Cardiovascular safety of fexofenadine HCl

Certain first‐ and second‐generation H1‐receptor antagonists are associated with prolongation of the corrected QT interval (QTc) and, in rare instances, with ventricular dysrhythmias, including torsades de pointes ventricular tachycardia.

[1]  C. Falliers,et al.  Effectiveness and safety of fexofenadine, a new nonsedating H1-receptor antagonist, in the treatment of fall allergies. , 1998, Allergy and asthma proceedings.

[2]  D. Bernstein,et al.  Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis. , 1997, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[3]  A. E. Lacerda,et al.  Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart. , 1997, Molecular pharmacology.

[4]  A. Brown Cardiac potassium channels in health and disease. , 1997, Trends in cardiovascular medicine.

[5]  J. Ruskin,et al.  Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability. , 1996, American heart journal.

[6]  R. Woosley,et al.  Cardiac actions of antihistamines. , 1996, Annual review of pharmacology and toxicology.

[7]  J. Kemp,et al.  Efficacy and safety of inhaled bitolterol mesylate via metered-dose inhaler in children with asthma. , 1996, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[8]  C. Pratt,et al.  Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. , 1994, The American journal of cardiology.

[9]  A. Brown,et al.  Effects of terfenadine and its metabolites on a delayed rectifier K+ channel cloned from human heart. , 1993, Molecular pharmacology.

[10]  Y Chen,et al.  Mechanism of the cardiotoxic actions of terfenadine. , 1993, JAMA.

[11]  D. Wortham,et al.  Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences. , 1993, JAMA.

[12]  R. Woosley,et al.  Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin , 1992, Clinical pharmacology and therapeutics.

[13]  P. Lévy,et al.  Torsades de Pointes after treatment with terfenadine and ketoconazole. , 1992, European heart journal.

[14]  M. Eo,et al.  Comparative safety of H1 antihistamines. , 1991 .

[15]  C. L. Ferguson,et al.  Torsades de pointes occurring in association with terfenadine use. , 1990, JAMA.

[16]  E. Meltzer Antihistamine- and decongestant-induced performance decrements. , 1990, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[17]  Tarnasky Pr,et al.  Antihistamine therapy in allergic rhinitis. , 1990 .

[18]  C. Stafford Allergic rhinitis. A useful guide to diagnosis and treatment. , 1987, Postgraduate medicine.

[19]  H. Bazett,et al.  AN ANALYSIS OF THE TIME‐RELATIONS OF ELECTROCARDIOGRAMS. , 1997 .