In vivo epidermal thickness measurement: ultrasound vs. confocal imaging

Background/purpose: In this study, in vivo skin imaging methods, ultrasound (US) and confocal microscopy (CM) were compared with regards to their accuracy in measuring the epidermal thickness. In addition an attempt was made to clarify the biological significance of the second echo‐rich line observed on US skin images, i.e. whether it represents the dermal–epidermal junction or the papillar–reticular dermis limit.

[1]  E. V. Cowdry,et al.  Ageing of human skin. I. Influence of dermal shrinkage on appearance of the epidermis in young and old fixed tissues , 1943 .

[2]  A. Katzberg.  The area of the dermo‐epidermal junction in human skin , 1958 .

[3]  J T Whitton,et al.  The thickness of the epidermis , 1973, The British journal of dermatology.

[4]  A. Klein-Szanto,et al.  Stereologic baseline data of normal human epidermis. , 1977, The Journal of investigative dermatology.

[5]  B. Querleux,et al.  In vivo cross-sectional ultrasonic imaging of human skin. , 1988, Dermatologica.

[6]  J. Bhawan,et al.  Histologic changes in skin associated with aging. , 1990, The Journal of dermatologic surgery and oncology.

[7]  C. Castells,et al.  Mathematical morphologic analysis of aging-related epidermal changes. , 1993, Analytical and quantitative cytology and histology.

[8]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. , 1995, The Journal of investigative dermatology.

[9]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. , 1999, The Journal of investigative dermatology.

[10]  H Ermert,et al.  Sonography of the skin at 100 MHz enables in vivo visualization of stratum corneum and viable epidermis in palmar skin and psoriatic plaques. , 1999, The Journal of investigative dermatology.

[11]  M Rajadhyaksha,et al.  Topographic variations in normal skin, as viewed by in vivo reflectance confocal microscopy. , 2001, The Journal of investigative dermatology.

[12]  P. Giacomoni.  Aging of Human Skin , 2006 .