The effect of epidural placement in patients after blunt thoracic trauma

BACKGROUND In studies of trauma patients with rib fractures, conclusions on the benefits derived from epidural analgesia are inconsistent. The purpose of this study was to further evaluate placement and efficacy of epidural analgesia nationwide. METHODS This was a retrospective cohort study of prospectively gathered data from the National Study on Cost and Outcomes of Trauma database, a multisite prospective study of injured patients aged 18 years to 84 years. Patients were treated at 69 participating hospitals (18 Level I trauma centers and 51 nontrauma centers) across the United States. Our analysis was limited to patients with a blunt mechanism of injury and a thoracic maximum Abbreviated Injury Scale (MAXAIS) score of 2 or greater. Excluded were patients who were not potential candidates for epidural placement, such as patients with significant head and spine injuries (head MAXAIS score > 2 or spine MAXAIS score > 2), significant neurologic impairment (best motor Glasgow Coma Scale [GCS] score < 4), unstable pelvic fractures, coagulopathy, or those who died within 48 hours. RESULTS The National Study on Cost and Outcomes of Trauma database contains 5,043 patients, of whom 836 (16.5%) were identified as potential candidates for epidural placement. Of patients included in the study, 100 patients (12%) had epidural catheters placed. The likelihood of epidural catheter placement was significantly higher in trauma centers as compared with nontrauma centers (adjusted odds ratio, 3.06; 95% confidence interval [CI] 1.80–5.22). In the epidural group compared with those not receiving a catheter, the adjusted (including trauma center status) odds of death in patients with three or more rib fractures at 30, 90, and 365 days was 0.08 (95% CI, 0.01–0.43), 0.09 (95% CI, 0.02–0.42), and 0.12 (95% CI, 0.04–0.42), respectively. CONCLUSION Trauma centers are more likely to place epidural catheter in patients with rib fractures. In this multicenter study, epidural catheter placement was associated with a significantly decreased risk of dying in patients with blunt thoracic injury of three or more rib fractures. LEVEL OF EVIDENCE Therapeutic study, level II.

[1]  M. Anitescu,et al.  Opioid‐Free Perioperative Analgesia for Hemicolectomy in a Patient With Opioid‐Induced Delirium: A Case Report and Review of the Analgesic Efficacy of the Alpha‐2 Agonist Agents , 2012, Pain practice : the official journal of World Institute of Pain.

[2]  M. Knudson,et al.  Epidural analgesia for blunt thoracic injury--which patients benefit most? , 2012, Injury.

[3]  L. Critchley,et al.  Acute pain management of patients with multiple fractured ribs: a focus on regional techniques , 2011, Current Opinion in Critical Care.

[4]  K. Inaba,et al.  Sympathetic hyperactivity after traumatic brain injury and the role of beta-blocker therapy. , 2010, The Journal of trauma.

[5]  S. Norwood,et al.  Ventilator-associated pneumonia is more common and of less consequence in trauma patients compared with other critically ill patients. , 2010, The Journal of trauma.

[6]  Justin B Dimick,et al.  Introduction to propensity scores: A case study on the comparative effectiveness of laparoscopic vs open appendectomy. , 2010, Archives of surgery.

[7]  K. Davis,et al.  Factors associated with survival following blunt chest trauma in older patients: results from a large regional trauma cooperative. , 2010, Archives of surgery.

[8]  E. Mackenzie,et al.  Complication rates among trauma centers. , 2009, Journal of the American College of Surgeons.

[9]  A. Turgeon,et al.  Effect of epidural analgesia in patients with traumatic rib fractures: a systematic review and meta-analysis of randomized controlled trials , 2009, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[10]  R. D'Agostino Propensity Scores in Cardiovascular Research , 2007, Circulation.

[11]  C. Cocanour,et al.  A multidisciplinary clinical pathway decreases rib fracture-associated infectious morbidity and mortality in high-risk trauma patients. , 2006, American journal of surgery.

[12]  R. Ferrer,et al.  Risk and prognostic factors of ventilator-associated pneumonia in trauma patients , 2006, Critical care medicine.

[13]  Daniel O Scharfstein,et al.  A national evaluation of the effect of trauma-center care on mortality. , 2006, The New England journal of medicine.

[14]  F. Luchette,et al.  Pain management guidelines for blunt thoracic trauma. , 2005, The Journal of trauma.

[15]  R. Maier,et al.  Effect of patient load on trauma outcomes in a Level I trauma center. , 2005, The Journal of trauma.

[16]  R. Gamelli,et al.  Half-a-dozen ribs: the breakpoint for mortality. , 2005, Surgery.

[17]  J. Hata,et al.  Regional analgesia in the critically ill , 2005, Critical care medicine.

[18]  Alicia N. Kieninger,et al.  Epidural versus intravenous pain control in elderly patients with rib fractures. , 2005, American journal of surgery.

[19]  Donald B Rubin,et al.  On principles for modeling propensity scores in medical research , 2004, Pharmacoepidemiology and drug safety.

[20]  E. Bulger,et al.  Epidural analgesia improves outcome after multiple rib fractures. , 2004, Surgery.

[21]  R. Maier,et al.  A comparison of prehospital and hospital data in trauma patients. , 2004, The Journal of trauma.

[22]  A. Ho,et al.  Acute pain management of patients with multiple fractured ribs. , 2003, Journal of Trauma.

[23]  Philip D Lumb,et al.  Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. , 2002, Critical care medicine.

[24]  C N Mock,et al.  Rib fractures in the elderly. , 2000, The Journal of trauma.

[25]  C. Mann,et al.  Comparison of Intravenous or Epidural Patient-controlled Analgesia in the Elderly after Major Abdominal Surgery , 2000, Anesthesiology.

[26]  Christopher L. Wu,et al.  Thoracic epidural analgesia versus intravenous patient-controlled analgesia for the treatment of rib fracture pain after motor vehicle crash. , 1999, The Journal of trauma.

[27]  J. Fischer,et al.  Prospective, randomized comparison of epidural versus parenteral opioid analgesia in thoracic trauma. , 1999, Annals of surgery.

[28]  Donald Rubin,et al.  Estimating Causal Effects from Large Data Sets Using Propensity Scores , 1997, Annals of Internal Medicine.

[29]  D. Ziegler,et al.  The morbidity and mortality of rib fractures. , 1994, The Journal of trauma.

[30]  D B Rubin,et al.  Multiple imputation in health-care databases: an overview and some applications. , 1991, Statistics in medicine.

[31]  D. Hoyt,et al.  Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures. , 1991, The Journal of trauma.

[32]  E. Mackenzie,et al.  Three or more rib fractures as an indicator for transfer to a Level I trauma center: a population-based study. , 1990, The Journal of trauma.

[33]  D. Wisner A stepwise logistic regression analysis of factors affecting morbidity and mortality after thoracic trauma: effect of epidural analgesia. , 1989, The Journal of trauma.

[34]  L. Worthley Thoracic epidural in the management of chest trauma , 1985, Intensive Care Medicine.

[35]  C. Schwab,et al.  Blunt chest trauma in the elderly. , 1985, The American surgeon.

[36]  P. Wade,et al.  Sedation in the Intensive-care Unit , 1984, The Lancet.

[37]  E. Letang,et al.  Indications and Surgical Treatment of the Traumatic Flail Chest Syndrome. An Original Technique , 1982, The Thoracic and cardiovascular surgeon.

[38]  F. Rivara,et al.  Patient outcomes in academic medical centers: influence of fellowship programs and in-house on-call attending surgeon. , 2003, Archives of surgery.