Insulin analogs with improved pharmacokinetic profiles.
暂无分享,去创建一个
[1] J L Whittingham,et al. Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 pro --> Asp insulin analogues. , 1998, Biochemistry.
[2] R. Guy,et al. Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. , 1998, Journal of controlled release : official journal of the Controlled Release Society.
[3] B. Frier,et al. Optimal Time of Administration of Insulin Lispro. Importance of meal composition , 1998, Diabetes Care.
[4] P. Home,et al. The Effect of the Insulin Analog Lispro on Nighttime Blood Glucose Control in Type 1 Diabetic Patients , 1998, Diabetes Care.
[5] L. Vignati,et al. Basal activity profiles of NPH and [Nɛ-palmitoyl Lys (B29)] human insulins in subjects with IDDM , 1998, Diabetologia.
[6] R. Heine,et al. Nighttime Insulin Kinetics and Glycemic Control in Type 1 Diabetes Patients Following Administration of an Intermediate-Acting Lispro Preparation , 1997, Diabetes Care.
[7] F. Holleman,et al. Reduced Frequency of Severe Hypoglycemia and Coma in Well-Controlled IDDM Patients Treated With Insulin Lispro , 1997, Diabetes Care.
[8] L. Heinemann,et al. Insulin Aspart in a 30/70 Premixed Formulation: Pharmacodynamic properties of a rapid-acting insulin analog in stable mixture , 1997, Diabetes Care.
[9] M. Feinglos,et al. Modification of Postprandial Hyperglycemia With Insulin Lispro Improves Glucose Control in Patients With Type 2 Diabetes , 1997, Diabetes Care.
[10] D. Kumar. Lispro Analog for Treatment of Generalized Allergy to Human Insulin , 1997, Diabetes Care.
[11] R. Heine,et al. Metabolic Efficacy of Preprandial Administration of Lys(B28), Pro(B29) Human Insulin Analog in IDDM Patients: A comparison with human regular insulin during a three-meal test period , 1997, Diabetes Care.
[12] P. Jansson,et al. Strategies Toward Improved Control During Insulin Lispro Therapy in IDDM: Importance of basal insulin , 1997, Diabetes Care.
[13] B. Zinman,et al. Stability of Insulin Lispro in Insulin Infusion Systems , 1997, Diabetes Care.
[14] L. Vignati,et al. Mealtime treatment with insulin analog improves postprandial hyperglycemia and hypoglycemia in patients with non-insulin-dependent diabetes mellitus. Multicenter Insulin Lispro Study Group. , 1997, Archives of internal medicine.
[15] J. Clore,et al. Mixing Insulin Lispro and Ultralente Insulin , 1997, Diabetes Care.
[16] L. Vignati,et al. Health-Related Quality-of-Life Results From Multinational Clinical Trials of Insulin Lispro: Assessing benefits of a new diabetes therapy , 1997, Diabetes Care.
[17] L. Heinemann,et al. Are presently available insulin analogues clinically beneficial? , 1997, Diabetologia.
[18] L. Slieker,et al. Modifications in the B10 and B26–30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor , 1997, Diabetologia.
[19] J. Brange,et al. The new era of biotech insulin analogues , 1997, Diabetologia.
[20] J. Brange,et al. Toward understanding insulin fibrillation. , 1997, Journal of pharmaceutical sciences.
[21] R. DiMarchi,et al. Bioavailability and Bioeffectiveness of Subcutaneous Human Insulin and Two of its Analogs—LysB28ProB29-Human Insulin and AspB10LysB28ProB29-Human Insulin—Assessed in a Conscious Pig Model , 1997, Diabetes.
[22] S. R. Myers,et al. Acylation of Human Insulin With Palmitic Acid Extends the Time Action of Human Insulin in Diabetic Dogs , 1997, Diabetes.
[23] J. Whittingham,et al. Crystal structure of a prolonged-acting insulin with albumin-binding properties. , 1997, Biochemistry.
[24] B. Zinman,et al. Insulin Lispro in CSII: Results of a Double-Blind Crossover Study , 1997, Diabetes.
[25] M. Burge,et al. Prolonged efficacy of short acting insulin Lispro in combination with human ultralente in insulin-dependent diabetes mellitus. , 1997, The Journal of clinical endocrinology and metabolism.
