Sevoflurane anesthesia during pregnancy in mice induces hearing impairment in the offspring

Introduction: Exposure to gamma-aminobutyric acid-mimetics and N-methyl- d -aspartate-receptor antagonists during pregnancy may lead to hearing loss and long-term behavioral abnormalities in the offspring. The purpose of this study was to explore the association between prenatal exposure to sevoflurane (SEV) anesthesia and hearing impairment in mice. Materials and methods: On gestational day 15, pregnant Kunming mice were exposed for 2 hours to 2.5% SEV plus 100% oxygen (anesthesia group) or 100% oxygen alone (control group). Results: During auditory brainstem response testing on P30, offspring of the anesthesia group mice exhibited higher hearing thresholds at 8, 16, 24, and 32 kHz; longer peak latency of wave II at all four frequencies; and longer interpeak latencies from waves II to V at 16, 24, and 32 kHz, compared to the control offspring. Caspase-3, iNOS, and COX-2 activation occurred in the fetal cochlea of the anesthesia group. Mitochondrial swelling was observed in the anesthesia group offspring at P1 and P15. Conclusion: Our results suggest that SEV exposure during pregnancy may cause detrimental effects on the developing auditory system.

[1]  Jian Wang,et al.  BNIP3/Bcl-2-mediated apoptosis induced by cyclic tensile stretch in human cartilage endplate-derived stem cells , 2017, Experimental and therapeutic medicine.

[2]  M. Ji,et al.  Neurobehavioural abnormalities induced by repeated exposure of neonatal rats to sevoflurane can be aggravated by social isolation and enrichment deprivation initiated after exposure to the anaesthetic. , 2015, British journal of anaesthesia.

[3]  N. Roewer,et al.  Sevoflurane-Sulfobutylether-β-Cyclodextrin Complex: Preparation, Characterization, Cellular Toxicity, Molecular Modeling and Blood-Brain Barrier Transport Studies , 2015, Molecules.

[4]  Shan Sun,et al.  In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period , 2014, Front. Cell. Neurosci..

[5]  Yiying Zhang,et al.  Sevoflurane Anesthesia in Pregnant Mice Induces Neurotoxicity in Fetal and Offspring Mice , 2013, Anesthesiology.

[6]  M. Baxter,et al.  Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment , 2013, Anesthesiology.

[7]  Luigi Ferrucci,et al.  Hearing loss and cognitive decline in older adults: questions and answers , 2014, Aging Clinical and Experimental Research.

[8]  Y. He,et al.  Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death , 2013, Cell Death and Disease.

[9]  G. Housley,et al.  Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse , 2012, Hearing Research.

[10]  E. Marcantonio,et al.  Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory , 2012, Annals of neurology.

[11]  P. Flood,et al.  Anaesthetic considerations for non-obstetric surgery during pregnancy. , 2011, British journal of anaesthesia.

[12]  Feng Zhai,et al.  The relationship between age-related hearing loss and synaptic changes in the hippocampus of C57BL/6J mice , 2011, Experimental Gerontology.

[13]  A. Palanisamy,et al.  Rats Exposed to Isoflurane In Utero during Early Gestation Are Behaviorally Abnormal as Adults , 2011, Anesthesiology.

[14]  R. Salvi,et al.  Noise trauma impairs neurogenesis in the rat hippocampus , 2010, Neuroscience.

[15]  H. C. Stronks,et al.  Effects of isoflurane on auditory evoked potentials in the cochlea and brainstem of guinea pigs , 2010, Hearing Research.

[16]  Xu Wu,et al.  The Mitochondrial Pathway of Anesthetic Isoflurane-induced Apoptosis* , 2009, The Journal of Biological Chemistry.

[17]  J. Marks,et al.  Isoflurane inhibits the neurotransmitter release machinery. , 2009, Journal of neurophysiology.

[18]  E. Marcantonio,et al.  The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. , 2009, Archives of neurology.

[19]  Anders Fredriksson,et al.  Neonatal Exposure to a Combination of N-Methyl-d-aspartate and &ggr;-Aminobutyric Acid Type A Receptor Anesthetic Agents Potentiates Apoptotic Neurodegeneration and Persistent Behavioral Deficits , 2007, Anesthesiology.

[20]  H. Riechelmann,et al.  Cumulative lifelong alcohol consumption alters auditory brainstem potentials. , 2004, Alcoholism, clinical and experimental research.

[21]  A. Legatt.  Mechanisms of Intraoperative Brainstem Auditory Evoked Potential Changes , 2002, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[22]  A. Streissguth,et al.  Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. , 2000, Seminars in clinical neuropsychiatry.

[23]  J. Kaltenbach,et al.  Hearing, speech, language, and vestibular disorders in the fetal alcohol syndrome: a literature review. , 1997, Alcoholism, clinical and experimental research.

[24]  P. Baltes,et al.  Emergence of a powerful connection between sensory and cognitive functions across the adult life span: a new window to the study of cognitive aging? , 1997, Psychology and aging.

[25]  P. Fried,et al.  Central auditory processing in school-age children prenatally exposed to cigarette smoke. , 1994, Neurotoxicology and teratology.

[26]  K. Sulik,et al.  Patterns of ethanol-induced cell death in the developing nervous system of mice; Neural fold states through the time of anterior neural tube closure , 1992, International Journal of Developmental Neuroscience.

[27]  M W Church,et al.  Sensorineural hearing loss as evidenced by the auditory brainstem response following prenatal cocaine exposure in the Long-Evans rat. , 1991, Teratology.

[28]  A. Lam,et al.  The Effects of Isoflurane and Isoflurane‐Nitrous Oxide Anesthesia on Brainstem Auditory Evoked Potentials in Humans , 1985, Anesthesia and analgesia.

[29]  D. Teele,et al.  Epidemiology of Otitis Media in Children , 1980, The Annals of otology, rhinology & laryngology. Supplement.

[30]  N Lewis,et al.  Otitis media and linguistic incompetence. , 1976, Archives of otolaryngology.

[31]  J. Olney,et al.  Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome , 2009, Neurotoxicity Research.

[32]  G. Plourde.  Auditory evoked potentials. , 2006, Best practice & research. Clinical anaesthesiology.

[33]  J. Jacobson,et al.  Teratogenic hearing loss. , 1995, Journal of the American Academy of Audiology.