Colchicine myopathy in a patient with familial Mediterranean fever and normal renal function.

Introduction Patients with familial Mediterranean fever (FMF) routinely take large daily doses of colchicine to both prevent and abort acute attacks (1,2) and to reduce the risk of developing amyloidosis (3). Unfortunately, colchicine can also cause a number of toxic side effects, including neuromyopathy. Almost all cases of colchicine neuromyopathy previously described have been associated with renal insufficiency (4). We report the first case of biopsy-confirmed myopathy due to chronic colchicine administration in an adult with FMF and normal renal function.

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