Electrophysiological analysis of context effects in Alzheimer's disease.

Event-related potentials elicited by semantically associated and unassociated word pairs embedded in congruous and semantically anomalous spoken sentences were recorded from patients with Alzheimer's disease (AD) and healthy older and young controls as a means of examining the nature, time course, and relation between word and sentence context effects. All groups demonstrated lexical priming in nonsensical sentences, but it was earlier in the young (200-600 ms) than in the older controls (600-800 ms), and even later in the probable AD patients (800-1,000 ms). Moreover, processing in both the elderly and AD groups benefited disproportionately from a meaningful sentence context. The results do not accord well with either a strictly structural or a strictly functional account of the semantic impairments in AD.

[1]  B. Reed,et al.  Assessment of associative relations in alzheimer's disease: Evidence for preservation of semantic memory , 1995 .

[2]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[3]  J. Hodges,et al.  Naming and Knowing in Dementia of Alzheimer's Type , 1996, Brain and Language.

[4]  W. Nelson Francis,et al.  FREQUENCY ANALYSIS OF ENGLISH USAGE: LEXICON AND GRAMMAR , 1983 .

[5]  D. Friedman,et al.  Event-Related Potential and Behavioral Correlates of Semantic Processing in Alzheimer′s Patients and Normal Controls , 1995, Brain and Language.

[6]  J. Fermaglich.  Electric Fields of the Brain: The Neurophysics of EEG , 1982 .

[7]  Arlene J. Astell,et al.  Tip-of-the-Tongue States and Lexical Access in Dementia , 1996, Brain and Language.

[8]  W. Jagust,et al.  Automatic semantic priming with various category relations in Alzheimer's disease and normal aging. , 1991, Psychology and aging.

[9]  M. Kutas,et al.  Event-related brain potentials during initial encoding and recognition memory of congruous and incongruous words , 1986 .

[10]  D. Salmon,et al.  Semantic memory impairment in Alzheimer's disease: Failure of access or degraded knowledge? , 1992, Neuropsychologia.

[11]  R. Nebes,et al.  Preserved organization of semantic attributes in Alzheimer's disease. , 1990, Psychology and aging.

[12]  C. E. Henry,et al.  Suppression-burst activity from isolated cerebral cortex in man. , 1952, Electroencephalography and clinical neurophysiology.

[13]  Allan Collins,et al.  A spreading-activation theory of semantic processing , 1975 .

[14]  M. Yamada,et al.  [Dementia rating scale]. , 1997, Nihon rinsho. Japanese journal of clinical medicine.

[15]  H. Neville,et al.  Natural speech processing: An analysis using event-related brain potentials , 1991, Psychobiology.

[16]  Evidence for an impaired ability to determine semantic relations in Alzheimer's disease patients. , 1998, Neuropsychology.

[17]  D P Salmon,et al.  Event-related brain potentials during semantic categorization in normal aging and senile dementia of the Alzheimer's type. , 1996, Electroencephalography and clinical neurophysiology.

[18]  R. Nebes.  Semantic memory in Alzheimer's disease. , 1989, Psychological bulletin.

[19]  Robert D. Nebes,et al.  Sentence Context Influences the Interpretation of Word Meaning by Alzheimer Patients , 1996, Brain and Language.

[20]  D. Salmon,et al.  The nature of the naming deficit in Alzheimer's and Huntington's disease. , 1991, Brain : a journal of neurology.

[21]  M. Farah,et al.  A computational model of naming in Alzheimer's disease: Unitary or multiple impairments? , 1994 .

[22]  Tudor S. G. Jones,et al.  Theories of Memory , 1925 .

[23]  Juha O. Rinne,et al.  Semantic Processing of Spoken Words in Alzheimer's Disease: An Electrophysiological Study , 1998, Journal of Cognitive Neuroscience.

[24]  P. Holcomb.  Automatic and attentional processing: An event-related brain potential analysis of semantic priming , 1988, Brain and Language.

[25]  M. Bobes,et al.  ERP assessment of semantic memory in Alzheimer's disease. , 1997, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[26]  B. Ober,et al.  Lexical decision and priming in Alzheimer's disease , 1988, Neuropsychologia.

[27]  E. Tulving.  Elements of episodic memory , 1983 .

[28]  Robert D. Nebes,et al.  The Effect of Contextual Constraint on Semantic Judgments by Alzheimer Patients , 1991, Cortex.

[29]  Alex Martin,et al.  Word production and comprehension in Alzheimer's diseáse: The breakdown of semantic knowledge , 1983, Brain and Language.

[30]  J. Myerson,et al.  General slowing of lexical and nonlexical information processing in dementia of the Alzheimer type. , 1998, Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition.

[31]  John Boddy,et al.  Evoked potentials and the dynamics of language processing , 1981, Biological Psychology.

[32]  C. C. Wood,et al.  Interpretation of evoked potentials: a neurophysiological perspective. , 1981, Canadian journal of psychology.

[33]  M. Bobes,et al.  Cognitive brain activity in Alzheimer's disease: Electrophysiological response during picture semantic categorization , 1998, Journal of the International Neuropsychological Society.

[34]  B. Ober,et al.  Well-organized conceptual domains in Alzheimer's disease , 1999, Journal of the International Neuropsychological Society.

