Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements.
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[1] T. Osborne,et al. Selective Association of Sterol Regulatory Element-binding Protein Isoforms with Target Promoters in Vivo* , 2004, Journal of Biological Chemistry.
[2] Guoxun Chen,et al. Trace: Tennessee Research and Creative Exchange Nutrition Publications and Other Works Nutrition Central Role for Liver X Receptor in Insulin-mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Recommended Citation , 2022 .
[3] R. Hammer,et al. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. , 2004, The Journal of clinical investigation.
[4] H. T. Kang,et al. Down-regulation of Sp1 Activity through Modulation of O-Glycosylation by Treatment with a Low Glucose Mimetic, 2-Deoxyglucose* , 2003, Journal of Biological Chemistry.
[5] Xiaoyong Yang,et al. O-GlcNAc Modification Is an Endogenous Inhibitor of the Proteasome , 2003, Cell.
[6] K. Morino,et al. Protein-tyrosine Phosphatase 1B as New Activator for Hepatic Lipogenesis via Sterol Regulatory Element-binding Protein-1 Gene Expression* , 2003, Journal of Biological Chemistry.
[7] R. Raghow,et al. O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon. , 2003, American journal of physiology. Endocrinology and metabolism.
[8] X. Hu,et al. Liver X receptors interact with corepressors to regulate gene expression. , 2003, Molecular endocrinology.
[9] J. Ericsson,et al. Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors , 2003, Molecular and Cellular Biology.
[10] S. Samson,et al. Role of Sp1 in insulin regulation of gene expression. , 2002, Journal of molecular endocrinology.
[11] S. Philipsen,et al. Regulation of the activity of Sp1-related transcription factors , 2002, Molecular and Cellular Endocrinology.
[12] P. Morin,et al. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. , 2002, Experimental cell research.
[13] G. Rutter,et al. Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells. , 2002, Diabetes.
[14] J. Gustafsson,et al. Liver X Receptors as Insulin-mediating Factors in Fatty Acid and Cholesterol Biosynthesis* , 2002, The Journal of Biological Chemistry.
[15] R. Hammer,et al. Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c* , 2002, The Journal of Biological Chemistry.
[16] Suzhen Li,et al. Induction of Human Liver X Receptor α Gene Expression Via an Autoregulatory Loop Mechanism , 2002 .
[17] G. Hart,et al. The emerging significance of O-GlcNAc in cellular regulation. , 2002, Chemical reviews.
[18] X. Deng,et al. Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. , 2002, Biochemical and biophysical research communications.
[19] Minoru Yoshida,et al. Direct Demonstration of Rapid Degradation of Nuclear Sterol Regulatory Element-binding Proteins by the Ubiquitin-Proteasome Pathway* , 2001, The Journal of Biological Chemistry.
[20] D. Jump,et al. Functional Interaction between Sterol Regulatory Element-binding Protein-1c, Nuclear Factor Y, and 3,5,3′-Triiodothyronine Nuclear Receptors* , 2001, The Journal of Biological Chemistry.
[21] Hitoshi Shimano,et al. Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter , 2001, Molecular and Cellular Biology.
[22] R. Raghow,et al. Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat. , 2001, Endocrinology.
[23] S. Clarke,et al. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. , 2001, The Journal of nutrition.
[24] D Tabor,et al. Regulation of gene expression by SREBP and SCAP. , 2000, Biochimica et biophysica acta.
[25] D. Mangelsdorf,et al. Role of LXRs in control of lipogenesis. , 2000, Genes & development.
[26] Jean-Marc A. Lobaccaro,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .
[27] D. Müller-Wieland,et al. MAP Kinases Erk1/2 Phosphorylate Sterol Regulatory Element-binding Protein (SREBP)-1a at Serine 117 in Vitro * , 2000, The Journal of Biological Chemistry.
[28] J. Swinnen,et al. Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway , 2000, Oncogene.
[29] I. G. Fantus,et al. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[30] T. Osborne,et al. Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action* , 2000, The Journal of Biological Chemistry.
[31] H. Shimano,et al. Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene* , 2000, The Journal of Biological Chemistry.
[32] K. Kim,et al. The Roles of Sterol Regulatory Element-binding Proteins in the Transactivation of the Rat ATP Citrate-Lyase Promoter* , 2000, The Journal of Biological Chemistry.
[33] M. Foretz,et al. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. , 2000, The Biochemical journal.
[34] T. Osborne,et al. Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase* , 2000, The Journal of Biological Chemistry.
[35] I. Shimomura,et al. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[36] M. Foretz,et al. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Brown,et al. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[38] M. Schweizer,et al. Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. , 1999, Gene.
[39] D. Peet,et al. The LXRs: a new class of oxysterol receptors. , 1998, Current opinion in genetics & development.
[40] B. Knebel,et al. ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway. , 1998, Biochemical and biophysical research communications.
[41] I. Shimomura,et al. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[42] P. Edwards,et al. Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein. , 1998, Journal of lipid research.
[43] T. Osborne,et al. Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1 , 1997, Molecular and cellular biology.
[44] T. Osborne,et al. Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins. , 1997, Journal of lipid research.
[45] I. Han,et al. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility , 1997, Molecular and cellular biology.
[46] I. Shimomura,et al. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. , 1997, The Journal of clinical investigation.
[47] R. Hammer,et al. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. , 1997, The Journal of clinical investigation.
[48] B. Oskouian,et al. Identification of an Inverted CCAAT Box Motif in the Fatty-acid Synthase Gene as an Essential Element for Mediation of Transcriptional Regulation by cAMP (*) , 1996, The Journal of Biological Chemistry.
[49] T. Osborne,et al. Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[50] B. Spiegelman,et al. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain , 1995, Molecular and cellular biology.
[51] Y. Paik,et al. Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 8-isomerase. , 1995, Journal of biochemistry.
[52] H. Hobbs,et al. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. , 1995, Genomics.
[53] R. Raghow,et al. Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[54] K. Schey,et al. High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin. , 2003, American journal of physiology. Endocrinology and metabolism.
[55] B. Knebel,et al. Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade. , 2000, Journal of lipid research.
[56] B. Spiegelman,et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. , 1998, The Journal of clinical investigation.