Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy

Recent advances in the use of diffuse optical techniques for monitoring the hemodynamic, metabolic, and physiological signatures of the neoadjuvant breast cancer therapy effectiveness is critically reviewed. An extensive discussion of the state-of-the-art diffuse optical mammography is presented alongside a discussion of the current approaches to breast cancer therapies. Overall, the diffuse optics field is growing rapidly with a great deal of promise to fill an important niche in the current approaches to monitor, predict, and personalize neoadjuvant breast cancer therapies.

[1]  Chao Zhou In-vivo optical imaging and spectroscopy of cerebral hemodynamics , 2007 .

[2]  G. Maret,et al.  Multiple light scattering from disordered media. The effect of brownian motion of scatterers , 1987 .

[3]  E. Miller,et al.  Tomographic optical breast imaging guided by three-dimensional mammography. , 2003, Applied optics.

[4]  Scott D. Stevens,et al.  Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements , 2011, Biomedical optics express.

[5]  B. Pogue,et al.  Optical image reconstruction using frequency-domain data: simulations and experiments , 1996 .

[6]  R. Cubeddu,et al.  Characterization of female breast lesions from multi-wavelength time-resolved optical mammography , 2005, Physics in medicine and biology.

[7]  A. Yodh,et al.  Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat during Focal Ischemia , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  J Stout,et al.  Computer-aided what? , 1986, JEMS : a journal of emergency medical services.

[9]  B. Pogue,et al.  Evaluation of breast tumor response to neoadjuvant chemotherapy with tomographic diffuse optical spectroscopy: case studies of tumor region-of-interest changes. , 2009, Radiology.

[10]  Jeremy C. Hebden,et al.  Optical tomography of breast cancer—monitoring response to primary medical therapy , 2009, Targeted Oncology.

[11]  B. Pogue,et al.  Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast. , 2001, Radiology.

[12]  Turgut Durduran,et al.  Noninvasive measurements of tissue hemodynamics with hybrid diffuse optical methods , 2004 .

[13]  Alessandro Torricelli,et al.  Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications. , 2007, Journal of biomedical optics.

[14]  D. Delpy,et al.  Optical Imaging in Medicine , 1998, CLEO/Europe Conference on Lasers and Electro-Optics.

[15]  D. Boas,et al.  Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels , 2011, Biomedical optics express.

[16]  J. Ripoll,et al.  In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green. , 2003, Medical physics.

[17]  B. Pogue,et al.  In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography. , 2010, Medical physics.

[18]  M. Schweiger,et al.  Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography. , 2003, Optics letters.

[19]  D. Yee,et al.  Neoadjuvant chemotherapy of locally advanced breast cancer: predicting response with in vivo (1)H MR spectroscopy--a pilot study at 4 T. , 2004, Radiology.

[20]  Brian W. Pogue,et al.  Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[21]  B. Tromberg,et al.  Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[22]  P. Vaupel,et al.  Blood flow and oxygenation status of human tumors , 1999, Strahlentherapie und Onkologie.

[23]  P. Vaupel,et al.  Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. , 2001, Journal of the National Cancer Institute.

[24]  Ludovic Ferrer,et al.  Monitoring of early response to neoadjuvant chemotherapy in stage II and III breast cancer by [18F]fluorodeoxyglucose positron emission tomography. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[25]  G. Hortobagyi,et al.  Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  B. Tromberg,et al.  Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment , 2011, Proceedings of the National Academy of Sciences.

[27]  M. Eppstein,et al.  Fluorescence-enhanced optical imaging in large tissue volumes using a gain-modulated ICCD camera. , 2003, Physics in medicine and biology.

[28]  Frank Sauer,et al.  Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries. , 2007, Journal of biomedical optics.

[29]  David Hsiang,et al.  Frequent optical imaging during breast cancer neoadjuvant chemotherapy reveals dynamic tumor physiology in an individual patient. , 2010, Academic radiology.

[30]  M. Cutler TRANSILLUMINATION OF THE BREAST , 1931, Annals of surgery.

[31]  P J Drew,et al.  Evaluation of response to neoadjuvant chemoradiotherapy for locally advanced breast cancer with dynamic contrast-enhanced MRI of the breast. , 2001, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[32]  M. Schweiger,et al.  Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans. , 2007, Optics express.

[33]  Alessandro Torricelli,et al.  Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions , 2005, Physics in medicine and biology.

[34]  G Brix,et al.  MR mammography with pharmacokinetic mapping for monitoring of breast cancer treatment during neoadjuvant therapy. , 1994, Magnetic resonance imaging clinics of North America.

