Insulin-dependent diabetes mellitus and its animal models.

[1]  C. Janeway,et al.  Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library , 1999, Nature Medicine.

[2]  E. Unanue,et al.  The lack of consensus for I-A(g7)-peptide binding motifs: is there a requirement for anchor amino acid side chains? , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Atkinson,et al.  The NOD mouse model of type 1 diabetes: As good as it gets? , 1999, Nature Medicine.

[4]  R. Sherwin,et al.  Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells , 1999 .

[5]  Roep Bo Standardization of T-cell assays in Type I diabetes. Immunology of Diabetes Society T-cell Committee. , 1999 .

[6]  A. Jevnikar,et al.  Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. , 1999, Diabetes.

[7]  M. Juan,et al.  Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens. , 1998, Journal of immunology.

[8]  P. Bingley,et al.  Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. , 1998, Diabetes.

[9]  S. Baekkeskov,et al.  Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. , 1998, Diabetes.

[10]  D. Douek,et al.  Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. , 1998, International immunology.

[11]  D. Roopenian,et al.  Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[12]  D. Kioussis,et al.  Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. , 1998, The Journal of clinical investigation.

[13]  R. Sherwin,et al.  Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Mason,et al.  Intrathymic expression of genes involved in organ specific autoimmune disease. , 1998, Journal of autoimmunity.

[15]  Troy Krahl,et al.  Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry , 1998, Nature Medicine.

[16]  M. Rowley,et al.  Antibodies to ICA512/IA-2 in rodent models of IDDM. , 1998, Journal of autoimmunity.

[17]  M. Throsby,et al.  Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages. , 1998, Endocrinology.

[18]  A. Cooke,et al.  Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration. , 1998, Journal of autoimmunity.

[19]  B. Roep,et al.  Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain. , 1998, Journal of autoimmunity.

[20]  S. Virgiliis,et al.  T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[21]  E. Unanue,et al.  Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Atkinson,et al.  Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens , 1997, Diabetes.

[23]  P. Bingley,et al.  Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers , 1997, Diabetes.

[24]  C. David,et al.  T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice. , 1997, Human immunology.

[25]  D. Cohen,et al.  Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice. , 1997, The Journal of clinical investigation.

[26]  Kathleen M. Smith,et al.  Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. , 1997, International immunology.

[27]  K. Amano,et al.  CD8 cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid mice , 1997, Diabetologia.

[28]  L. Fugger,et al.  Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[29]  L. Wen,et al.  Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse , 1997, Diabetes.

[30]  J. Todd,et al.  Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus , 1997, Nature Genetics.

[31]  Camillo Ricordi,et al.  The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes , 1997, Nature Genetics.

[32]  L. Harrison,et al.  Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice , 1997, Diabetes.

[33]  A. Tobin,et al.  Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice , 1996, Nature Medicine.

[34]  L. Harrison,et al.  Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes , 1996, The Journal of experimental medicine.

[35]  J F Elliott,et al.  Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. , 1996, The Journal of clinical investigation.

[36]  M. Rowley,et al.  Lack of autoimmune serological reactions in rodent models of insulin dependent diabetes mellitus. , 1996, Journal of autoimmunity.

[37]  J. Hutton,et al.  Identification of the 37-kDa Antigen in IDDM as a Tyrosine Phosphatase-Like Protein (Phogrin) Related to IA-2 , 1996, Diabetes.

[38]  M. Solimena,et al.  ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. , 1996, The EMBO journal.

[39]  M. Atkinson,et al.  Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes , 1996, The Journal of experimental medicine.

[40]  D. Wegmann,et al.  Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  E. Unanue,et al.  The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. , 1996, Journal of immunology.

[42]  C. Janeway,et al.  CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells , 1996, The Journal of experimental medicine.

[43]  P. van Endert,et al.  Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes , 1995, The Journal of experimental medicine.

[44]  D. Wegmann,et al.  Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice , 1995, European journal of immunology.

[45]  M. A. Bowman,et al.  Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. , 1994, The Journal of clinical investigation.

[46]  E. Bonifacio,et al.  Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity , 1994, Diabetes.

[47]  T. Utsugi,et al.  Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice. , 1994, Journal of immunology.

[48]  B. Bergman,et al.  Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen , 1994, Diabetes.

[49]  S. Baekkeskov,et al.  Differential Expression of GAD65 and GAD67 in Human, Rat, and Mouse Pancreatic Islets , 1993, Diabetes.

[50]  A. Tobin,et al.  Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes , 1993, Nature.

[51]  R. Tisch,et al.  Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice , 1993, Nature.

[52]  C. Benoist,et al.  Following a diabetogenic T cell from genesis through pathogenesis , 1993, Cell.

[53]  O. Madsen,et al.  Differential Expression of Glutamic Acid Decarboxylase in Rat and Human Islets , 1993, Diabetes.

[54]  H. Weiner,et al.  Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. , 1991 .

[55]  S. Baekkeskov,et al.  Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase , 1990, Nature.

[56]  J. Palmer,et al.  Insulin antibodies in insulin-dependent diabetics before insulin treatment. , 1983, Science.

[57]  S. Baekkeskov,et al.  Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins , 1982, Nature.

[58]  F. Wong,et al.  GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice. , 1998, The Journal of clinical investigation.

[59]  J. Petersen,et al.  Treatment with GAD65 or BSA does not protect against diabetes in BB rats. , 1997, Autoimmunity.

[60]  P. Bougnères,et al.  Treatment of prediabetic patients with insulin: experience and future. European Prediabetes Study Group. , 1996, Hormone research.

[61]  H. Rammensee,et al.  Peptides naturally presented by MHC class I molecules. , 1993, Annual review of immunology.