Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

[1]  Sara G. Murray,et al.  Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation , 2015, Nature Communications.

[2]  H. Wiendl,et al.  Human CD4+HLA‐G+ regulatory T cells are potent suppressors of graft‐versus‐host disease in vivo , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  H. Wiendl,et al.  Effects of glatiramer acetate in a spontaneous model of autoimmune neuroinflammation. , 2014, The American journal of pathology.

[4]  H. Wiendl,et al.  Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity , 2014, Annals of neurology.

[5]  C. Gahmberg,et al.  Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin , 2013, Thrombosis and Haemostasis.

[6]  H. Wiendl,et al.  CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation , 2013, PloS one.

[7]  H. Pape,et al.  Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS , 2013, Nature Medicine.

[8]  B. Reizis,et al.  The role of dendritic cells in autoimmunity , 2013, Nature Reviews Immunology.

[9]  A. Sirén,et al.  Ischemic stroke and traumatic brain injury: The role of the kallikrein–kinin system , 2013, Progress in Neurobiology.

[10]  E. Shevach,et al.  Absent C3a and C5a receptor signaling into CD4+ T cells enables auto-inductive TGF-β1 signaling and induction of Foxp3+ T regulatory cells , 2012, Nature Immunology.

[11]  J. Schmitt,et al.  Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. , 2012, Blood.

[12]  C. Kleinschnitz,et al.  Next-generation antithrombotics in ischemic stroke: preclinical perspective on ‘bleeding-free antithrombosis' , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  T. Renné,et al.  Regulatory mechanisms of the plasma contact system. , 2012, Thrombosis research.

[14]  John D Lambris,et al.  Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis , 2012, Circulation research.

[15]  T. Deerinck,et al.  Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation , 2012, Nature Communications.

[16]  H. Weiner,et al.  In Vivo Induction of Tr1 Cells via Mucosal Dendritic Cells and AHR Signaling , 2011, PloS one.

[17]  S. Zamvil,et al.  Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet , 2011, Journal of Neuroinflammation.

[18]  H. Wiendl,et al.  Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking. , 2011, Journal of autoimmunity.

[19]  Jeffrey A. Cohen,et al.  Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria , 2011, Annals of neurology.

[20]  T. Renné,et al.  In vivo roles of factor XII. , 2010, Blood.

[21]  S. Bicciato,et al.  Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation , 2010, Nature Medicine.

[22]  Giuseppe Cirino,et al.  Thrombin receptors and their antagonists: an update on the patent literature , 2010, Expert opinion on therapeutic patents.

[23]  G. Stoll,et al.  Factor XIIa Inhibitor Recombinant Human Albumin Infestin-4 Abolishes Occlusive Arterial Thrombus Formation Without Affecting Bleeding , 2010, Circulation.

[24]  B. Segal Th17 cells in autoimmune demyelinating disease , 2010, Seminars in Immunopathology.

[25]  A. Schmaier,et al.  Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis. , 2009, Blood.

[26]  M. Mori,et al.  Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system , 2009, Nature Medicine.

[27]  Stefan H E Kaufmann,et al.  Th17 cells. , 2009, Microbes and infection.

[28]  Thomas Korn,et al.  IL-17 and Th17 Cells. , 2009, Annual review of immunology.

[29]  A. Kelly,et al.  Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. , 2008, Blood.

[30]  A. Schmaier The elusive physiologic role of Factor XII. , 2008, The Journal of clinical investigation.

[31]  L. Steinman A rush to judgment on Th17 , 2008, The Journal of experimental medicine.

[32]  Lieping Chen,et al.  B7‐H1 restricts neuroantigen‐specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis , 2008, European journal of immunology.

[33]  Sergio E. Baranzini,et al.  Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets , 2008, Nature.

[34]  A. Schmaier Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system. , 2008, International immunopharmacology.

[35]  I. Tsigelny,et al.  Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. , 2007, Current medicinal chemistry.

[36]  H. Lassmann,et al.  The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease , 2007, The Journal of experimental medicine.

[37]  James G. Krueger,et al.  Pathogenesis and therapy of psoriasis , 2007, Nature.

[38]  Lawrence Steinman,et al.  A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage , 2007, Nature Medicine.

[39]  G. Krishnamoorthy,et al.  Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. , 2006, The Journal of clinical investigation.

[40]  T. Renné,et al.  Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis , 2006, The Journal of experimental medicine.

[41]  Charles R G Guttmann,et al.  Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability. , 2005, Archives of neurology.

[42]  H. Lassmann,et al.  Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[43]  M. Gyetko,et al.  Urokinase-Deficient Mice Fail To Generate a Type 2 Immune Response following Schistosomal Antigen Challenge , 2004, Infection and Immunity.

[44]  U. Grohmann,et al.  Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation 1 , 2003, The Journal of Immunology.

[45]  M. Cuzner,et al.  Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. , 2003, Brain : a journal of neurology.

[46]  G. Bouma,et al.  The immunological and genetic basis of inflammatory bowel disease , 2003, Nature Reviews Immunology.

[47]  R. Colman,et al.  Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR) , 2003, Inflammation Research.

[48]  Jorge R. Oksenberg,et al.  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis , 2002, Nature Medicine.

[49]  J. Antel,et al.  Kinin B1 Receptor Expression and Function on Human Brain Endothelial Cells , 2000, Journal of neuropathology and experimental neurology.

[50]  S. Rosenberg,et al.  Identification of a Urokinase Receptor-Integrin Interaction Site , 2000, The Journal of Biological Chemistry.

[51]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[52]  L. Weiner,et al.  Improvements in obtaining and characterizing mouse cerebrospinal fluid☆ , 1983, Journal of Neuroimmunology.

[53]  T. Reunala,et al.  Inflammatory cells, IgA, C3, fibrin and fibronectin in skin lesions in dermatitis herpetiformis , 1981, The British journal of dermatology.

[54]  C. Piccinato,et al.  The role of the kallikrein‐kinin system, matrix metalloproteinases, and tissue inhibitors of metalloproteinases in the early restenosis of covered stents in the femoropopliteal arterial segment , 2017, Journal of vascular surgery.

[55]  L. Steinman,et al.  Innate and Adaptive Autoimmunity Directed to the Central Nervous System , 2009, Neuron.

[56]  Jia Newcombe,et al.  Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. , 2008, The American journal of pathology.

[57]  K. Walsh,et al.  Word Count , 2005 .