNA Complexes Via Caveolae Plays a Pivotal Role in Gene Transfection in COS-7 Cells , 2007, Pharmaceutical Research.
[43] G. Lukács,et al. Nucleocytoplasmic transport of plasmid DNA: a perilous journey from the cytoplasm to the nucleus. , 2006, Human gene therapy.
[44] M. Monsigny,et al. Which mechanism for nuclear import of plasmid DNA complexed with polyethylenimine derivatives? , 2006, The journal of gene medicine.
[45] Seungpyo Hong,et al. Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. , 2006, Bioconjugate chemistry.
[46] B. Orr,et al. Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group. , 2005, Langmuir : the ACS journal of surfaces and colloids.
[47] B. Orr,et al. Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers. , 2005, Langmuir : the ACS journal of surfaces and colloids.
[48] M. Conese,et al. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[49] Rajan P Kulkarni,et al. Single cell kinetics of intracellular, nonviral, nucleic acid delivery vehicle acidification and trafficking. , 2005, Bioconjugate chemistry.
[50] S Moein Moghimi,et al. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[51] R. Langer,et al. Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis , 2005, The journal of gene medicine.
[52] Bradford G Orr,et al. Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers. , 2004, Chemistry and physics of lipids.
[53] C. Culmsee,et al. Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer , 2004, The journal of gene medicine.
[54] Seungpyo Hong,et al. Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. , 2004, Bioconjugate chemistry.
[55] Yuichi Yamasaki,et al. In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine , 2004, The journal of gene medicine.
[56] F. Szoka,et al. Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes* , 2003, Journal of Biological Chemistry.
[57] Thomas Kissel,et al. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. , 2003, Biomaterials.
[58] J. Wolff,et al. The effect of cell division on the cellular dynamics of microinjected DNA and dextran. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.
[59] D. Escande,et al. Ca2+‐sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids , 2001, The journal of gene medicine.
[60] M. Cotten,et al. Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus , 2000, Gene Therapy.
[61] G. Wilson,et al. Nuclear Import of Plasmid DNA in Digitonin-permeabilized Cells Requires Both Cytoplasmic Factors and Specific DNA Sequences* , 1999, The Journal of Biological Chemistry.
[62] I. Maclachlan,et al. Cationic lipid-mediated transfection of cells in culture requires mitotic activity , 1999, Gene Therapy.
[63] D. Fischer,et al. Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats. , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[64] K Mechtler,et al. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells , 1998, Gene Therapy.
[65] D. Escande,et al. Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells* , 1998, The Journal of Biological Chemistry.
[66] D. Dean,et al. Import of plasmid DNA into the nucleus is sequence specific. , 1997, Experimental cell research.
[67] D. Scherman,et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[68] J. Hagstrom,et al. Plasmid DNA entry into postmitotic nuclei of primary rat myotubes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[69] S Moein Moghimi,et al. The possible "proton sponge " effect of polyethylenimine (PEI) does not include change in lysosomal pH. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.
[70] W. Hennink,et al. Endosomal Escape of Polymeric Gene Delivery Complexes Is Not Always Enhanced by Polymers Buffering at Low pH , 2004 .