Effects of individual and combined dietary weight loss and exercise interventions in postmenopausal women on adiponectin and leptin levels

Excess body weight and a sedentary lifestyle are associated with the development of several diseases, including cardiovascular disease, diabetes and cancer in women. One proposed mechanism linking obesity to chronic diseases is an alteration in adipose‐derived adiponectin and leptin levels. We investigated the effects of 12‐month reduced calorie, weight loss and exercise interventions on adiponectin and leptin concentrations.

[1]  Angela Kong,et al.  Effect of Diet and Exercise, Alone or Combined, on Weight and Body Composition in Overweight‐to‐Obese Postmenopausal Women , 2012, Obesity.

[2]  H. Harwood,et al.  The adipocyte as an endocrine organ in the regulation of metabolic homeostasis , 2012, Neuropharmacology.

[3]  D. D’Alessio,et al.  Adiponectin Changes in Relation to the Macronutrient Composition of a Weight‐Loss Diet , 2011, Obesity.

[4]  C. Ulrich,et al.  Dietary weight loss and exercise effects on insulin resistance in postmenopausal women. , 2011, American journal of preventive medicine.

[5]  Merlin C. Thomas,et al.  Serum adiponectin concentration is a positive predictor of all‐cause and cardiovascular mortality in type 1 diabetes , 2011, Journal of internal medicine.

[6]  A. Feoli,et al.  Effect of diet on adiponectin levels in blood. , 2011, Nutrition reviews.

[7]  J. Elmquist,et al.  Sixteen years and counting: an update on leptin in energy balance. , 2011, The Journal of clinical investigation.

[8]  R. Rabasa-Lhoret,et al.  Improvement in insulin sensitivity by weight loss does not affect hyperinsulinemia-mediated reduction in total and high molecular weight adiponectin: a MONET study. , 2011, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[9]  Heather K. Neilson,et al.  Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women , 2011, Endocrine-related cancer.

[10]  T. Ploug,et al.  Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin. , 2010, The Journal of clinical endocrinology and metabolism.

[11]  C. Mantzoros,et al.  Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications , 2010, Annals of Internal Medicine.

[12]  E. Ford,et al.  Healthy living is the best revenge: findings from the European Prospective Investigation Into Cancer and Nutrition-Potsdam study. , 2009, Archives of internal medicine.

[13]  E. Ding,et al.  Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. , 2009, JAMA.

[14]  U. Broedl,et al.  Adipokines and Insulin Resistance , 2008, Molecular medicine.

[15]  G. Bray,et al.  Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program , 2008, Diabetes.

[16]  A. McTiernan,et al.  Mechanisms linking physical activity with cancer , 2008, Nature Reviews Cancer.

[17]  M. Zwahlen,et al.  Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies , 2008, The Lancet.

[18]  Maria A. Fiatarone Singh,et al.  Effects of Exercise on Adiponectin: A Systematic Review , 2008, Obesity.

[19]  Ken Williams,et al.  Which Obesity Index Best Explains Prevalence Differences in Type 2 Diabetes Mellitus? , 2007, Obesity.

[20]  C. Block,et al.  Mechanisms linking obesity with cardiovascular disease , 2006, Nature.

[21]  Kohjiro Ueki,et al.  Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. , 2006, The Journal of clinical investigation.

[22]  W. Willett,et al.  Plasma adiponectin concentrations and risk of incident breast cancer. , 2006, The Journal of clinical endocrinology and metabolism.

[23]  C. Mantzoros,et al.  Adiponectin and cancer: a systematic review , 2006, British Journal of Cancer.

[24]  Shinji Kihara,et al.  Adiponectin: a key adipocytokine in metabolic syndrome. , 2006, Clinical science.

[25]  W. Willett,et al.  Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. , 2005, Journal of the National Cancer Institute.

[26]  C. Ulrich,et al.  Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. , 2005, Obesity research.

[27]  J. Cerhan,et al.  Association of Gain and Loss of Weight before and after Menopause with Risk of Postmenopausal Breast Cancer in the Iowa Women's Health Study , 2005, Cancer Epidemiology Biomarkers & Prevention.

[28]  P. Scherer,et al.  Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome , 2005, Journal of internal medicine.

[29]  D. Rose,et al.  Obesity, adipocytokines, and insulin resistance in breast cancer , 2004, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[30]  C. Gutiérrez,et al.  Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. , 2004, Obesity research.

[31]  P. Stattin,et al.  Obesity and colon cancer: Does leptin provide a link? , 2004, International journal of cancer.

[32]  Karen C Johnson,et al.  Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. , 2003, Controlled clinical trials.

[33]  B. Nicklas,et al.  Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women , 2003, International Journal of Obesity.

[34]  R. Muniyappa,et al.  The diabetes prevention program , 2003, Current diabetes reports.

[35]  Graham M Lord,et al.  Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. , 2002, The Journal of clinical investigation.

[36]  S. Fowler,et al.  Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. , 2002, The New England journal of medicine.

[37]  P. Havel Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin , 2002, Current opinion in lipidology.

[38]  E. Bruckert,et al.  Variations in plasma soluble tumour necrosis factor receptors after diet‐induced weight loss in obesity , 2000, Diabetes, obesity & metabolism.

[39]  B Rosner,et al.  Waist circumference, waist:hip ratio, and risk of breast cancer in the Nurses' Health Study. , 1999, American journal of epidemiology.

[40]  J. Halaas,et al.  Leptin and the regulation of body weight in mammals , 1998, Nature.

[41]  C. Mantzoros,et al.  Adiponectin in insulin resistance: lessons from translational research. , 2010, The American journal of clinical nutrition.

[42]  E. Ponce,et al.  World Cancer Research Fund, American Institute for Cancer Research. Second Expert Report, Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. United Kingdom: WCRF/AICR, 2001 , 2009 .

[43]  廣畑 富雄,et al.  Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective , 2007 .

[44]  A. G. Shaper,et al.  Obesity and cardiovascular disease. , 1996, Ciba Foundation symposium.

[45]  T. Funahashi,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance , 2022 .

[46]  J. Drew Symposium 3: Obesity-related cancers Molecular mechanisms linking adipokines to obesity-related colon cancer: focus on leptin , 2022 .