Insulin-dependent diabetes mellitus and its animal models.
暂无分享,去创建一个
[1] C. Janeway,et al. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library , 1999, Nature Medicine.
[2] E. Unanue,et al. The lack of consensus for I-A(g7)-peptide binding motifs: is there a requirement for anchor amino acid side chains? , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[3] M. Atkinson,et al. The NOD mouse model of type 1 diabetes: As good as it gets? , 1999, Nature Medicine.
[4] R. Sherwin,et al. Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells , 1999 .
[5] Roep Bo. Standardization of T-cell assays in Type I diabetes. Immunology of Diabetes Society T-cell Committee. , 1999 .
[6] A. Jevnikar,et al. Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. , 1999, Diabetes.
[7] M. Juan,et al. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens. , 1998, Journal of immunology.
[8] P. Bingley,et al. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. , 1998, Diabetes.
[9] S. Baekkeskov,et al. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. , 1998, Diabetes.
[10] D. Douek,et al. Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice. , 1998, International immunology.
[11] D. Roopenian,et al. Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[12] D. Kioussis,et al. Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. , 1998, The Journal of clinical investigation.
[13] R. Sherwin,et al. Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[14] D. Mason,et al. Intrathymic expression of genes involved in organ specific autoimmune disease. , 1998, Journal of autoimmunity.
[15] Troy Krahl,et al. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry , 1998, Nature Medicine.
[16] M. Rowley,et al. Antibodies to ICA512/IA-2 in rodent models of IDDM. , 1998, Journal of autoimmunity.
[17] M. Throsby,et al. Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages. , 1998, Endocrinology.
[18] A. Cooke,et al. Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administration. , 1998, Journal of autoimmunity.
[19] B. Roep,et al. Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain. , 1998, Journal of autoimmunity.
[20] S. Virgiliis,et al. T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[21] E. Unanue,et al. Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[22] M. Atkinson,et al. Retardation or Acceleration of Diabetes in NOD/Lt Mice Mediated by Intrathymic Administration of Candidate β-Cell Antigens , 1997, Diabetes.
[23] P. Bingley,et al. Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers , 1997, Diabetes.
[24] C. David,et al. T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic mice. , 1997, Human immunology.
[25] D. Cohen,et al. Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice. , 1997, The Journal of clinical investigation.
[26] Kathleen M. Smith,et al. Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. , 1997, International immunology.
[27] K. Amano,et al. CD8 cytotoxic T-cell clone rapidly transfers autoimmune diabetes in very young NOD and MHC class I-compatible scid mice , 1997, Diabetologia.
[28] L. Fugger,et al. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[29] L. Wen,et al. Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse , 1997, Diabetes.
[30] J. Todd,et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus , 1997, Nature Genetics.
[31] Camillo Ricordi,et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes , 1997, Nature Genetics.
[32] L. Harrison,et al. Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice , 1997, Diabetes.
[33] A. Tobin,et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice , 1996, Nature Medicine.
[34] L. Harrison,et al. Aerosol Insulin Induces Regulatory CD8 γδ T Cells That Prevent Murine Insulin-dependent Diabetes , 1996, The Journal of experimental medicine.
[35] J F Elliott,et al. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. , 1996, The Journal of clinical investigation.
[36] M. Rowley,et al. Lack of autoimmune serological reactions in rodent models of insulin dependent diabetes mellitus. , 1996, Journal of autoimmunity.
[37] J. Hutton,et al. Identification of the 37-kDa Antigen in IDDM as a Tyrosine Phosphatase-Like Protein (Phogrin) Related to IA-2 , 1996, Diabetes.
[38] M. Solimena,et al. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. , 1996, The EMBO journal.
[39] M. Atkinson,et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes , 1996, The Journal of experimental medicine.
[40] D. Wegmann,et al. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[41] E. Unanue,et al. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. , 1996, Journal of immunology.
[42] C. Janeway,et al. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells , 1996, The Journal of experimental medicine.
[43] P. van Endert,et al. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes , 1995, The Journal of experimental medicine.
[44] D. Wegmann,et al. Epitope specificity, cytokine production profile and diabetogenic activity of insulin‐specific T cell clones isolated from NOD mice , 1995, European journal of immunology.
[45] M. A. Bowman,et al. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. , 1994, The Journal of clinical investigation.
[46] E. Bonifacio,et al. Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity , 1994, Diabetes.
[47] T. Utsugi,et al. Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice. , 1994, Journal of immunology.
[48] B. Bergman,et al. Islet-Specific T-Cell Clones From the NOD Mouse Respond to β-Granule Antigen , 1994, Diabetes.
[49] S. Baekkeskov,et al. Differential Expression of GAD65 and GAD67 in Human, Rat, and Mouse Pancreatic Islets , 1993, Diabetes.
[50] A. Tobin,et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes , 1993, Nature.
[51] R. Tisch,et al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice , 1993, Nature.
[52] C. Benoist,et al. Following a diabetogenic T cell from genesis through pathogenesis , 1993, Cell.
[53] O. Madsen,et al. Differential Expression of Glutamic Acid Decarboxylase in Rat and Human Islets , 1993, Diabetes.
[54] H. Weiner,et al. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. , 1991 .
[55] S. Baekkeskov,et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase , 1990, Nature.
[56] J. Palmer,et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. , 1983, Science.
[57] S. Baekkeskov,et al. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins , 1982, Nature.
[58] F. Wong,et al. GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice. , 1998, The Journal of clinical investigation.
[59] J. Petersen,et al. Treatment with GAD65 or BSA does not protect against diabetes in BB rats. , 1997, Autoimmunity.
[60] P. Bougnères,et al. Treatment of prediabetic patients with insulin: experience and future. European Prediabetes Study Group. , 1996, Hormone research.
[61] H. Rammensee,et al. Peptides naturally presented by MHC class I molecules. , 1993, Annual review of immunology.