Intrapartum cardiotocography trace pattern pre-processing, features extraction and fetal health condition diagnoses based on RCOG guideline

Context The computerization of both fetal heart rate (FHR) and intelligent classification modeling of the cardiotocograph (CTG) is one of the approaches that are utilized in assisting obstetricians in conducting initial interpretation based on (CTG) analysis. CTG tracing interpretation is crucial for the monitoring of the fetal status during weeks into the pregnancy and childbirth. Most contemporary studies rely on computer-assisted fetal heart rate (FHR) feature extraction and CTG categorization to determine the best precise diagnosis for tracking fetal health during pregnancy. Furthermore, through the utilization of a computer-assisted fetal monitoring system, the FHR patterns can be precisely detected and categorized. Objective The goal of this project is to create a reliable feature extraction algorithm for the FHR as well as a systematic and viable classifier for the CTG through the utilization of the MATLAB platform, all the while adhering to the recognized Royal College of Obstetricians and Gynecologists (RCOG) recommendations. Method The compiled CTG data from spiky artifacts were cleaned by a specifically created application and compensated for missing data using the guidelines provided by RCOG and the MATLAB toolbox after the implemented data has been processed and the FHR fundamental features have been extracted, for example, the baseline, acceleration, deceleration, and baseline variability. This is followed by the classification phase based on the MATLAB environment. Next, using the guideline provided by the RCOG, the signals patterns of CTG were classified into three categories specifically as normal, abnormal (suspicious), or pathological. Furthermore, to ensure the effectiveness of the created computerized procedure and confirm the robustness of the method, the visual interpretation performed by five obstetricians is compared with the results utilizing the computerized version for the 150 CTG signals. Results The attained CTG signal categorization results revealed that there is variability, particularly a trivial dissimilarity of approximately (+/−4 and 6) beats per minute (b.p.m.). It was demonstrated that obstetricians’ observations coincide with algorithms based on deceleration type and number, except for acceleration values that differ by up to (+/−4). Discussion The results obtained based on CTG interpretation showed that the utilization of the computerized approach employed in infirmaries and home care services for pregnant women is indeed suitable. Conclusions The classification based on CTG that was used for the interpretation of the FHR attribute as discussed in this study is based on the RCOG guidelines. The system is evaluated and validated by experts based on their expert opinions and was compared with the CTG feature extraction and classification algorithms developed using MATLAB.

[1]  Luísa Castro,et al.  Systematic Review of Intrapartum Fetal Heart Rate Spectral Analysis and an Application in the Detection of Fetal Acidemia , 2021, Frontiers in Pediatrics.

[2]  Nooritawati Md. Tahir,et al.  A systematic review of automated pre-processing, feature extraction and classification of cardiotocography , 2021, PeerJ Comput. Sci..

[3]  Mesut Toğaçar,et al.  Predicting fetal hypoxia using common spatial pattern and machine learning from cardiotocography signals , 2020 .

[4]  Niels Uldbjerg,et al.  Fetal Heart Rate Variability Is Affected by Fetal Movements: A Systematic Review , 2020, Frontiers in Physiology.

[5]  A. Casini,et al.  Heart Rate Variability in the Perinatal Period: A Critical and Conceptual Review , 2020, Frontiers in Neuroscience.

[6]  George Nikolakopoulos,et al.  An exploratory approach to fetal heart rate–pH-based systems , 2020, Signal Image Video Process..

[7]  Thar Baker,et al.  Analysis of Dimensionality Reduction Techniques on Big Data , 2020, IEEE Access.

[8]  Nicolò Pini,et al.  Integrating machine learning techniques and physiology based heart rate features for antepartum fetal monitoring , 2020, Comput. Methods Programs Biomed..

[9]  Majid Akhavan-Amjadi,et al.  Fetal electrocardiogram modeling using hybrid evolutionary firefly algorithm and extreme learning machine , 2020, Multidimens. Syst. Signal Process..

[10]  B. Hayes-Gill,et al.  Relative accuracy of computerized intrapartum fetal heart rate pattern recognition by ultrasound and abdominal electrocardiogram detection , 2019, Acta obstetricia et gynecologica Scandinavica.

[11]  Wisnu Jatmiko,et al.  Ensemble learning versus deep learning for Hypoxia detection in CTG signal , 2019, 2019 International Workshop on Big Data and Information Security (IWBIS).

[12]  Umit Budak,et al.  A Simple and Effective Approach for Digitization of the CTG Signals from CTG Traces , 2019, IRBM.

[13]  Zafer Cömert,et al.  Prediction of intrapartum fetal hypoxia considering feature selection algorithms and machine learning models , 2019, Health Information Science and Systems.

[14]  Abdulaziz S. Alsayyari,et al.  Fetal cardiotocography monitoring using Legendre neural networks , 2019, Biomedizinische Technik. Biomedical engineering.

[15]  N. Satish Chandra Reddy,et al.  Classification and Feature Selection Approaches by Machine Learning Techniques: Heart Disease Prediction , 2019, International Journal of Innovative Computing.

[16]  Simon James Fong,et al.  Automatic Cardiotocography Diagnostic System Based on Hilbert Transform and Adaptive Threshold Technique , 2019, IEEE Access.

[17]  Jacek M. Leski,et al.  Fuzzy classifier based on clustering with pairs of ε-hyperballs and its application to support fetal state assessment , 2019, Expert Syst. Appl..

[18]  Yang Zhang,et al.  Computer-Aided Diagnosis System of Fetal Hypoxia Incorporating Recurrence Plot With Convolutional Neural Network , 2019, Front. Physiol..

[19]  E. C. Erkus,et al.  Detection of abnormalities in heart rate using multiple Fourier transforms , 2019, International Journal of Environmental Science and Technology.