[35]  Stephen P Povoski,et al.  A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions , 2007, Breast Cancer Research.

[36]  D. Mankoff,et al.  [Tc-99m]-sestamibi uptake and washout in locally advanced breast cancer are correlated with tumor blood flow. , 2002, Nuclear medicine and biology.

[37]  S Yoshida,et al.  Changes in the findings of dynamic MRI by preoperative CAF chemotherapy for patients with breast cancer of stage II and III: pathologic correlation. , 1999, Oncology reports.

[38]  E. Conant,et al.  Breast Cancer Detection Based on Incremental Biochemical and Physiological Properties of Breast Cancers , 2005 .

[39]  S. Arridge,et al.  Reconstruction of optical properties of phantom and breast lesion in vivo from paraxial scanning data , 2005, Physics in medicine and biology.

[40]  B. Tromberg,et al.  In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy. , 2006, Journal of biomedical optics.

[41]  Rainer Linke,et al.  18F-FDG PET and 99mTc-sestamibi scintimammography for monitoring breast cancer response to neoadjuvant chemotherapy: a comparative study , 2001, European Journal of Nuclear Medicine.

[42]  B Chance,et al.  Near‐Infrared Images Using Continuous, Phase‐Modulated, and Pulsed Light with Quantitation of Blood and Blood Oxygenation a , 1998, Annals of the New York Academy of Sciences.

[43]  Guoqiang Yu,et al.  Portable optical tissue flow oximeter based on diffuse correlation spectroscopy. , 2009, Optics letters.

[44]  S. Arridge Photon-measurement density functions. Part I: Analytical forms. , 1995, Applied optics.

[45]  Eddy Kuwana,et al.  Fluorescence lifetime spectroscopy for pH sensing in scattering media. , 2003, Analytical chemistry.

[46]  G. Hortobagyi,et al.  Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy. , 1988, Radiology.

[47]  G. Cocconi,et al.  Problems in evaluating response of primary breast cancer to systemic therapy , 2005, Breast Cancer Research and Treatment.

[48]  Alessandro Torricelli,et al.  Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy. , 2010, Journal of biomedical optics.

[49]  R. Cubeddu,et al.  Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography. , 2004, Journal of biomedical optics.

[50]  A. Darzi,et al.  Diffuse optical imaging of the healthy and diseased breast: A systematic review , 2008, Breast Cancer Research and Treatment.

[51]  Lihong V. Wang,et al.  Tutorial on Photoacoustic Microscopy and Computed Tomography , 2008, IEEE Journal of Selected Topics in Quantum Electronics.

[52]  M. Huang,et al.  Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction. , 2005, Radiology.

[53]  Quing Zhu,et al.  Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring. , 2007, Surgical oncology clinics of North America.

[54]  B. Tromberg,et al.  Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. , 2004, Journal of biomedical optics.

[55]  J. Giammarco,et al.  Bulk optical properties of healthy female breast tissue , 2002, Physics in medicine and biology.

[56]  Ting-Yim Lee,et al.  Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements: errata , 2012, Biomedical optics express.

[57]  S R Arridge,et al.  Recent advances in diffuse optical imaging , 2005, Physics in medicine and biology.

[58]  P M Schlag,et al.  Frequency-domain techniques enhance optical mammography: initial clinical results. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Subhadra Srinivasan,et al.  Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data. , 2008, Journal of biomedical optics.

[60]  M. Schweiger,et al.  Three-dimensional time-resolved optical mammography of the uncompressed breast , 2007 .

[61]  N. Hylton,et al.  MRI in breast cancer therapy monitoring , 2011, NMR in biomedicine.

[62]  B. Pogue,et al.  Spatially variant regularization improves diffuse optical tomography. , 1999, Applied optics.

[63]  L. Mauriac,et al.  Neoadjuvant chemotherapy: are we barking up the right tree? , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.

[64]  Britton Chance,et al.  Quantitative measurement of optical parameters in normal breasts using time-resolved spectroscopy: in vivo results of 30 Japanese women. , 1996, Journal of biomedical optics.

[65]  L. Fajardo,et al.  Phase-contrast diffuse optical tomography pilot results in the breast. , 2008, Academic radiology.

[66]  Keith D. Paulsen,et al.  MRI-guided fluorescence tomography of PPIX in the breast: a case study , 2011, BiOS.

[67]  Daniel Rohrbach,et al.  Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer: a case report. , 2010, Optics express.

[68]  Subhadra Srinivasan,et al.  Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors. , 2008, Optics express.

