Autoantibodies against Oxidized LDL in the First Phase of Life

Abstract The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p < 0.001). Its concentration in newborns was even higher than in their mothers (p < 0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.

[1]  A. Tenenbaum,et al.  Autoantibodies to oxidized low-density lipoprotein in coronary artery disease. , 2001, American journal of hypertension.

[2]  M. Flamand,et al.  La mort cellulaire par apoptose en réponse à l’infection par le virus de la dengue : quelles conséquences dans la pathogénie virale ? , 1998 .

[3]  J. Cristol,et al.  [Evaluation of lipid peroxidation by measuring thiobarbituric acid reactive substances]. , 1998, Annales de biologie clinique.

[4]  J. Ross.  The timing of surgery for severe mitral regurgitation. , 1996, The New England journal of medicine.

[5]  J. Boer,et al.  Autoantibodies against MDA-LDL in subjects with severe and minor atherosclerosis and healthy population controls. , 1996, Atherosclerosis.

[6]  O. Impivaara,et al.  Serum concentrations of apolipoprotein A-I, apolipoprotein B, and lipoprotein(a) in a population sample. , 1995, Clinical chemistry.

[7]  J. Witztum,et al.  The oxidation hypothesis of atherosclerosis , 1994, The Lancet.

[8]  C. Rice-Evans,et al.  A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. , 1993, Clinical science.

[9]  J. Salonen,et al.  Autoantibody against oxidised LDL and progression of carotid atherosclerosis , 1992, The Lancet.

[10]  Gerald S. Berenson,et al.  Autopsy Studies in United States Children and Adolescents a , 1991 .

[11]  R. Ross.  The pathogenesis of atherosclerosis--an update. , 1986, The New England journal of medicine.

[12]  J. Ordovás,et al.  Plasma Lipids and Cholesterol Esterification Rate During Pregnancy , 1984, Obstetrics and gynecology.

[13]  C. S. Devi,et al.  Concentration of triglyceride and cholesterol in lipoprotein fractions in maternal and cord blood samples. , 1982, Clinica chimica acta; international journal of clinical chemistry.

[14]  F. Stožický,et al.  THE PATTERN OF MAJOR SERUM APOLIPOPROTEINS DURING THE EARLY NEONATAL PERIOD , 1982, Acta paediatrica Scandinavica.

[15]  M. Childs,et al.  Lipid metabolism in pregnancy. VII. Kinetics of chylomicron triglyceride removal in fed pregnant rat. , 1980, The American journal of physiology.

[16]  W. Mcconathy,et al.  Studies on the Apolipoproteins and Lipoproteins of Cord Serum , 1980, Pediatric Research.

[17]  A. Gustafson,et al.  STUDIES IN NORMAL PREGNANCY — SERUM LIPIDS, LIPOPROTEINS, AND URIC ACID (II) , 1980, Acta obstetricia et gynecologica Scandinavica.

[18]  P. Nestel,et al.  The hyperlipidemia of pregnancy in normal and complicated pregnancies. , 1979, American journal of obstetrics and gynecology.

[19]  L. Carlson,et al.  Concentration and composition of human serum lipoproteins at birth. , 1978, Clinica chimica acta; international journal of clinical chemistry.

[20]  S. Friedberg,et al.  Mechanism of avian estrogen-induced hypertriglyceridemia: evidence for overproduction of triglyceride. , 1975, Journal of lipid research.

[21]  B. Persson,et al.  The Pattern of Blood Lipids, Glycerol and Ketone Bodies during the Neonatal Period, Infancy and Childhood , 1966, Acta paediatrica Scandinavica.

[22]  J. Strong,et al.  The natural history of atherosclerosis: the early aortic lesions as seen in New Orleans in the middle of the of the 20th century. , 1958, The American journal of pathology.

[23]  J. Berliner,et al.  The role of oxidized lipoproteins in atherogenesis. , 1996, Free radical biology & medicine.

[24]  W. G. Wood,et al.  Lipoprotein(a) Concentrations in Non-Selected Hospitalised Patients Between 18 and 100 Years of Age: Comparison with Cholesterol Fractions and Triacylglycerols in Patients with Lipid Status Requests , 1995, European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.

[25]  W. G. Wood,et al.  (Apo)lipoprotein(a) Concentrations at Birth and in the First Days and Months of Life — Studies on the Distribution of Serum Levels and the Predictive Value of Measurements Made at this Time , 1995, European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.

[26]  H. Esterbauer,et al.  Lipid peroxidation and its role in atherosclerosis. , 1993, British medical bulletin.

[27]  G. Berenson,et al.  Autopsy studies in United States children and adolescents. Relationship of risk factors to atherosclerotic lesions. , 1991, Annals of the New York Academy of Sciences.

[28]  H. C. Stary.  Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. , 1989, Arteriosclerosis.

[29]  F. Bombelli,et al.  Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Maternal and Cord Blood Erythrocytes , 1980, Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.

[30]  R. Shaher,et al.  Cord blood hyperlipoproteinemia and perinatal stress. , 1977, Pediatric research.