[20]  Simon Fong,et al.  Nonlinear characterization and complexity analysis of cardiotocographic examinations using entropy measures , 2018, The Journal of Supercomputing.

[21]  Zafer Cömert,et al.  Prognostic model based on image-based time-frequency features and genetic algorithm for fetal hypoxia assessment , 2018, Comput. Biol. Medicine.

[22]  Zafer Cömert,et al.  Fetal Hypoxia Detection Based on Deep Convolutional Neural Network with Transfer Learning Approach , 2018, CSOS.

[23]  R. Vullings,et al.  Detection rate of fetal distress using contraction-dependent fetal heart rate variability analysis , 2018, Physiological measurement.

[24]  Paul Fergus,et al.  Machine learning ensemble modelling to classify caesarean section and vaginal delivery types using Cardiotocography traces , 2018, Comput. Biol. Medicine.

[25]  J. De Jonckheere,et al.  Inter-observer reliability of 4 fetal heart rate classifications. , 2017, Journal of gynecology obstetrics and human reproduction.

[26]  Scientific Impact Paper No. 49: Ultrasound from Conception to 10+0 Weeks of Gestation , 2015 .

[27]  Hasan Ocak,et al.  A Medical Decision Support System Based on Support Vector Machines and the Genetic Algorithm for the Evaluation of Fetal Well-Being , 2013, Journal of Medical Systems.

[28]  Gábor Hosszú,et al.  Fetal phonocardiography - Past and future possibilities , 2011, Comput. Methods Programs Biomed..

[29]  Maria Antónia Costa Development and evaluation of a combination of computer analysis of cardiotocografy and electrocardiography for intrapartum fetal monitoring , 2011 .

[30]  Edmond Zahedi,et al.  Antepartum fetal heart rate feature extraction and classification using empirical mode decomposition and support vector machine , 2011, Biomedical engineering online.

[31]  Mohd Alauddin Mohd Ali,et al.  A novel cardiotocography fetal heart rate baseline estimation algorithm , 2010 .

[32]  Doina Precup,et al.  System-identification noise suppression for intra-partum cardiotocography to discriminate normal and hypoxic fetuses , 2006, 2006 Computers in Cardiology.

[33]  Chrysostomos D. Stylios,et al.  Predicting the risk of metabolic acidosis for newborns based on fetal heart rate signal classification using support vector machines , 2006, IEEE Transactions on Biomedical Engineering.

[34]  D. Devane,et al.  Midwives' visual interpretation of intrapartum cardiotocographs: intra- and inter-observer agreement. , 2005, Journal of advanced nursing.

[35]  Richard Cookson,et al.  Willingness to pay methods in health care: a sceptical view. , 2003, Health economics.

[36]  Zoltán Benyó,et al.  An advanced method in fetal phonocardiography , 2003, Comput. Methods Programs Biomed..

[37]  Amparo Alonso-Betanzos,et al.  Intelligent analysis and pattern recognition in cardiotocographic signals using a tightly coupled hybrid system , 2002, Artif. Intell..

[38]  Zbigniew R. Struzik,et al.  Cumulative Effective Hoelder Exponent Based Indicator for Real Time Fetal Heartbeat Analysis During Labour , 2002 .

[39]  M. Peters,et al.  Monitoring the fetal heart non-invasively: a review of methods , 2001, Journal of perinatal medicine.

[40]  J. Bernardes,et al.  SisPorto 2.0: A Program for Automated Analysis of Cardiotocograms , 2000 .

[41]  A. J. Zuckerwar,et al.  Development of a piezopolymer pressure sensor for a portable fetal heart rate monitor , 1993, IEEE Transactions on Biomedical Engineering.

[42]  D. G. Talbert,et al.  Wide Bandwidlt Fetal Phonography Using a Sensor Matched to the Compliance of the Mother's Abdominal Wall , 1986, IEEE Transactions on Biomedical Engineering.

[43]  Janusz Jezewski,et al.  Coping with limitations of fetal monitoring instrumentation to improve heart rhythm variability assessment , 2020 .

[44]  Francesco Amato,et al.  Evaluation of floatingline and foetal heart rate variability , 2018, Biomed. Signal Process. Control..

[45]  P. Rajesh Kumar,et al.  Characterization and classification of uterine magnetomyography signals using KNN classifier , 2018, 2018 Conference on Signal Processing And Communication Engineering Systems (SPACES).

[46]  Mika P. Tarvainen,et al.  Kubios HRV - Heart rate variability analysis software , 2014, Comput. Methods Programs Biomed..

[47]  Janusz Jezewski,et al.  Improving fetal heart rate signal interpretation by application of myriad filtering , 2013 .

[48]  João Bernardes,et al.  An overview of central fetal monitoring systems in labour , 2013, Journal of perinatal medicine.

[49]  Chrysostomos D. Stylios,et al.  CLASSIFICATION OF FETAL HEART RATE USING SCALE DEPENDENT FEATURES AND SUPPORT VECTOR MACHINES , 2005 .

[50]  M. M. Novak,et al.  Emergent Nature: Patterns, Growth and Scaling in the Sciences , 2001 .

[51]  Ferenc Kovács,et al.  A rule-based phonocardiographic method for long-term fetal heart rate monitoring , 2000, IEEE Transactions on Biomedical Engineering.

[52]  J. P. Marques de Sá,et al.  The Porto system for automated cardiotocographic signal analysis , 1991, Journal of perinatal medicine.

[53]  R. E. Tainsh,et al.  Fetal heart rate monitoring. , 1983, American journal of obstetrics and gynecology.

[54]  Xiaohan Wang,et al.  Computer Methods and Programs in Biomedicine , 2022 .