[26] N. Bohannon. Benefits of lispro insulin: control of postprandial glucose levels is within reach. , 1997, Postgraduate medicine.
[27] M. Burge,et al. Meal Composition is a Determinant of Lispro-Induced Hypoglycemia in IDDM , 1997, Diabetes Care.
[28] L. Vignati,et al. Reduction of Postprandial Hyperglycemia and Frequency of Hypoglycemia in IDDM Patients on Insulin-Analog Treatment , 1997, Diabetes.
[29] M. Knip,et al. Severe Antibody-Mediated Human Insulin Resistance: Successful Treatment With the Insulin Analog Lispro: A case report , 1997, Diabetes Care.
[30] L. Vignati,et al. Improved mealtime treatment of diabetes mellitus using an insulin analogue. Multicenter Insulin Lispro Study Group. , 1997, Clinical therapeutics.
[31] M. Trautmann,et al. Intensive insulin therapy with insulin lispro in patients with type 1 diabetes reduces the frequency of hypoglycemic episodes. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
[32] J. Thijssen,et al. Injection Site Effects on the Pharmacokinetics and Glucodynamics of Insulin Lispro and Regular Insulin , 1996, Diabetes Care.
[33] J. M. Beals,et al. Physicochemical basis for the rapid time‐action of LysB28ProB29‐insulin: Dissociation of a protein‐ligand complex , 1996, Protein science : a publication of the Protein Society.
[34] N. Fineberg,et al. Immunologic Effects of Insulin Lispro [Lys (B28), Pro (B29) Human Insulin] in IDDM and NIDDM Patients Previously Treated With Insulin , 1996, Diabetes.
[35] M. Trautmann,et al. Severe insulin resistance treated with insulin lispro , 1996, The Lancet.
[36] P. Brunetti,et al. Effects of the Short-Acting Insulin Analog [Lys(B28),Pro(B29)] on Postprandial Blood Glucose Control in IDDM , 1996, Diabetes Care.
[37] L Heinemann,et al. Prandial Glycaemia After a Carbohydrate‐rich Meal in Type I Diabetic Patients: Using the Rapid Acting Insulin Analogue [Lys(B28), Pro(B29)] Human Insulin , 1996, Diabetic medicine : a journal of the British Diabetic Association.
[38] H. Chase,et al. Pre‐meal Insulin Analogue Insulin Lispro vs Humulin® R Insulin Treatment in Young Subjects with Type 1 Diabetes , 1996, Diabetic medicine : a journal of the British Diabetic Association.
[39] U. Ribel,et al. Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo. , 1995, The Biochemical journal.
[40] U. Ribel,et al. Action Profile of Cobalt(III)-Insulin: A Novel Principle of Protraction of Potential Use for Basal Insulin Delivery , 1995, Diabetes.
[41] L. Heinemann,et al. Time-action profiles of the intermediate-acting insulin analogue des(64,65)-human proinsulin. , 1995, Diabete & metabolisme.
[42] P. Brunetti,et al. Improved Postprandial Metabolic Control After Subcutaneous Injection of a Short-Acting Insulin Analog in IDDM of Short Duration With Residual Pancreatic β-Cell Function , 1995, Diabetes Care.
[43] P. Kurtzhals,et al. The cobalt(III)-insulin hexamer is a prolonged-acting insulin prodrug. , 1995, Journal of pharmaceutical sciences.
[44] D. Howey,et al. [Lys(B28), Pro(B29)]‐human insulin: Effect of injection time on postprandial glycemia , 1995, Clinical pharmacology and therapy.
[45] F. Gries,et al. Insulinkinetic and -Dynamic in Diabetic Patients Under Insulin Pump Therapy After Injections of Human Insulin or the Insulin Analogue (B28Asp) , 1995, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[46] J. M. Beals,et al. Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin. , 1995, Structure.
[47] D. Howey,et al. [Lys(B28), Pro(B29)]-Human Insulin: A Rapidly Absorbed Analogue of Human Insulin , 1994, Diabetes.
[48] L. Slieker,et al. Preparation of an insulin with improved pharmacokinetics relative to human insulin through consideration of structural homology with insulin-like growth factor I. , 1994, Hormone research.
