Iterative reconstruction method for photoacoustic section imaging with integrating cylindrical detectors

Photoacoustic imaging of cross-sectional slices of extended objects requires ultrasound detectors equipped with an acoustic cylindrical lens rotating around the imaged object. The finite width of the sensor and the small focal depth of lenses with large aperture lead to various imaging artifacts. In this study, these artifacts are on the one hand avoided by the special design of the sensor and on the other hand by a model based, iterative reconstruction algorithm. The integrating property of the cylindrical detector, which exceeds in direction of the cylinder axis the size of the imaged object, avoids the lateral blurring that normally would result from the finite width of a small detector. In addition, an iterative algorithm is presented based on the system matrix that models the signal generation of the device. With this algorithm the imperfect focusing properties of the lens, especially for parts of the object moving out of focus during the rotational scan, are corrected. A direct reconstruction from the measured signals, which in case of the integrating sensor uses the inverse Radon transform, is compared to the reconstruction after iterations, both in a simulation and an experiment. A significant improvement of resolution perpendicular to the section is observed.

[1]  Markus Haltmeier,et al.  On regularization methods of EM-Kaczmarz type , 2008, 0810.3619.

[2]  William H. Richardson,et al.  Bayesian-Based Iterative Method of Image Restoration , 1972 .

[3]  Markus Haltmeier,et al.  Spatial resolution in photoacoustic tomography: effects of detector size and detector bandwidth , 2010 .

[4]  Markus Haltmeier,et al.  Experimental evaluation of reconstruction algorithms for limited view photoacoustic tomography with line detectors , 2007 .

[5]  Otmar Scherzer,et al.  Thermoacoustic computed tomography with large planar receivers , 2004 .

[6]  Robert A Kruger,et al.  Photoacoustic angiography of the breast. , 2010, Medical physics.

[7]  Lihong V. Wang,et al.  Improved in vivo photoacoustic microscopy based on a virtual-detector concept. , 2006, Optics letters.

[8]  Minghua Xu,et al.  Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[9]  Lihong V. Wang,et al.  Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo. , 2012, Journal of biomedical optics.

[10]  Robert Nuster,et al.  Photoacoustic section imaging with an integrating cylindrical detector , 2011, Biomedical optics express.

[11]  R. Nuster,et al.  Deconvolution algorithms for photoacoustic tomography to reduce blurring caused by finite sized detectors , 2013, Photonics West - Biomedical Optics.

[12]  L. Lucy An iterative technique for the rectification of observed distributions , 1974 .

[13]  P. Burgholzer,et al.  Thermoacoustic tomography with integrating area and line detectors , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[14]  Vasilis Ntziachristos,et al.  Model-based optoacoustic inversion with arbitrary-shape detectors. , 2011, Medical physics.

[15]  Quing Zhu,et al.  Three-dimensional photoacoustic tomography based on the focal-line concept. , 2011, Journal of biomedical optics.

[16]  V. Ntziachristos,et al.  Video rate optoacoustic tomography of mouse kidney perfusion. , 2010, Optics letters.

[17]  S. Jacques,et al.  Iterative reconstruction algorithm for optoacoustic imaging. , 2002, The Journal of the Acoustical Society of America.

[18]  Pinhas Ephrat,et al.  Three-dimensional photoacoustic imaging by sparse-array detection and iterative image reconstruction. , 2008, Journal of biomedical optics.