Phenyl glycine incorporated glitazones as promising novel antidiabetic agents through PPARγ agonism: Design, synthesis and preclinical studies
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[1] A. Alshabi,et al. Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats , 2021, Saudi medical journal.
[2] S. Mandal,et al. Rational Design, Synthesis and Evaluation of Novel Rodanine Derivatives for Antihyperglycemic Activity , 2020, Polycyclic Aromatic Compounds.
[3] Qihua Zhu,et al. Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists. , 2020, Bioorganic & medicinal chemistry letters.
[4] V. Fokin,et al. Sulfuryl Fluoride Mediated Synthesis of Amides and Amidines from Ketoximes via Beckmann Rearrangement. , 2020, Chemistry.
[5] A. Justin,et al. Rational Design, Synthesis, and In Vitro Neuroprotective Evaluation of Novel Glitazones for PGC-1α Activation via PPAR-γ: a New Therapeutic Strategy for Neurodegenerative Disorders , 2019, Neurotoxicity Research.
[6] Hua-Li Qin,et al. Construction of Esters through Sulfuryl Fluoride (SO2F2) Mediated Dehydrative Coupling of Carboxylic Acids with Alcohols at Room Temperature , 2019, Synthesis.
[7] L. Adhikary,et al. Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies , 2018, Chemistry Central Journal.
[8] Binu Areekal,et al. Chronic kidney disease-prevalence and determinants among type 2 diabetes mellitus patients attending a primary care setting in central Kerala , 2018, International Journal Of Community Medicine And Public Health.
[9] Md. jahangir Alam,et al. Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole‐based 2,4‐thiazolidinedione derivatives as PPAR‐γ modulators , 2018, Archiv der Pharmazie.
[10] M. Noh,et al. 2-Formyl-komarovicine promotes adiponectin production in human mesenchymal stem cells through PPARγ partial agonism. , 2018, Bioorganic & medicinal chemistry.
[11] Cheng Luo,et al. Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. , 2017, Journal of medicinal chemistry.
[12] T. Tuttle,et al. A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling. , 2017, Organic & biomolecular chemistry.
[13] Xingcan Shen,et al. Poly(N-phenylglycine)-Based Nanoparticles as Highly Effective and Targeted Near-Infrared Photothermal Therapy/Photodynamic Therapeutic Agents for Malignant Melanoma. , 2017, Small.
[14] J. Rizzo,et al. Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation , 2016, Current opinion in ophthalmology.
[15] D. Staerk,et al. High-Resolution α-Glucosidase Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Antidiabetic Compounds in Eremanthus crotonoides (Asteraceae) , 2016, Molecules.
[16] Hui-Ding Xie,et al. An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors , 2015, International journal of molecular sciences.
[17] R. Süssmuth,et al. Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products. , 2015, Natural product reports.
[18] D. Bayliss,et al. Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes , 2015, Molecular metabolism.
[19] M. Talluri,et al. Design and study of a HPLC method for the simultaneous estimation of two anti-diabetic drugs using a statistical approach , 2014 .
[20] Zhe Zhang,et al. 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone promoted glucose uptake and imposed a paradoxical effect on adipocyte differentiation in 3T3-L1 cells. , 2014, Journal of agricultural and food chemistry.
[21] S. Um,et al. The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes. , 2012, Molecular nutrition & food research.
[22] Toshimasa Tanaka,et al. Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) γ Agonists. , 2012, Bioorganic & medicinal chemistry.
[23] T. Pal,et al. Development of safety profile evaluating pharmacokinetics, pharmacodynamics and toxicity of a combination of pioglitazone and olmesartan medoxomil in Wistar albino rats. , 2012, Regulatory toxicology and pharmacology : RTP.
[24] Andreas Prlic,et al. Pre-calculated protein structure alignments at the RCSB PDB website , 2010, Bioinform..
[25] Ruchi Tiwari,et al. Bioanalysis in drug discovery and development , 2010, Pharmaceutical methods.
[26] M. Yarmush,et al. Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα , 2010, PloS one.
[27] The Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies , 2010, The Lancet.
[28] Graeme Smith,et al. Bioanalytical method validation: notable points in the 2009 draft EMA Guideline and differences with the 2001 FDA Guidance. , 2010, Bioanalysis.
[29] F. K. Hansen,et al. New Phenylglycine‐Derived Primary Amine Organocatalysts for the Preparation of Optically Active Warfarin , 2009 .
[30] Jianhua Shen,et al. Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. , 2009, Bioorganic & medicinal chemistry.
[31] U. Singh,et al. Development and Applications of a Broad-Coverage, TR-FRET-Based Kinase Binding Assay Platform , 2009, Journal of biomolecular screening.
[32] Carsten Kutzner,et al. GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. , 2008, Journal of chemical theory and computation.
[33] M. Makishima,et al. Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome. , 2006, Bioorganic & medicinal chemistry.
[34] R. Liska,et al. Phenylglycine derivatives as coinitiators for the radical photopolymerization of acidic aqueous formulations , 2006 .
[35] T. Iga,et al. Sex differences in the pharmacokinetics of pioglitazone in rats. , 2003, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
[36] J Fraser Glickman,et al. A Comparison of ALPHAScreen, TR-FRET, and TRF as Assay Methods for FXR Nuclear Receptors , 2002, Journal of biomolecular screening.
[37] Berk Hess,et al. GROMACS 3.0: a package for molecular simulation and trajectory analysis , 2001 .
[38] B. Kaptein,et al. Asymmetric strecker synthesis of alpha-amino acids via a crystallization-induced asymmetric transformation using (R)-phenylglycine amide as chiral auxiliary. , 2001, Organic letters.
[39] Alexander P. Lyubartsev,et al. M.DynaMix – a scalable portable parallel MD simulation package for arbitrary molecular mixtures , 2000 .