[69]  Dirk Grosenick,et al.  A multichannel time-domain scanning fluorescence mammograph: performance assessment and first in vivo results. , 2011, The Review of scientific instruments.

[70]  Dianne Georgian-Smith,et al.  Prospective comparison of mammography, sonography, and MRI in patients undergoing neoadjuvant chemotherapy for palpable breast cancer. , 2005, AJR. American journal of roentgenology.

[71]  P. Bastiaens,et al.  Fluorescence lifetime imaging microscopy: spatial resolution of biochemical processes in the cell. , 1999, Trends in cell biology.

[72]  Sergio Fantini,et al.  Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images. , 2004, Journal of biomedical optics.

[73]  T. Durduran,et al.  Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study , 2010, Biomedical optics express.

[74]  L. Fajardo,et al.  Near-infrared optical imaging of the breast with model-based reconstruction. , 2002, Academic radiology.

[75]  Wensheng Guo,et al.  Computer aided automatic detection of malignant lesions in diffuse optical mammography. , 2010, Medical physics.

[76]  A. Yodh,et al.  Near-infrared Diffuse Correlation Spectroscopy for Assessment of Tissue Blood Flow Single Scattering @bullet Multiple Scattering Limit (dws) @bullet Correlation Diffusion Equation (dcs) Dcs System @bullet Fiber-optic Probes Cancer Therapy Monitoring @bullet Cerebral Physiology and Disease @bullet Sk , 2022 .

[77]  K. T. Moesta,et al.  Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients , 2005, Physics in medicine and biology.

[78]  R L Wahl,et al.  Metabolic monitoring of breast cancer chemohormonotherapy using positron emission tomography: initial evaluation. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[79]  A. Godavarty,et al.  Hand-held based near-infrared optical imaging devices: a review. , 2009, Medical engineering & physics.

[80]  Anna L. Brown,et al.  Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[81]  K. T. Moesta,et al.  Time-domain scanning optical mammography: II. Optical properties and tissue parameters of 87 carcinomas , 2005, Physics in medicine and biology.

[82]  T. Powles,et al.  Reduction in angiogenesis after neoadjuvant chemoendocrine therapy in patients with operable breast carcinoma , 1999, Cancer.

[83]  J. Baselga New therapeutic agents targeting the epidermal growth factor receptor. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[84]  J E Husband,et al.  Primary breast cancer: mammographic changes after neoadjuvant chemotherapy, with pathologic correlation. , 1996, Radiology.

[85]  A. Yodh,et al.  Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain. , 2006, Optics express.

[86]  J. S. Reynolds,et al.  Imaging of Spontaneous Canine Mammary Tumors Using Fluorescent Contrast Agents , 1999, Photochemistry and photobiology.

[87]  Jeremy C Hebden,et al.  Monitoring recovery after laser surgery of the breast with optical tomography: a case study. , 2005, Applied optics.

[88]  Markus Ninck,et al.  Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissue , 2010, Biomedical optics express.

[89]  Milton V. Marshall,et al.  Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study. , 2008, Radiology.

[90]  B. Tromberg,et al.  Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy , 2007, Proceedings of the National Academy of Sciences.

[91]  Campbell,et al.  Scattering and Imaging with Diffusing Temporal Field Correlations. , 1995, Physical review letters.

[92]  Soren D. Konecky,et al.  Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography. , 2009, Journal of biomedical optics.

[93]  V. Ntziachristos,et al.  Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[94]  M. Yaffe,et al.  Functional Imaging Using Diffuse Optical Spectroscopy of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer , 2010, Clinical Cancer Research.

[95]  E. D. de Vries,et al.  Toward molecular imaging-driven drug development in oncology. , 2011, Cancer discovery.

[96]  David Hsiang,et al.  Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study. , 2009, Journal of biomedical optics.

[97]  G. Dai,et al.  Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring , 2010, Biomedical optics express.

[98]  David A Mankoff,et al.  FDG PET, PET/CT, and breast cancer imaging. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[99]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[100]  D. Boas,et al.  Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation , 1997 .

[101]  V. Goh,et al.  Imaging breast cancer response during neoadjuvant systemic therapy , 2005, Expert review of anticancer therapy.

[102]  M J Holboke,et al.  Three-dimensional diffuse optical mammography with ultrasound localization in a human subject. , 2000, Journal of biomedical optics.

[103]  Douglas J. Durian,et al.  Investigating non-Gaussian scattering processes by using nth-order intensity correlation functions , 1999 .

[104]  B. Pogue,et al.  Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. , 2007, Optics letters.

