Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform

A platform for multiplexed detection of several biomolecular events, simultaneously at the same instant of time, is highly desirable in biomolecular diagnostics. Silicon Photonics is ideally suited for the above requirement. Our biosensor comprises a PC microcavity coupled to a PC waveguide. High sensitivities were achieved by slow light engineering which reduced the radiation loss and increased the stored energy in the photonic crystal microcavity resonance mode. Resonances with high quality factor Q~26,760 coupled with larger optical mode volumes allowed enhanced interaction with the analyte biomolecules which resulted in sensitivities down to 3.35pg/ml. We have multiplexed up to 64 PC microcavities in series and parallel for high throughput multiplexing using silicon integrated photonic components such as multimode interference power splitters combined with advanced group index engineering.

[1]  David Galas,et al.  Surface plasmon resonance biosensor for rapid label-free detection of microribonucleic acid at subfemtomole level. , 2010, Analytical chemistry.

[2]  Philippe M. Fauchet,et al.  Resonant Microcavities Coupled to a Photonic Crystal Waveguide for Multi-channel Biodetection , 2009 .

[3]  P. Fauchet,et al.  Two-dimensional silicon photonic crystal based biosensing platform for protein detection. , 2007, Optics express.

[4]  D. Erickson,et al.  Nanoscale optofluidic sensor arrays. , 2008, Optics express.

[5]  Ray T. Chen,et al.  Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors. , 2013, Biosensors & bioelectronics.

[6]  Ray T. Chen,et al.  Slow light engineering for high Q high sensitivity photonic crystal microcavity biosensors in silicon. , 2012, Biosensors & bioelectronics.

[7]  Sanja Zlatanovic,et al.  Photonic crystal microcavity sensor for ultracompact monitoring of reaction kinetics and protein concentration , 2009 .

[8]  Ray T. Chen,et al.  Cavity-Waveguide Coupling Engineered High Sensitivity Silicon Photonic Crystal Microcavity Biosensors With High Yield , 2014, IEEE Journal of Selected Topics in Quantum Electronics.

[9]  Ray T. Chen,et al.  Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform. , 2012, Lab on a chip.

[10]  Martin Kristensen,et al.  Photonic-crystal waveguide biosensor. , 2007, Optics express.

[11]  Ray T. Chen,et al.  Slow light enhanced sensitivity of resonance modes in photonic crystal biosensors. , 2013, Applied physics letters.

[12]  Ray T. Chen,et al.  Silicon nano-membrane based photonic crystal microcavities for high sensitivity bio-sensing. , 2012, Optics letters.

[13]  Annette Grot,et al.  Ultra compact biochemical sensor built with two dimensional photonic crystal microcavity , 2004 .

[14]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[15]  S. Zlatanovic,et al.  Toward, single molecule detection with photonic crystal microcavity biosensors , 2006, 2006 Digest of the LEOS Summer Topical Meetings.

[16]  Xiaolong Wang,et al.  Ultraefficient control of light transmission through photonic potential barrier modulation. , 2009, Optics letters.

[17]  A Densmore,et al.  Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection. , 2009, Optics letters.