Gaps in Penrose's toiling

Using the Godel Incompleteness Result for leverage, Roger Penrose has argued that the mechanism for consciousness involves quantum gravitational phenomena, acting through microtubules in neurons. We show that this hypothesis is implausible. First, the Godel Result does not imply that human thought is in fact non algorithmic. Second, whether or not non algorithmic quantum gravitational phenomena actually exist, and if they did how that could conceivably implicate microtubules, and if microtubules were involved, how that could conceivably implicate consciousness, is entirely speculative. Third, cytoplasmic ions such as calcium and sodium are almost certainly present in the microtubule pore, barring the quantum mechanical effects Penrose envisages. Finally, physiological evidence indicates that consciousness does not directly depend on microtubule properties in any case, rendering doubtful any theory according to which consciousness is generated in the microtubules.

[1]  B. MacWhinney,et al.  Functionalism and the competition model , 1989 .

[2]  D. Bloor,et al.  Knowledge and Social Imagery , 1977 .

[3]  K. Pribram,et al.  Quantum optical coherence in cytoskeletal microtubules: implications for brain function. , 1994, Bio Systems.

[4]  W. Sossin,et al.  Cellular and molecular biology of neuropeptide processing and packaging , 1989, Neuron.

[5]  R. Llinás,et al.  Coherent 40-Hz oscillation characterizes dream state in humans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[6]  T. J. Walsh,et al.  Ganglioside AGF2 prevents the cognitive impairments and cholinergic cell loss following intraventricular colchicine , 1991, Experimental Neurology.

[7]  J. Conner,et al.  Distribution of nerve growth factor‐like immunoreactive neurons in the adult rat brain following colchicine treatment , 1992, The Journal of comparative neurology.

[8]  L. Goodman,et al.  The Pharmacological Basis of Therapeutics , 1976 .

[9]  E. Bennett,et al.  Uptake of [3H]colchicine into brain and liver of mouse, rat, and chick , 1980, Pharmacology Biochemistry and Behavior.

[10]  Michael Barr,et al.  The Emperor's New Mind , 1989 .

[11]  N. Logothetis,et al.  Neuronal correlates of subjective visual perception. , 1989, Science.

[12]  R. Llinás,et al.  Of dreaming and wakefulness , 1991, Neuroscience.

[13]  C. Stevens,et al.  Changes in reliability of synaptic function as a mechanism for plasticity , 1994, Nature.

[14]  Per Roland,et al.  The engine of reason, the seat of the soul , 1996 .

[15]  Judith E. Dayhoff,et al.  Models for molecular computation: conformational automata in the cytoskeleton , 1992, Computer.

[16]  Hilary Putnam,et al.  Philosophy of mathematics : selected readings , 1984 .

[17]  V. Tennyson The Fine Structure of the Nervous System. , 1970 .

[18]  Michael Dummett,et al.  The logical basis of metaphysics , 1991 .

[19]  Willard Van Orman Quine,et al.  Philosophy of Logic. , 1988 .

[20]  I. Lakatos PROOFS AND REFUTATIONS (I)*† , 1963, The British Journal for the Philosophy of Science.

[21]  DiVincenzo,et al.  Growing perfect quasicrystals. , 1988, Physical review letters.

[22]  F. Crick The Astonishing Hypothesis , 1994 .

[23]  R C Watt,et al.  Information processing in microtubules. , 1982, Journal of theoretical biology.

[24]  Images and subjectivity: Neurobiological trials and tribulations , 1996 .

[25]  Carver Mead,et al.  Analog VLSI and neural systems , 1989 .

[26]  T. Sejnowski,et al.  Thalamocortical oscillations in the sleeping and aroused brain. , 1993, Science.

[27]  R. Penrose,et al.  Shadows of the Mind , 1994 .

[28]  Philip Kitcher,et al.  The nature of mathematical knowledge , 1985 .

[29]  Michael I. Jordan Serial Order: A Parallel Distributed Processing Approach , 1997 .

[30]  A. Heyting,et al.  Intuitionism: An introduction , 1956 .

[31]  J. Bogen,et al.  On the Neurophysiology of Consciousness: 1. An Overview , 1995, Consciousness and Cognition.

[32]  Stuart R. Hameroff,et al.  QUANTUM COHERENCE IN MICROTUBULES: A NEURAL BASIS FOR EMERGENT CONSCIOUSNESS? 1 , 1994 .

[33]  Terrence J. Sejnowski,et al.  The Computational Brain , 1996, Artif. Intell..

[34]  G. Bensimon,et al.  Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats , 1991, Pharmacology Biochemistry and Behavior.

[35]  W. R. Lieb,et al.  Molecular and cellular mechanisms of general anaesthesia , 1994, Nature.