[105]  R. Mesquita,et al.  Diffuse optics: Fundamentals and tissue applications , 2011 .

[106]  X. Intes Time-Domain Optical Mammography SoftScan , 2005 .

[107]  Venkataramanan Krishnaswamy,et al.  Radiologic and near-infrared/optical spectroscopic imaging: where is the synergy? , 2010, AJR. American journal of roentgenology.

[108]  Christos Hatzis,et al.  Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[109]  Jennifer J. Gibson,et al.  Electromagnetic breast imaging: results of a pilot study in women with abnormal mammograms. , 2007, Radiology.

[110]  P. Vaupel,et al.  Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance. , 2000, International journal of oncology.

[111]  A. Yodh,et al.  In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies. , 2001, Physics in medicine and biology.

[112]  D. Weitz,et al.  Diffusing wave spectroscopy. , 1988, Physical review letters.

[113]  V Ntziachristos,et al.  Imager that combines near-infrared diffusive light and ultrasound. , 1999, Optics letters.

[114]  Preoperative chemotherapy for breast cancer: lessons learned and future prospects. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[115]  Quing Zhu,et al.  Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization. , 2008, Neoplasia.

[116]  P M Schlag,et al.  Development of a time-domain optical mammograph and first in vivo applications. , 1999, Applied optics.

[117]  David A Boas,et al.  Assessing the future of diffuse optical imaging technologies for breast cancer management. , 2008, Medical physics.

[118]  D. Berry,et al.  I‐SPY 2: An Adaptive Breast Cancer Trial Design in the Setting of Neoadjuvant Chemotherapy , 2009, Clinical pharmacology and therapeutics.

[119]  M. Schweiger,et al.  Diffuse optical tomography with spectral constraints and wavelength optimization. , 2005, Applied optics.

[120]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[121]  John C Rasmussen,et al.  Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine. , 2008, Journal of biomedical optics.

[122]  Lothar Lilge,et al.  Association between Transillumination Breast Spectroscopy and Quantitative Mammographic Features of the Breast , 2008, Cancer Epidemiology Biomarkers & Prevention.

[123]  B. Tromberg,et al.  Diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant , 2005 .

[124]  Robia G. Pautler,et al.  Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo. , 2010, Nano letters.

[125]  Arjun G. Yodh,et al.  Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy , 2009, PloS one.

[126]  Robert F. Bonner,et al.  Principles of Laser-Doppler Flowmetry , 1990 .

[127]  Lihong V. Wang,et al.  Biomedical Optics: Principles and Imaging , 2007 .

[128]  W. Mali,et al.  Diffuse Optical Tomography of the Breast: Initial Validation in Benign Cysts , 2008, Molecular Imaging and Biology.

[129]  D. Boas,et al.  Laser speckle contrast imaging in biomedical optics. , 2010, Journal of biomedical optics.

[130]  Bruce J Tromberg,et al.  Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study. , 2005, Journal of biomedical optics.

[131]  Aaas News,et al.  Book Reviews , 1893, Buffalo Medical and Surgical Journal.

[132]  Dirk Grosenick,et al.  Late-fluorescence mammography assesses tumor capillary permeability and differentiates malignant from benign lesions. , 2009, Optics express.

[133]  M. Huang,et al.  Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases. , 2003, Neoplasia.

[134]  Paola Taroni,et al.  Diffuse optical spectroscopy of breast tissue extended to 1100 nm. , 2009, Journal of biomedical optics.

[135]  Eric L. Miller,et al.  Combined optical imaging and mammography of the healthy breast: Optical contrast derived from breast structure and compression , 2009, IEEE Transactions on Medical Imaging.

[136]  M. Huang,et al.  Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers. , 2005, Neoplasia.

[137]  S. Fantini,et al.  Near-infrared spectral imaging of the female breast for quantitative oximetry in optical mammography. , 2009, Applied optics.

[138]  Qizhi Zhang,et al.  Automated breast cancer classification using near-infrared optical tomographic images. , 2008, Journal of biomedical optics.

[139]  E. Conant,et al.  Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study. , 2005, Academic radiology.

[140]  G Gulsen,et al.  In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy , 2008, Physics in medicine and biology.

[141]  B. Pogue,et al.  A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the , 2001 .

[142]  J. Hebden,et al.  Diagnostic imaging with light. , 1997, The British journal of radiology.

[143]  Dirk Grosenick,et al.  Breast cancer: early- and late-fluorescence near-infrared imaging with indocyanine green--a preliminary study. , 2011, Radiology.

