Digital tuning of the quality factor of micromechanical resonant biological detectors

We present a new technique to increase the quality factor of micro-nanomechanicl oscillators using digital electronics. The mechanical oscillator is set into oscillation by using a single driving force whose amplitude depends on the amplitude and phase shift of the oscillation. Experiments performed with microcantilevers in air and aqueous solution show that the quality factor can be increased about two orders of magnitude. This technique is applied for the measurement of the viscosity change of an aqueous solution due to the presence of proteins.

[1]  H. Rothuizen,et al.  Translating biomolecular recognition into nanomechanics. , 2000, Science.

[2]  T. Thundat,et al.  Bioassay of prostate-specific antigen (PSA) using microcantilevers , 2001, Nature Biotechnology.

[3]  John E. Sader,et al.  Experimental validation of theoretical models for the frequency response of atomic force microscope cantilever beams immersed in fluids , 2000 .

[4]  Thomas Thundat,et al.  RESONANCE RESPONSE OF SCANNING FORCE MICROSCOPY CANTILEVERS , 1994 .

[5]  M. Grattarola,et al.  Micromechanical cantilever-based biosensors , 2001 .

[6]  M. Blencowe Nanoelectromechanical systems , 2005, cond-mat/0502566.

[7]  A K Chakraborty,et al.  Origin of nanomechanical cantilever motion generated from biomolecular interactions. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[8]  M. Welland,et al.  Microcantilever-based biosensors , 2000, Ultramicroscopy.

[9]  Velko P. Tzolov,et al.  Theoretical analysis of birefringence and form‐induced polarization mode dispersion in birefringent optical fibers: A full‐vectorial approach , 1995 .

[10]  Xavier Borrisé,et al.  Electromechanical model of a resonating nano-cantilever-based sensor for high-resolution and high-sensitivity mass detection , 2001 .

[11]  Hans-Jürgen Butt,et al.  A Sensitive Method to Measure Changes in the Surface Stress of Solids , 1996 .

[12]  Christiane Ziegler,et al.  Cantilever-based biosensors , 2004, Analytical and bioanalytical chemistry.

[13]  James K. Gimzewski,et al.  Micromechanics: a toolbox for femtoscale science: “Towards a laboratory on a tip” , 1997 .

[14]  Gil U. Lee,et al.  Direct measurement of the forces between complementary strands of DNA. , 1994, Science.

[15]  H. Craighead,et al.  Mechanical resonant immunospecific biological detector , 2000 .

[16]  T. Thundat,et al.  Manipulation and controlled amplification of Brownian motion of microcantilever sensors , 2001 .

[17]  Javier Tamayo,et al.  Piconewton regime dynamic force microscopy in liquid , 2000 .

[18]  Gil U. Lee,et al.  A high-sensitivity micromachined biosensor , 1997, Proc. IEEE.

[19]  J. Thaysen,et al.  Environmental sensors based on micromachined cantilevers with integrated read-out , 2000, Ultramicroscopy.

[20]  M. Miles,et al.  Chemical sensors and biosensors in liquid environment based on microcantilevers with amplified quality factor. , 2001, Ultramicroscopy.

[21]  Thomas Thundat,et al.  Adsorption-induced surface stress and its effects on resonance frequency of microcantilevers , 1995 .

[22]  Masayoshi Esashi,et al.  Investigating surface stress: Surface loss in ultrathin single-crystal silicon cantilevers , 2001 .

[23]  H Schindler,et al.  Detection and localization of individual antibody-antigen recognition events by atomic force microscopy. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  M. Miles,et al.  High-Q dynamic force microscopy in liquid and its application to living cells. , 2001, Biophysical journal.

[25]  Roberto Raiteri,et al.  Sensing of biological substances based on the bending of microfabricated cantilevers , 1999 .

[26]  Analysis of amplification of thermal vibrations of a microcantilever , 2001 .

[27]  H. Gaub,et al.  Adhesion forces between individual ligand-receptor pairs. , 1994, Science.

[28]  Nabil Ahmed,et al.  Measurement of solution viscosity by atomic force microscopy , 2001 .

[29]  Jerome Mertz,et al.  Regulation of a microcantilever response by force feedback , 1993 .

[30]  Paul K. Hansma,et al.  Studies of vibrating atomic force microscope cantilevers in liquid , 1996 .

[31]  Harald Fuchs,et al.  Analysis of the interaction mechanisms in dynamic mode SFM by means of experimental data and computer simulation , 1998 .