[35]  B. Ober,et al.  Semantic priming in Alzheimer's disease: Meta-analysis and theoretical evaluation , 1995 .

[36]  C. Petten.  A comparison of lexical and sentence-level context effects in event-related potentials , 1993 .

[37]  M. Kutas,et al.  Reading senseless sentences: brain potentials reflect semantic incongruity. , 1980, Science.

[38]  Morton Ann Gernsbacher,et al.  Inhibitory Control during Sentence Comprehension in Individuals with Dementia of the Alzheimer Type , 1997, Brain and Language.

[39]  Jordan Grafman,et al.  Handbook of Neuropsychology , 1991 .

[40]  R. Nebes,et al.  Instantiation of semantic categories in sentence comprehension by Alzheimer patients , 1999, Journal of the International Neuropsychological Society.

[41]  T. Bashore,et al.  Age differences in word and language processing , 1995 .

[42]  M. Kutas,et al.  Brain potentials during reading reflect word expectancy and semantic association , 1984, Nature.

[43]  Marta Kutas,et al.  Working Memory Capacity Dissociates Lexical and Sentential Context Effects , 1997 .

[44]  Mark S. Seidenberg,et al.  Double Dissociation of Semantic Categories in Alzheimer's Disease , 1997, Brain and Language.

[45]  D. Salmon,et al.  Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer's disease: Implications for the integrity of semantic memory , 1999, Journal of the International Neuropsychological Society.

[46]  N Butters,et al.  Episodic and semantic memory: a comparison of amnesic and demented patients. , 1987, Journal of clinical and experimental neuropsychology.

[47]  J A Yesavage,et al.  N400 evidence of abnormal responses to speech in Alzheimer's disease. , 1996, Electroencephalography and clinical neurophysiology.

[48]  Suzanne Corkin,et al.  Semantic impairment and anomia in Alzheimer's disease , 1986, Brain and Language.

[49]  R. Nebes,et al.  Sparing of semantic memory in Alzheimer's disease. , 1984, Journal of abnormal psychology.

[50]  J. Yesavage,et al.  Event-related brain potential evidence of spared knowledge in Alzheimer's disease. , 2001, Psychology and aging.

[51]  R. Nebes,et al.  Use of semantic context by patients with Alzheimer's disease. , 1986, Psychology and aging.

[52]  Mark S. Seidenberg,et al.  Priming and semantic memory loss in Alzheimer's disease , 1989, Brain and Language.

[53]  M. D’Esposito,et al.  Language comprehension profiles in Alzheimer's disease, multi-infarct dementia, and frontotemporal degeneration , 1996, Neurology.

[54]  Colin M. Brown,et al.  Semantic Integration in Sentences and Discourse: Evidence from the N400 , 1999, Journal of Cognitive Neuroscience.

[55]  R. Nebes,et al.  Automatic and attentional mechanisms of semantic priming in Alzheimer's disease. , 1989, Journal of Clinical and Experimental Neuropsychology.

[56]  D. Salmon,et al.  Dimensionality and clustering in the semantic network of patients with Alzheimer's disease. , 1993, Psychology and aging.

[57]  Marta Kutas,et al.  Electrophysiological insights into the nature of the semantic deficit in Alzheimer's disease , 1996, Neuropsychologia.

[58]  D. S. Pate,et al.  Lexical Priming by Pictures and Words in Normal Aging and in Dementia of the Alzheimer's Type , 1996, Brain and Language.

[59]  L. Barsalou.  Flexibility, Structure, and Linguistic Vagary in Concepts: Manifestations of a Compositional System of Perceptual Symbols , 2019, Theories of Memory.

[60]  N Butters,et al.  Differential impairment of semantic and episodic memory in Alzheimer's and Huntington's diseases: a controlled prospective study. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[61]  K. Yanagisawa.  [Senile dementia of Alzheimer type]. , 1999, Ryoikibetsu shokogun shirizu.

[62]  R. Keefover,et al.  Aging and cognition. , 1998, Neurologic clinics.

[63]  K. Bayles,et al.  Confrontation naming impairment in dementia , 1983, Brain and Language.

[64]  D. Bub,et al.  Semantic memory loss in dementia of Alzheimer's type. What do various measures measure? , 1990, Brain : a journal of neurology.

[65]  M. Kutas,et al.  The N400 in a semantic categorization task across 6 decades. , 1998, Electroencephalography and clinical neurophysiology.

[66]  C. C. Wood,et al.  Event-related potentials, lexical decision and semantic priming. , 1985, Electroencephalography and clinical neurophysiology.

[67]  J. Hodges,et al.  Is semantic memory consistently impaired early in the course of Alzheimer's disease? Neuroanatomical and diagnostic implications , 1995, Neuropsychologia.

[68]  E. Andersen,et al.  Naming consistency in Alzheimer's disease , 1990, Brain and Language.

[69]  E. Tulving.  Précis of Elements of episodic memory , 1984, Behavioral and Brain Sciences.

[70]  Jane S. Paulsen,et al.  An Assessment of the Semantic Network in Patients with Alzheimer's Disease , 1993, Journal of Cognitive Neuroscience.