Determinative role of ring size and substituents in highly selective synthesis of functionalized bicyclic guanidine and tetra substituted thiophene derivatives based on salt adducts afforded by cyclic thioureas and ketene dithioacetal

[1]  M. Soural,et al.  Synthetic Strategies for Preparing Bicyclic Guanidines , 2015 .

[2]  G. Damonte,et al.  Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones. , 2013, European journal of medicinal chemistry.

[3]  Isamu Shiina,et al.  (R)-(+)-N-methylbenzoguanidine ((R)-NMBG) catalyzed kinetic resolution of racemic secondary benzylic alcohols with free carboxylic acids by asymmetric esterification. , 2011, Organic & biomolecular chemistry.

[4]  Choon‐Hong Tan,et al.  Mechanistic considerations of guanidine-catalyzed reactions. , 2011, Chemical communications.

[5]  N. Sach,et al.  Development of Scalable Syntheses of Selective PI3K inhibitors , 2011 .

[6]  M. P. Coles,et al.  Bicyclic-guanidines, -guanidinates and -guanidinium salts: wide ranging applications from a simple family of molecules. , 2009, Chemical communications.

[7]  E. Corey,et al.  NAME REACTIONS IN HETEROCYCLIC CHEMISTRY , 2009 .

[8]  M. Negri,et al.  Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). , 2008, Journal of medicinal chemistry.

[9]  M. H. Kossuga,et al.  The chemistry and biology of organic guanidine derivatives. , 2008, Natural product reports.

[10]  Clemencia Pinilla,et al.  Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. , 2008, Bioorganic & medicinal chemistry.

[11]  P. Gallant,et al.  Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity. , 2008, Journal of medicinal chemistry.

[12]  F. Hadizadeh,et al.  Sono-synthesis of imidazolidine-2-thione as a base compound of some pharmaceutical products. , 2008, Ultrasonics sonochemistry.

[13]  M. Terada,et al.  Aza-Henry reaction of ketimines catalyzed by guanidine and phosphazene bases , 2007 .

[14]  I. Nakamura,et al.  Gold-catalyzed intramolecular carbothiolation of alkynes: synthesis of 2,3-disubstituted benzothiophenes from (alpha-alkoxy alkyl) (ortho-alkynyl phenyl) sulfides. , 2006, Angewandte Chemie.

[15]  T. Soós,et al.  Thionation using fluorous Lawesson's reagent. , 2006, Organic letters.

[16]  H. Kung,et al.  Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. , 2006, Bioorganic & medicinal chemistry letters.

[17]  H. Padh,et al.  Tetra substituted thiophenes as anti-inflammatory agents: exploitation of analogue-based drug design. , 2005, Bioorganic & medicinal chemistry.

[18]  M. Taddei,et al.  Microwave‐Assisted Paal–Knorr Reaction – Three‐Step Regiocontrolled Synthesis of Polysubstituted Furans, Pyrroles and Thiophenes , 2005 .

[19]  Weiping Ye,et al.  1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions , 2005 .

[20]  F. Moghaddam,et al.  An efficient and facile one-step synthesis of highly substituted thiophenes , 2004 .

[21]  T. Swager,et al.  Charge-specific interactions in segmented conducting polymers: an approach to selective ionoresistive responses. , 2004, Angewandte Chemie.

[22]  Tony J. You,et al.  Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist. , 2004, Journal of medicinal chemistry.

[23]  T. Ishikawa,et al.  Modified guanidines as chiral auxiliaries. , 2002, Chemistry.

[24]  A. Da Settimo,et al.  Synthesis, in vitro antiproliferative activity and DNA-interaction of benzimidazoquinazoline derivatives as potential anti-tumor agents. , 2001, Farmaco.

[25]  R. Baruchello,et al.  1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD), 7-methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD): three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems , 2000 .

[26]  L. Battistini,et al.  The synthetic utility of furan-, pyrrole- and thiophene-based 2-silyloxy dienes , 2000 .

[27]  E. Corey,et al.  Enantioselective synthesis of alpha-amino nitriles from N-benzhydryl imines and HCN with a chiral bicyclic guanidine as catalyst. , 1999, Organic letters.

[28]  J. Roncali.  Synthetic Principles for Bandgap Control in Linear pi-Conjugated Systems. , 1997, Chemical reviews.

[29]  Francis A. Carey,et al.  Advanced Organic Chemistry, Part B , 1990 .

[30]  M. Venuti,et al.  Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856). , 1988, Journal of medicinal chemistry.

[31]  P. J. Taylor,et al.  Conformational and tautomeric studies of acylguanidines. Part 1. Synthesis, ultraviolet spectroscopy, tautomeric preference, and site of protonation in some model compounds , 1985 .

[32]  R. Gompper,et al.  Carbonsäurederivate, V. Substituierte Dithiocarbonsäuren und Ketenmercaptale , 1962 .

[33]  A. M. Schreiber,et al.  The 1,2-Dithiolium Cation. A New Pseudoaromatic System. II. Condensation of Phenyl-1,2-dithiolium Salts with Tertiary Aromatic Amines , 1962 .

[34]  C. Kelber.  Über die Einwirkung von Schwefelkohlenstoff und Ätzkali auf Acetophenon , 1910 .