[49] Z Trajanoski,et al. Pharmacokinetic Model for the Absorption of Subcutaneously Injected Soluble Insulin and Monomeric Insulin - Analogues - Pharmakokinetisches Modell für die Absorption von subkutan injiziertem löslichem Insulin und monomeren Insulinanaloga , 1993, Biomedizinische Technik. Biomedical engineering.
[50] L. Heinemann,et al. Action Profile of the Rapid Acting Insulin Analogue: Human Insulin B28Asp , 1993, Diabetic medicine : a journal of the British Diabetic Association.
[51] E J Dodson,et al. Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin. , 1992, Journal of molecular biology.
[52] K. Drejer. The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. , 1992, Diabetes/metabolism reviews.
[53] B H Frank,et al. Altering the association properties of insulin by amino acid replacement. , 1992, Protein engineering.
[54] E. Dodson,et al. Mutant insulin crystal packing , 1992 .
[55] D. Howey,et al. Biosynthetic Human Proinsulin: Review of Chemistry, in Vitro and in Vivo Receptor Binding, Animal and Human Pharmacology Studies, and Clinical Trial Experience , 1992, Diabetes Care.
[56] S. Shoelson,et al. Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions. , 1992, Biochemistry.
[57] J. Brange,et al. Designing insulin for diabetes therapy by protein engineering , 1992, Current Biology.
[58] D. Brems,et al. Synthesis of a Fast-Acting Insulin Based on Structural Homology with Insulin-Like Growth Factor I, , 1992 .
[59] J. Brange,et al. Chemical stability of insulin. 3. Influence of excipients, formulation, and pH. , 1992, Acta pharmaceutica Nordica.
[60] D R Owens,et al. Absorption Kinetics and Action Profiles of Subcutaneously Administered Insulin Analogues (AspB9GluB27, AspB10, AspB28) in Healthy Subjects , 1991, Diabetes Care.
[61] U. Ribel,et al. In Vitro and In Vivo Potency of Insulin Analogues Designed for Clinical Use , 1991, Diabetic medicine : a journal of the British Diabetic Association.
[62] D R Owens,et al. Subcutaneous Insulin Absorption Explained by Insulin's Physicochemical Properties: Evidence From Absorption Studies of Soluble Human Insulin and Insulin Analogues in Humans , 1991, Diabetes Care.
[63] S. Shoelson,et al. Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design. , 1991, Biochemistry.
[64] D. Owens,et al. Comparison of Subcutaneous Soluble Human Insulin and Insulin Analogues (AspB9, GluB27; AspB10; AspB28) on Meal-Related Plasma Glucose Excursions in Type I Diabetic Subjects , 1991, Diabetes Care.
[65] D R Owens,et al. Monomeric Insulins and Their Experimental and Clinical Implications , 1990, Diabetes Care.
[66] P. Hougaard,et al. Equivalent In Vivo Biological Activity of Insulin Analogues and Human Insulin Despite Different In Vitro Potencies , 1990, Diabetes.
[67] M. Roy,et al. Sequence-specific 1H-NMR assignments for the aromatic region of several biologically active, monomeric insulins including native human insulin. , 1990, Biochimica et biophysica acta.
[68] M. Roy,et al. 1H NMR spectrum of the native human insulin monomer. Evidence for conformational differences between the monomer and aggregated forms. , 1990, The Journal of biological chemistry.
[69] D. Owens,et al. Comparison of insulin analogue B9AspB27Glu and soluble human insulin in insulin-treated diabetes , 1990, The Lancet.
[70] W. C. Johnson,et al. Changes in secondary structure follow the dissociation of human insulin hexamers: A circular dichroism study , 1990, Proteins.
[71] E. Kraegen,et al. Quantitative Aspects of Subcutaneous Insulin Absorption , 1989, Diabetic medicine : a journal of the British Diabetic Association.
[72] A. Vaag,et al. NovoSol Basal: pharmacokinetics of a novel soluble long acting insulin analogue. , 1989, BMJ.
[73] M. Dunn,et al. Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin. , 1989, Biochemistry.
[74] E. Dodson,et al. Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer , 1989, Nature.
[75] P. Home,et al. Insulin treatment: a decade of change. , 1989, British medical bulletin.
