Potentiation by histaminase inhibitors of the effects of histamine on the rectal temperature in the unanaesthetized guinea pig.

Summary. 1   The effects of subcutaneous injections of histamine on the rectal temperature of guinea-pigs were potentiated by amino-guanidine and 2-methyl-4-amino-5-methylaminopyrimidine, two histaminase inhibitors. 2  The histaminase inhibitors did not increase the response of the rectal temperature to two “histamine analogues”, which have pharmacological effects resembling those of histamine. The “histamine analogues” used are resistant to histaminase in vitro. I am grateful to dr. H. O. Schild for advice on the statistical treatment of the data. The technical assistance given by Miss M.-B. Johansson was highly appreciated. This investigation was aided by a grant from the Medical Faculty, University of Lund.