A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

[1]  H. Lamb,et al.  The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity , 2021, International Journal of Obesity.

[2]  P. Schrauwen,et al.  Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. , 2020, The Journal of clinical endocrinology and metabolism.

[3]  J. Borén,et al.  Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance , 2020, Nature Communications.

[4]  Congye Li,et al.  PP2Cm overexpression alleviates MI/R injury mediated by a BCAA catabolism defect and oxidative stress in diabetic mice. , 2019, European journal of pharmacology.

[5]  D. Wishart,et al.  Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure , 2019, Cardiovascular Diabetology.

[6]  Zhaoping Li,et al.  Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance , 2019, Diabetes.

[7]  D. Chuang,et al.  Therapeutic Effect of Targeting Branched‐Chain Amino Acid Catabolic Flux in Pressure‐Overload Induced Heart Failure , 2019, Journal of the American Heart Association.

[8]  E. White,et al.  Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. , 2019, Cell metabolism.

[9]  Michael Neinast,et al.  Branched Chain Amino Acids in Metabolic Disease , 2018, Current Diabetes Reports.

[10]  D. Chuang,et al.  The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. , 2018, Cell metabolism.

[11]  M. Laakso,et al.  Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes , 2017, EBioMedicine.

[12]  Joshua D. Rabinowitz,et al.  Metabolite Spectral Accuracy on Orbitraps. , 2017, Analytical chemistry.

[13]  S. Klein,et al.  Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance , 2017, Diabetes.

[14]  R. Tian,et al.  Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury. , 2017, Cell metabolism.

[15]  Mee-Sup Yoon.  The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism , 2016, Nutrients.

[16]  J. Rabinowitz,et al.  A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance , 2016, Nature Medicine.

[17]  K. Nair,et al.  Effect of insulin sensitizer therapy on amino acids and their metabolites. , 2015, Metabolism: clinical and experimental.

[18]  C. Lynch,et al.  Branched-chain amino acids in metabolic signalling and insulin resistance , 2014, Nature Reviews Endocrinology.

[19]  Mahim Jain,et al.  Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders. , 2014, Molecular genetics and metabolism.

[20]  D. Chuang,et al.  Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase* , 2014, The Journal of Biological Chemistry.

[21]  Heather A Zimmerman,et al.  Adipose transplant for inborn errors of branched chain amino acid metabolism in mice. , 2013, Molecular genetics and metabolism.

[22]  F. Haj,et al.  Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. , 2013, American journal of physiology. Endocrinology and metabolism.

[23]  Terho Lehtimäki,et al.  Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults , 2013, Diabetes Care.

[24]  Ruth C. R. Meex,et al.  Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus , 2013, PloS one.

[25]  A. Peters,et al.  Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach , 2013, Diabetes.

[26]  J. Calviño,et al.  Insulin resistance and the metabolism of branched-chain amino acids in humans , 2012, Amino Acids.

[27]  M. Roden,et al.  The role of mitochondria in insulin resistance and type 2 diabetes mellitus , 2012, Nature Reviews Endocrinology.

[28]  S. Adams.  Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. , 2011, Advances in nutrition.

[29]  V. Mootha,et al.  Metabolite profiles and the risk of developing diabetes , 2011, Nature Medicine.

[30]  Joshua D Rabinowitz,et al.  Metabolomic analysis and visualization engine for LC-MS data. , 2010, Analytical chemistry.

[31]  P. Schrauwen,et al.  Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals , 2010, Diabetologia.

[32]  K. Hayashi,et al.  Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. , 2010, Biochemical and biophysical research communications.

[33]  Ruth C. R. Meex,et al.  Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity , 2009, Diabetes.

[34]  Svati H Shah,et al.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. , 2009, Cell metabolism.

[35]  Pengxiang She,et al.  Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. , 2007, American journal of physiology. Endocrinology and metabolism.

[36]  Yu Li,et al.  Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance , 2007, Proceedings of the National Academy of Sciences.

[37]  M. Roden,et al.  The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man , 2007, Diabetes.

[38]  G. Thomas,et al.  Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. , 2006, Cell metabolism.

[39]  A. Klip,et al.  Tissue-specific roles of IRS proteins in insulin signaling and glucose transport , 2006, Trends in Endocrinology & Metabolism.

[40]  E. Moser,et al.  1H NMR relaxation times of skeletal muscle metabolites at 3 T , 2004, Magnetic Resonance Materials in Physics, Biology and Medicine.

[41]  S. Kahn,et al.  The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes , 2003, Diabetologia.

[42]  Robert A. Harris,et al.  Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain α-keto acid dehydrogenase kinase , 2001, Current opinion in clinical nutrition and metabolic care.

[43]  J. Romijn,et al.  The quantification of gluconeogenesis in healthy men by (2)H2O and [2-(13)C]glycerol yields different results: rates of gluconeogenesis in healthy men measured with (2)H2O are higher than those measured with [2-(13)C]glycerol. , 2001, The Journal of clinical endocrinology and metabolism.

[44]  R. Harris,et al.  A molecular model of human branched-chain amino acid metabolism. , 1998, The American journal of clinical nutrition.

[45]  A. Kuznetsov,et al.  Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers. , 1987, Biochimica et biophysica acta.

[46]  M. Brosnan,et al.  Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate. , 1986, The Biochemical journal.

[47]  K. Frayn,et al.  Calculation of substrate oxidation rates in vivo from gaseous exchange. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[48]  T. Singer,et al.  Inactivation of the 2-ketoglutarate and pyruvate dehydrogenase complexes of beef heart by branched chain keto acids. , 1983, The Journal of biological chemistry.

[49]  E Hultman,et al.  Diet, muscle glycogen and physical performance. , 1967, Acta physiologica Scandinavica.

[50]  R. Steele,et al.  INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT * , 1959, Annals of the New York Academy of Sciences.

[51]  J. B. Weir.  New methods for calculating metabolic rate with special reference to protein metabolism , 1949, The Journal of physiology.

[52]  J. Wildberger,et al.  Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. , 2015, The American journal of clinical nutrition.

[53]  M. Westerterp-Plantenga,et al.  Measurement of longitudinal changes in body composition during weight loss and maintenance in overweight and obese subjects using air-displacement plethysmography in comparison with the deuterium dilution technique , 2011, International Journal of Obesity.

[54]  R. Harris,et al.  Regulation of branched-chain alpha-keto acid dehydrogenase kinase expression in rat liver. , 2001, The Journal of nutrition.

[55]  K. M. Popov,et al.  Branched-chain alpha-keto acid dehydrogenase kinase. , 2000, Methods in enzymology.

[56]  J. B. Weir.  New methods for calculating metabolic rate with special reference to protein metabolism. 1949. , 1990, Nutrition.