A Problematic Case of Unclassified Multicystic Biliary Tumor with Adenofibroma Features

Biliary adenofibroma (BFA) was first described by Tsui et al. (1). Since then, few cases of BFA of the liver have been reported in the literature (1-8). It is characterized by tubulocystic proliferation of variable-sized neoplastic ducts embedded in abundant fibrous stroma. The typical case of biliary adenofibroma shows a non-mucin secreting and apocrine-like epithelium that expresses biliary cytokeratins (CK7, CK19), suggesting a bile duct origin (1,6). In this report, we describe a case of biliary multicystic tumor with adenofibroma features, which did not fit any current classification of biliary tumor.