Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.

A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.

[1]  M. Levin.  Left‐right asymmetry in vertebrate embryogenesis , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[2]  R. Beddington,et al.  Axis Development and Early Asymmetry in Mammals , 1999, Cell.

[3]  J. Rodríguez-Rey,et al.  Pitx2 Participates in the Late Phase of the Pathway Controlling Left-Right Asymmetry , 1998, Cell.

[4]  H. Yost,et al.  Molecular mechanisms of vertebrate left-right development. , 1998, Trends in genetics : TIG.

[5]  S. P. Oh,et al.  The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. , 1997, Genes & development.

[6]  E. Li,et al.  Smad2 role in mesoderm formation, left–right patterning and craniofacial development , 1998, Nature.

[7]  R. Harvey,et al.  Links in the Left/Right Axial Pathway , 1998, Cell.

[8]  H. Yost,et al.  Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. , 1996, Developmental biology.

[9]  C. Lo,et al.  No turning, a mouse mutation causing left-right and axial patterning defects. , 1998, Developmental biology.

[10]  J. Collignon,et al.  Relationship between asymmetric nodal expression and the direction of embryonic turning , 1996, Nature.

[11]  H. Yost,et al.  Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development. , 1997, Development.

[12]  R. Beddington,et al.  The role of the brachyury gene in heart development and left–right specification in the mouse , 1998, Mechanisms of Development.

[13]  G. Martin,et al.  An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination , 1998, Nature Genetics.