Mechanosensitive mTORC1 signaling maintains lymphatic valves

Saygili Demir, Sabine et al. identify proliferating valve sinus endothelial cells as a main source for repair of postnatal lymphatic vessels. The process is driven by mechanosensitive mTORC1 activation, which controls both proliferation and protein synthesis. These findings provide a mechanistic explanation for increased incidence of lymphedema in rapamycin-treated patients.