[76] D. Owens,et al. Recombinant DNA derived monomeric insulin analogue: comparison with soluble human insulin in normal subjects. , 1988, BMJ.
[77] T L Blundell,et al. The structure of 2Zn pig insulin crystals at 1.5 A resolution. , 1988, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[78] P. Hougaard,et al. Soluble, prolonged-acting insulin derivatives. III. Degree of protraction, crystallizability and chemical stability of insulins substituted in positions A21, B13, B23, B27 and B30. , 1988, Protein engineering.
[79] J. Brange,et al. Monomeric insulins obtained by protein engineering and their medical implications , 1988, Nature.
[80] K. Polonsky,et al. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. , 1988, The Journal of clinical investigation.
[81] L. Thim,et al. BIOSYNTHESIS OF HUMAN INSULIN IN YEAST VIA SINGLE-CHAIN PRECURSORS , 1987 .
[82] H. Kelders,et al. GROWING-CRYSTALS BY ROBOTICS , 1987 .
[83] P. Hougaard,et al. Soluble, prolonged-acting insulin derivatives. II. Degree of protraction and crystallizability of insulins substituted in positions A17, B8, B13, B27 and B30. , 1987, Protein engineering.
[84] P. Hougaard,et al. Soluble, prolonged-acting insulin derivatives. I. Degree of protraction and crystallizability of insulins substituted in the termini of the B-chain. , 1987, Protein engineering.
[85] R. Arakaki,et al. The pharmacokinetics of subcutaneous regular insulin in type I diabetic patients: assessment using a glucose clamp technique. , 1986, The Journal of clinical endocrinology and metabolism.
[86] L. Thim,et al. Secretion and processing of insulin precursors in yeast. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[87] T. M. Hayes,et al. Human, Porcine and Bovine Ultralente Insulin: Subcutaneous Administration in Normal Man , 1986, Diabetic medicine : a journal of the British Diabetic Association.
[88] K. Alberti,et al. Human ultralente insulin: a comparison with porcine lente insulin as a twice-daily insulin in insulin-dependent diabetic patients with fasting hyperglycaemia. , 1986, Diabetes research.
[89] G. Dimitriadis,et al. Importance of Timing of Preprandial Subcutaneous Insulin Administration in the Management of Diabetes Mellitus , 1983, Diabetes Care.
[90] K. Alberti,et al. Continuous subcutaneous insulin infusion: comparison of plasma insulin profiles after infusion or bolus injection of the mealtime dose. , 1981, Metabolism: clinical and experimental.
[91] J. A. Hoffmann,et al. Chemical, Physical, and Biologic Properties of Biosynthetic Human Insulin , 1981, Diabetes Care.
[92] R. Bilous,et al. HUMAN INSULIN PRODUCED BY RECOMBINANT DNA TECHNOLOGY: SAFETY AND HYPOGLYCÆMIC POTENCY IN HEALTHY MEN , 1980, The Lancet.
[93] M. Chou,et al. Time-action characteristics of regular and NPH insulin in insulin-treated diabetics. , 1980, The Journal of clinical endocrinology and metabolism.
[94] A. Riggs,et al. Expression in Escherichia coli of chemically synthesized genes for human insulin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[95] J. Schlichtkrull. THE ABSORPTION OF INSULIN , 1977, Acta paediatrica Scandinavica. Supplement.
[96] W. Rutter,et al. Rat insulin genes: construction of plasmids containing the coding sequences. , 1977, Science.
[97] Tom L. Blundell,et al. Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by , 1972 .
[98] Thomas Jh. Electrophoresis of ( 35 S) sulphated insulin. Immunological and biological properties of the isolated electrophoretic components. , 1971 .
[99] L. Winterscheid,et al. Hypoglycemic activity and immunological half-life of porcine insulin and proinsulin in baboons and swine. , 1971, Endocrinology.
[100] C. Binder. Absorption of injected insulin. A clinical-pharmacological study. , 2009, Acta pharmacologica et toxicologica.
[101] E. Baker,et al. Structure of Rhombohedral 2 Zinc Insulin Crystals , 1969, Nature.
[102] G. B. Dowling,et al. Vitamin D in cutaneous tuberculosis. , 1947, Lancet.