Clinical trials in cardiovascular disease : a companion to Braunwald's heart disease
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Part I: Methodology. Contribution of Basic Research, Observational Epidemiology and Randomized Trials. Methodology of Randomized Trials. Special Features of Primary Prevention Vs. High-Risk Vs. Secondary Prevention Trials. Strengths and Limitations of Large, Simple Trials Vs. Small Trials. Principles of Data Monitoring Boards in Trials. Meta-Analysis. Part Ii: Treatment Trials. Aspirin and Heparin. Thrombolytic Therapy. Beta-Blockers. Ace Inhibitors. Calcium Channel Blockers. Magnesium. Nitrates. Direct Thrombin Inhibitors. Glycoprotein Iib/Iiia Receptor Inhibitors. Primary and Rescue Angioplasty. Lipid-Lowering Agents. Anti-Arrhythmia Therapy in Ischemic Heart Disease. Anti-Arrhythmia Therapy in Atrial Fibrillation. Anti-Platelet Agents and Anticoagulation in Ischemic Heart Disease. Anti-Platelet Agents and Anticoagulation in Atrial Fibrillation. Angioplasty and Bypass Surgery. Exercise. Congestive Heart Failure. Part Iii: Prevention Trials: Cholesterol Reduction. Blood Pressure Reduction. Smoking Cessation. Weight Reduction/Exercise. Stress Reduction. Aspirin Prophylaxis. Postmenopausal Hormone Replacement Therapy. Antioxidant Vitamins. Other Dietary Interventions. Multiple Risk Factor Intervention Trials. Prevention Strategies: Population-Based, Community-Based, Worksite, Targeted High Risk Subgroups. Part Iv: Future Needs.