[144]  David A. Boas,et al.  "Handbook of biomedical optics", edited by David A. Boas, Constantinos Pitris, and Nimmi Ramanujam , 2012, BioMedical Engineering OnLine.

[145]  S R Arridge,et al.  Optical imaging in medicine: I. Experimental techniques , 1997, Physics in medicine and biology.

[146]  L. Esserman,et al.  Utility of magnetic resonance imaging in the management of breast cancer: evidence for improved preoperative staging. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[147]  J. Briers,et al.  Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. , 2001, Physiological measurement.

[148]  Britton Chance,et al.  Breast imaging technology: Probing physiology and molecular function using optical imaging - applications to breast cancer , 2000, Breast Cancer Research.

[149]  Robert B Livingston,et al.  Residual tumor uptake of [99mTc]‐sestamibi after neoadjuvant chemotherapy for locally advanced breast carcinoma predicts survival , 2005, Cancer.

[150]  G. Schwartz,et al.  Induction chemotherapy followed by breast conservation for locally advanced carcinoma of the breast , 1994, Cancer.

[151]  Scott C Davis,et al.  Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications. , 2010, Journal of photochemistry and photobiology. B, Biology.

[152]  B. Tromberg,et al.  Imaging in breast cancer: Diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy , 2005, Breast Cancer Research.

[153]  Jun Li,et al.  Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy. , 2005, Journal of biomedical optics.

[154]  S. Arridge,et al.  Optical imaging in medicine: II. Modelling and reconstruction , 1997, Physics in medicine and biology.

[155]  Lothar Lilge,et al.  Classification of breast tissue density by optical transillumination spectroscopy: optical and physiological effects governing predictive value. , 2004 .

[156]  S. Arridge,et al.  Optical tomography: forward and inverse problems , 2009, 0907.2586.

[157]  Hein Putter,et al.  Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients , 2011, Breast Cancer Research and Treatment.

[158]  Stephen,et al.  Temporal fluctuations in wave propagation in random media. , 1988, Physical review. B, Condensed matter.

[159]  B. Tromberg,et al.  Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. , 2007, Journal of biomedical optics.

[160]  Brian W Pogue,et al.  Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer? , 2011, Radiology.

[161]  E. Miller,et al.  Combined optical and X-ray tomosynthesis breast imaging. , 2011, Radiology.

[162]  Joann G. Elmore,et al.  Screening for breast cancer. , 1995, JAMA.

[163]  W. Marsden I and J , 2012 .

[164]  V. Ntziachristos,et al.  MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. , 2002, Neoplasia.

[165]  R. Jong,et al.  Assessing breast tissue density by transillumination breast spectroscopy (TIBS): an intermediate indicator of cancer risk. , 2007, The British journal of radiology.

[166]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[167]  S. Paik,et al.  Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[168]  Arjun G. Yodh,et al.  Non-invasive assessment of tumor neovasculature: techniques and clinical applications , 2008, Cancer and Metastasis Reviews.

[169]  X. Intes Time-domain optical mammography SoftScan: initial results. , 2005, Academic radiology.

[170]  David R. Busch,et al.  Computer-Aided, Multi-Modal, and Compression Diffuse Optical Studies of Breast Tissue , 2011 .

[171]  Brian W Pogue,et al.  In vivo near-infrared spectral detection of pressure-induced changes in breast tissue. , 2003, Optics letters.

[172]  B. Pogue,et al.  Near-Infrared Characterization of Breast Tumors In Vivo using Spectrally-Constrained Reconstruction , 2005, Technology in cancer research & treatment.

[173]  Sanjiv S Gambhir,et al.  FDG-PET and beyond: molecular breast cancer imaging. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[174]  C. V. D. van de Velde,et al.  Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[175]  L. Esserman,et al.  MRI measurements of breast tumor volume predict response to neoadjuvant chemotherapy and recurrence-free survival. , 2005, AJR. American journal of roentgenology.

[176]  Albert Cerussi,et al.  Noninvasive functional optical spectroscopy of human breast tissue , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[177]  Arjun G. Yodh,et al.  Diffuse optical measurement of blood flow in breast tumors , 2005 .

[178]  B. Tromberg,et al.  Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods. , 2000, Applied optics.

[179]  A. Yodh,et al.  Diffuse optics for tissue monitoring and tomography , 2010, Reports on progress in physics. Physical Society.

[180]  R. Gillies,et al.  Applications of magnetic resonance in model systems: cancer therapeutics. , 2000, Neoplasia.

[181]  E. Miller,et al.  Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information , 2005, Physics in medicine and biology.

[182]  Soren D. Konecky,et al.  Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI. , 2005, Medical physics.