Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.

We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.

[1]  R. Kobayashi,et al.  Interaction of the Nuclear Matrix-associated Region (MAR)-Binding Proteins, SATB1 and CDP/Cux, with a MAR Element (L2a) in an Upstream Regulatory Region of the Mouse CD8a Gene* , 1997, The Journal of Biological Chemistry.

[2]  R. Saint,et al.  Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins , 1996, Molecular and cellular biology.

[3]  R. Scheuermann,et al.  The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family. , 1995, Genes & development.

[4]  R. Scheuermann,et al.  Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-muNR enhancer repressor. Implications for regulation of immunoglobulin heavy chain expression. , 1995, The Journal of biological chemistry.

[5]  W. Sellers,et al.  Interaction between the retinoblastoma protein and the oncoprotein MDM2 , 1995, Nature.

[6]  T. Takeuchi,et al.  Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. , 1995, Genes & development.

[7]  C. Croce,et al.  Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer. , 1995, Cancer research.

[8]  S. Jane,et al.  The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein. , 1994, Blood.

[9]  Jingshi Wu,et al.  The murine Xe169 gene escapes X–inactivation like its human homologue , 1994, Nature Genetics.

[10]  W. Lee,et al.  The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[11]  P. J. Welch,et al.  A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle , 1993, Cell.

[12]  K. Helin,et al.  Characterization of the retinoblastoma binding proteins RBP1 and RBP2. , 1993, Oncogene.

[13]  S. Hiebert.  Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression , 1993, Molecular and cellular biology.

[14]  David M. Livingston,et al.  Functional interactions of the retinoblastoma protein with mammalian D-type cyclins , 1993, Cell.

[15]  Jay W. Schneider,et al.  Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation , 1993, Cell.

[16]  R. Weinberg,et al.  Regulation of retinoblastoma protein functions by ectopic expression of human cyclins , 1992, Cell.

[17]  Y. Kohwi,et al.  A tissue-specific MAR SAR DNA-binding protein with unusual binding site recognition , 1992, Cell.

[18]  A. Levine,et al.  The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation , 1992, Cell.

[19]  W. Kaelin,et al.  Identification of a growth suppression domain within the retinoblastoma gene product. , 1992, Genes & development.

[20]  I. Herskowitz,et al.  Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription , 1992, Cell.

[21]  Pearl S Huang,et al.  Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product , 1991, Nature.

[22]  F. Kaye,et al.  Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product , 1991, Cell.

[23]  David M. Livingston,et al.  The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element , 1989, Cell.

[24]  R. Scheuermann,et al.  A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer. , 1989, Genes & development.

[25]  N. Dyson,et al.  The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus , 1989, Cell.

[26]  E. Harlow,et al.  Cellular targets for transformation by the adenovirus E1A proteins , 1989, Cell.

[27]  P. L. Chen,et al.  Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. , 1988, Science.

[28]  Wen-Hwa Lee,et al.  The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity , 1987, Nature.

[29]  E. Young,et al.  The identification and characterization of ADR6, a gene required for sporulation and for expression of the alcohol dehydrogenase II isozyme from Saccharomyces cerevisiae. , 1987, Genetics.